Abstract: Endoscopes comprising a reusable hand-piece and separable disposable shaft assembly are illustrated and described. The reusable hand-piece includes a housing having an articulation control mounted thereto and an electronics module mounted thereto. The articulation control includes control knobs and concentric drive shafts for articulation. The electronics module includes a battery, a control board, and an optical and/or electrical connector. The separable disposable shaft comprises a housing having an articulation wire actuating assembly mounted thereto and an optical and/or electrical connector mounted thereto. When the housing of the hand-piece and the housing of the separable disposable shaft assembly are joined together, the articulation control engages the articulation wire actuating assembly and the optical and/or electrical connector of the reusable hand-piece engages the optical and/or electrical connector of the disposable shaft assembly.