Patents by Inventor Hersey Mallory, legal representative

Hersey Mallory, legal representative has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic animals, cell lines derived therefrom, and methods for screening for anti-amyloidogenic agents
    Patent number: 7276643
    Abstract: The methodologies of the present invention demonstrate that a critical balance between pro- and anti-amyloidogenic molecules exists that regulates amyloid formation and cell death in Alzheimer's disease and Parkinson's disease. ?-Synuclein, the non-amyloidogenic homologue of ?-synuclein, is a negative modulator of ?-synuclein and A? aggregation, having neuroprotective properties against ?-synuclein and A? neurotoxicity and that ?-synuclein and therapeutic agents derived therefrom block amyloidogenesis and neurodegeneration in vivo. The method of the present invention establishes that ?-synuclein blocks A? aggregation either by direct inhibition of A? amyloidogenesis or indirectly via either ?-synuclein or its 35 a.a. NAC region, inferring neuroprotective characteristics within the effected cells.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: October 2, 2007
    Assignee: The Regents of the University of California
    Inventors: Eliezer Masliah, Edward Rockenstein, Hersey Mallory, legal representative, Margaret Mallory, deceased