Patents by Inventor Hershel Herzog

Hershel Herzog has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and reagents for N-alkylating ureides
    Patent number: 6906079
    Abstract: A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I: with an alkylating agent of structure III: in the presence of a basic catalyst in an aprotic reaction medium. The ureide may be a 5,5-disubstituted barbituric acid, or it may be phenytoin, glutethimide, and ethosuximide. The alkylating agent is an ester of a sulfonic acid. The base may be a hydride or amine. A preferred process comprises N-alkoxyalkylating 5,5-diphenyl-barbituric acid with methoxymethyl methanesulfonate in the presence of di-isopropyl ethyl amine and isolating the resultant N,N?-bismethoxymethyl-5,5-diphenyl-barbituric acid. The invention also contemplates the novel compounds N-methoxymethyl-5,5-diphenylbarbituric acid, N-methoxymethyl ethosuximide, and N-methoxymethyl glutethimide, and a method comprising administering them to a patient.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: June 14, 2005
    Assignee: Taro Pharmaceutical Industries Limited
    Inventors: Daniela Gutman, Hershel Herzog
  • Method and reagents for N-alkylating ureides
    Publication number: 20040167358
    Abstract: A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I 1
    Type: Application
    Filed: October 17, 2003
    Publication date: August 26, 2004
    Inventors: Daniela Gutman, Hershel Herzog
  • N-methoxymethyl-5,5-diphenylbarbituric acid
    Patent number: 6664262
    Abstract: A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I: with an alkylating agent of structure III: in the presence of a basic catalyst in aprotic reaction medium. The ureide may be a 5,5-disubstituted barbituric acid, or it may be phenytoin, glutethimide, and ethosuximide. The alkylating agent is an ester of a sulfonic acid. The base may be a hydride or amine. A preferred process comprises N-alkoxyalkylating 5,5-diphenyl-barbituric acid with methoxymethyl methanesulfonate in the presence of di-isopropyl ethyl amine and isolating the resultant N,N′-bismethoxymethyl-5,5-diphenyl-barbituric acid. The invention also contemplates the novel compounds N-methoxymethyl-5,5-diphenylbrbituric acid, N-methoxymethyl ethosuximide, and N-methoxymethyl glutethimide, and a method comprising administering them to a patient.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: December 16, 2003
    Assignee: Taro Pharmaceuticals Industries Ltd.
    Inventors: Daniela Gutman, Hershel Herzog
  • N-methoxymethyl-5,5-diphenylbarbituric acid
    Publication number: 20030018080
    Abstract: A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I 1
    Type: Application
    Filed: February 12, 2002
    Publication date: January 23, 2003
    Applicant: Taro Pharmaceutical Industries Ltd.
    Inventors: Daniela Gutman, Hershel Herzog
  • Method and reagents for N-alkylating ureides
    Patent number: 6093820
    Abstract: A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I ##STR1## with an alkylating agent of structure III ##STR2## in the presence of a basic catalyst in an aprotic reaction medium. The ureide may be a 5,5-disubstituted barbituric acid, or it may be phenytoin, glutethimide, and ethosuximide. The alkylating agent is an ester of a sulfonic acid. The base may be a hydride or amine. A preferred process comprises N-alkoxyalkylating 5,5-diphenyl-barbituric acid with methoxymethyl methanesulfonate in the presence of di-isopropyl ethyl amine and isolating the resultant N,N'-bismethoxymethyl-5,5-diphenyl-barbituric acid. The invention also contemplates the novel compounds N-methoxymethyl-5,5-diphenylbarbituric acid, N-methoxymethyl ethosuximide, and N-methoxymethyl glutethimide, and a method comprising administering them to a patient.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: July 25, 2000
    Assignee: Taro Pharmaceutical Industries Ltd.
    Inventors: Daniela Gutman, Hershel Herzog
  • Method and reagents for N-alkylating ureides
    Patent number: RE38934
    Abstract: A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I with an alkylating agent of structure III in the presence of a basic catalyst in an aprotic reaction medium. The ureide may be a 5,5-disubstituted barbituric acid, or it may be phenytoin, glutethimide, and ethosuximide. The alkylating agent is an ester of a sulfonic acid. The base may be a hydride or amine. A preferred process comprises N-alkoxyalkylating 5,5-diphenyl-barbituric acid with methoxymethyl methanesulfonate in the presence of di-isopropyl ethyl amine and isolating the resultant N,N?-bismethoxymethyl-5,5-diphenyl-barbituric acid. The invention also contemplates the novel compounds N-methoxymethyl-5,5-diphenylbarbituric acid, N-methoxymethyl ethosuximide, and N-methoxymethyl glutethimide, and a method comprising administering them to a patient.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: January 10, 2006
    Assignee: Taro Pharmaceutical Industries Ltd.
    Inventors: Daniela Gutman, Hershel Herzog