Patents by Inventor Hersh BHARGAVA

Hersh BHARGAVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMIGENETIC CALCIUM INDICATORS
    Publication number: 20230416320
    Abstract: A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
    Type: Application
    Filed: June 7, 2023
    Publication date: December 28, 2023
    Inventors: Eric R. SCHREITER, Luke D. LAVIS, Claire DEO, Hersh BHARGAVA, Ahmed ABDELFATTAH
  • Chemigenetic calcium indicators
    Patent number: 11708397
    Abstract: A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: July 25, 2023
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Eric R Schreiter, Luke D. Lavis, Claire Deo, Hersh Bhargava, Ahmed Abdelfattah
  • POPULATION-SPECIFIC PREDICTION OF PROSTATE CANCER RECURRENCE BASED ON STROMAL MORPHOLOGY FEATURES
    Publication number: 20210035694
    Abstract: Embodiments discussed herein facilitate determination of one of a probability of prostate cancer recurrence-free survival or a risk factor associated with prostate cancer based on intra-tumor stromal morphology. Example embodiments can perform operations comprising: accessing a digitized histological image of a prostate of a patient, wherein the histological image comprises a region of interest associated with prostate cancer; identifying nuclei of intra-tumoral stromal cells within the region of interest; extracting, for the region of interest of the digitized histological image, one or more features describing the structure of the intra-tumoral stromal cells; and generating, via a model based at least on the one or more features, one of a probability of prostate cancer recurrence-free survival or a risk score associated with prostate cancer for the patient based at least on the extracted one or more features.
    Type: Application
    Filed: May 29, 2020
    Publication date: February 4, 2021
    Inventors: Anant Madabhushi, Hersh Bhargava, Patrick Leo, Priti Lal
  • CHEMIGENETIC CALCIUM INDICATORS
    Publication number: 20200317743
    Abstract: A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
    Type: Application
    Filed: December 31, 2018
    Publication date: October 8, 2020
    Inventors: Eric R SCHREITER, Luke D. LAVIS, Claire DEO, Hersh BHARGAVA, Ahmed ABDELFATTAH