Abstract: The present invention relates to a genetically modified plant or plant cell derived from a wild-type plant or plant cell, said wild-type plant or plant cell producing at least one serine protease comprising the motif SSRGPX1LKPDX2X3APGX4SGTSMSCPHX5PX6WSPX7AX8X9SAX10MTT (SEQ ID No. 1), wherein X1 is a peptide consisting of 7 amino acid residues, X2 is I or L, X3 is T or M, X4 is a peptide consisting of 27 or 28 amino acid residues, X5 is a peptide consisting of 12 amino acid residues, X6 is T or E, X7 is S or A, X8 is V or I, X9 is K or R and X10 is I or M, wherein the proteolytic activity of the at least one serine protease in the genetically modified plant or plant cell is reduced compared to its activity in the wild-type plant or plant cell, wherein the genetically modified plant or plant cell comprises at least one exogenous nucleic acid molecule encoding for at least one protein or polypeptide of interest.

Abstract: A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having ?1,2-xylosyltransferase activity or being complementary thereto.

Abstract: Provided is a novel method to produce a plant cell or plant having an altered N-glycosylation pattern resulting, in particular, in a low level of ?-1,2-xylose residues and core ?-1,3-fucose residues on protein-bound N-glycans. The plant cell or plant is of particular interest for producing therapeutic glycoproteins with a low, or not detectable, level of ?-1,2-xylose and ?-1,3-fucose residues. Also provided are novel ?-1,3-fucosyltransferase nucleotide sequences and uses.

Abstract: The present invention provides a method of expressing a plant Lewis-type ?1,3-galactosyltransferase in an organism comprising the step of providing the organism with a nucleic acid molecule comprising a sequence A which is defined as being selected from: a) a sequence according to SEQ ID NO: 1 with an open reading frame from base pair 1-1932, j) a sequence which is at least 50% identical with SEQ ID NO: 1, k) a sequence which hybridizes with SEQ ID NO: 1 under stringent conditions, or l) a sequence which has degenerated to SEQ ID NO: 1 due to the genetic code, wherein the sequences a) to d) encode a plant protein having Lewis-type ?1,3-galactosyltransferase activity, or m) a sequence which is complementary to one of the sequences a) to d), and expressing a protein encoded by sequence A or if the organism comprises a sequence A in its wildtype form overexpressing a protein encoded by sequence A.

Abstract: A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having ?1,2-xylosyltransferase activity or being complementary thereto.

Abstract: A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having ?1,2-xylosyltransferase activity or being complementary thereto.

Abstract: The invention relates to the production of gonadotrophins and corresponding receptors in transgenic plants. The invention provides a method to produce a gonadotrophin or its corresponding receptor in a transgenic plant with modified glycosylation machinery, in order to allow for mammalian type of glycosidic side chains of gonadotrophin and its corresponding receptor.

Abstract: A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having &bgr;1,2-xylosyltransferase activity or being complementary thereto.