Patents by Inventor Hervé Le Mouellic

Hervé Le Mouellic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC GFP-AEQUORIN AS BIOLUMINESCENT CA++ REPORTERS AT THE SINGLE CELL LEVEL
    Publication number: 20100330667
    Abstract: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer (CRET).
    Type: Application
    Filed: June 4, 2010
    Publication date: December 30, 2010
    Applicants: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Valérie BAUBET, Hervé Le Mouellic, Philippe Brulet
  • Polynucleotides encoding chimeric GFP-aequorin as bioluminescent Ca++ reporters
    Patent number: 7763443
    Abstract: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer(CRET).
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: July 27, 2010
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Valérie Baubet, Hervé Le Mouellic, Philippe Brulet
  • Chimeric GFP-aequorin as bioluminescent Ca++ reporters at the single cell level
    Publication number: 20080213879
    Abstract: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer(CRET).
    Type: Application
    Filed: June 10, 2005
    Publication date: September 4, 2008
    Applicants: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Valerie Baubet, Herve Le Mouellic, Philippe Brulet
  • Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made
    Publication number: 20080182331
    Abstract: DNA gene inactivation constructs for homologous recombination in the genome of a mammalian cell are provided.
    Type: Application
    Filed: March 13, 2007
    Publication date: July 31, 2008
    Inventors: Herve Le Mouellic, Philippe Brulet
  • Chimeric GFP-aequorin as bioluminescent Ca++reporters at the single cell level
    Patent number: 6936475
    Abstract: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer (CRET).
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: August 30, 2005
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Valérie Baubet, Hervé Le Mouellic, Philippe Brulet
  • Transgenic animals
    Publication number: 20040250301
    Abstract: Animals and animal embryos comprising cells having a genome comprising a recombinant endogenous recipient gene are provided. Methods of making animals and animal embryos comprising cells having a genome comprising a recombinant endogenous recipient gene are also provided.
    Type: Application
    Filed: August 13, 2003
    Publication date: December 9, 2004
    Applicant: INSTITUT PASTEUR
    Inventors: Herve Le Mouellic, Philippe Brulet
  • Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made
    Publication number: 20040203153
    Abstract: DNA gene inactivation constructs for homologous recombination in the genome of a mammalian cell are provided.
    Type: Application
    Filed: February 4, 2004
    Publication date: October 14, 2004
    Applicant: INSTITUT PASTEUR
    Inventors: Herve Le Mouellic, Philippe Brulet
  • Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made
    Patent number: 6638768
    Abstract: The present invention relates to a process for targeted replacement of at least a part of an endogenous gene by at least a part of a foreign gene or targeted insertion of at least a part of a foreign gene at a targeted site in an endogenous gene in a cell by homologous recombination.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 28, 2003
    Assignee: Institut Pasteur
    Inventors: Hervé Le Mouellic, Philippe Brulet
  • Chimeric GFP-aequorin as bioluminescent Ca+at the single cell level
    Publication number: 20030175807
    Abstract: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer (CRET).
    Type: Application
    Filed: December 2, 2002
    Publication date: September 18, 2003
    Inventors: Valerie Baubet, Herve Le Mouellic, Philippe Brulet
  • Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made
    Patent number: 6528313
    Abstract: The present invention relates to a process for targeted replacement of at least a part of an endogenous gene by at least a part of a foreign gene or targeted insertion of at least a part of a foreign gene at a targeted site in an endogenous gene in a cell by homologous recombination.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: March 4, 2003
    Assignee: Institut Pasteur
    Inventors: Hervé Le Mouellic, Philippe Brulet
  • Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made
    Patent number: 6528314
    Abstract: A process for providing a recombinant, heterologous gene in the genome of a eukaryotic cell is provided. In particular, heterologous DNA is inserted into a recipient gene of the eukaryotic cell by homologous recombination. Moreover, a transgenic or chimeric animal comprising cells with DNA inserted into its genome by homologous recombination is disclosed. Further, the method of making these transgenic animal is taught.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 4, 2003
    Assignee: Institut Pasteur
    Inventors: Hervé Le Mouellic, Philippe Brulet