Patents by Inventor Hervé Dumas

Hervé Dumas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes
    Patent number: 8247448
    Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: August 21, 2012
    Assignee: Merck Patent GmbH
    Inventors: Jean-Jacques Zeiller, Hervé Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof
    Patent number: 8063067
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: November 22, 2011
    Assignee: Merck Patent GmbH
    Inventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia, atherosclerosis and diabetes
    Patent number: 7820847
    Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: October 26, 2010
    Assignee: Merck Patent GmbH
    Inventors: Jean-Jacques Zeiller, Hervé Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes
    Publication number: 20100261789
    Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Application
    Filed: June 23, 2010
    Publication date: October 14, 2010
    Inventors: Jean-Jacques Zeiller, Hervé Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems
    Patent number: 7723358
    Abstract: The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: May 25, 2010
    Assignee: Merck Patent GmbH
    Inventors: Philippe Guedat, Francois Collonges, Olivier Chevreuil, Hervé Dumas, Marie Noelle Denault, Stéphane Yvon, Peter Kane, Julia Lainton, Avril Robertson, Bernd Wendt
  • Butanoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof
    Patent number: 7678831
    Abstract: Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the preparation of these compounds. Compounds of formula (I) are activators of PPAR? and PPAR? isoforms.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: March 16, 2010
    Assignee: Merck Patent GmbH
    Inventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Thiazolypiperidine derivatives as MTP inhibitors
    Patent number: 7674803
    Abstract: The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2?, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: March 9, 2010
    Assignee: Merck Patent GmbH
    Inventors: Philippe Guèdat, Francois Collonges, Hervé Dumas, Jean-Yves Ortholand, Jacques Decerprit, Jaxques Barbanton, Robert J. Foster, Peter Kane, Bernd Went
  • Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof
    Patent number: 7632846
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: December 15, 2009
    Assignee: Merck Patent Gesellschaft mit beschrankter
    Inventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gèrard Ferrand, Yves Bonhomme
  • HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF
    Publication number: 20090286776
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.
    Type: Application
    Filed: July 23, 2009
    Publication date: November 19, 2009
    Inventors: Jean Jacques ZEILLER, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Pentenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof
    Patent number: 7465752
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: December 16, 2008
    Assignee: Merck Patent GmbH
    Inventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Hexenoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Applications Thereof
    Publication number: 20080194564
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.
    Type: Application
    Filed: April 6, 2005
    Publication date: August 14, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Jean Jacques Zeiller, Herve Dumas, Valerie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gerard Ferrand, Yves Bonhomme
  • 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof
    Publication number: 20080194608
    Abstract: Compounds of the formula (I): in which R1, R2, R3, R?3 and R4 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, the pharmaceutical compositions comprising them, and the processes for the preparation of these compounds.
    Type: Application
    Filed: December 22, 2005
    Publication date: August 14, 2008
    Inventors: Michel Brunet, Herve Dumas, Catherine Vidal, Nathalie Adje, Benoit Van Hille, Francis Contard
  • Butanoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof
    Publication number: 20080032982
    Abstract: Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the preparation of these compounds. Compounds of formula (I) are activators of PPAR? and PPAR? isoforms.
    Type: Application
    Filed: April 6, 2005
    Publication date: February 7, 2008
    Inventors: Jean Zeiller, Herve Dumas, Valerie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gerard Ferrand, Yves Bonhomme
  • Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof
    Publication number: 20080015253
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
    Type: Application
    Filed: April 6, 2005
    Publication date: January 17, 2008
    Inventors: Jean Zeiller, Herve Dumas, Valerie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gerard Ferrand, Yves Bonhomme
  • Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems
    Publication number: 20070254919
    Abstract: The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
    Type: Application
    Filed: May 19, 2005
    Publication date: November 1, 2007
    Inventors: Philippe Guedat, Francois Collonges, Olivier Chevreuil, Herve Dumas, Marie Denault, Stephane Yvon, Peter Kane, Julia Lainton, Avril Robertson, Bernd Wendt
  • Thiazolypiperidine derivatives as mtp inhibitors
    Publication number: 20070054939
    Abstract: The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2?, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Application
    Filed: June 2, 2004
    Publication date: March 8, 2007
    Inventors: Philippe Guedat, Francois Collonges, Herve Dumas, Jean-Yves Ortholand, Jacques Decerprit, Jaxques Barbanton, Robert Foster, Peter Kane, Bernd Went
  • Butenoic acid derivatives processes for the preparation thereof pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia atherosclerosis and diabetes
    Publication number: 20060178434
    Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
    Type: Application
    Filed: July 14, 2004
    Publication date: August 10, 2006
    Inventors: Jean-Jacques Zeiller, Herve Dumas, Valerie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gerard Ferrand, Yves Bonhomme
  • N-Benzodioxolyl, n-benzodioxanyl and n-benzodioxepinyl arylcarboxamide derivatives and pharmaceutical compositions comprising them
    Publication number: 20060058372
    Abstract: The present invention relates to a compound of the formula (I): in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof in all proportions, which can be used in the treatment of dyslipidaemia, and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: October 1, 2003
    Publication date: March 16, 2006
    Inventors: Herve Dumas, Jacques Barbanton, Francois Collonges, Jacques Decerprit, Jean-Yves Ortholand, David Benzies, Stuart Cameron, Richard Foster, Stefan Guessregen, Peter Kane, Julia Lainton, Avril Robertson, Bernd Wendt, Mark Warne
  • Nitromethylthiobenzene derivatives as aldose reductase inhihibitors
    Publication number: 20030203966
    Abstract: The invention concerns novel compounds of general formula (1), their tautomeric forms, and their additive salts with pharmaceutically acceptable bases. The invention also concerns methods for preparing these compounds and their applications as medicines. These compounds inhibit the aldose reductase enzyme and can be used in the treatment or prevention of peripheral and autonomous neurological diabetic complications, renal and ocular disorders such as cataract and retinopathy.
    Type: Application
    Filed: November 12, 2002
    Publication date: October 30, 2003
    Inventors: Francois Collonges, Herve Dumas, Claude Lardy, Philippe Durbin
  • New nitromethyl ketones, process for preparing them and compositions containing them
    Publication number: 20030171422
    Abstract: The present invention relates to the compounds of formula: 1
    Type: Application
    Filed: February 12, 2003
    Publication date: September 11, 2003
    Applicant: Merck Patent GmbH
    Inventors: Claude Lardy, Jaques Barbanton, Herve Dumas, Francois Collonges, Phillppe Durbin