Abstract: The invention relates to a dermis equivalent comprising longitudinally at least two distinct juxtaposed dermal compartments of different compositions, along with a skin equivalent comprising this dermis equivalent.

Abstract: The present invention relates to the use of at least one compound capable of cleaving the diketone crosslinking bonds between two proteins, in a composition applied topically to the skin, as an agent for preventing or treating the signs of ageing of the skin or the orange-peel appearance. The above compound is preferably a N-hydroxy imide of formula (I). These N-hydroxy imides have inhibitory properties on the glycation of proteins and also antioxidant properties. The invention also relates to novel N-hydroxy imides included in formula (I) above.

Abstract: The invention relates to the use of at least one extract of at least one Vaccinium-type plant as the active agent in a composition or for producing a composition, in a physiologically suitable medium, said extract or said composition being intended to reduce or even inhibit the glycation of proteins, especially proteins of the skin or associated structures.

Abstract: An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen. An aged dermis equivalent, the epidermis equivalent obtained and methods of producing the aged skin and/or aged dermis equivalent and/or the epidermis equivalent.

Abstract: An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen.

Abstract: An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen. An aged dermis equivalent, the epidermis equivalent obtained and methods of producing the aged skin and/or aged dermis equivalent and/or the epidermis equivalent.

Abstract: An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen. An aged dermis equivalent, the epidermis equivalent obtained and methods of producing the aged skin and/or aged dermis equivalent and/or the epidermis equivalent.

Abstract: The hydroxystilbenes are well suited for reducing or inhibiting the glycation of certain substrates, for example the proteins of human skin and/or nails and/or hair, advantageously to preventatively and/or curatively combat glycation-related aging of the skin/nails/hair.

Abstract: The invention relates to the use of at least one extract of at least one Vaccinium-type plant as the active agent in a composition or for producing a composition, in a physiologically suitable medium, said extract or said composition being intended to reduce or even inhibit the glycation of proteins, especially proteins of the skin or associated structures.

Abstract: The hydroxystilbenes are well suited for reducing or inhibiting the glycation of certain substrates, for example the proteins of nails and/or hair, advantageously to preventatively and/or curatively combat glycation-related aging of the nails/hair.

Abstract: An aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, wherein the aged dermis equivalent comprises glycated collagen.

Abstract: The present invention includes a method for reducing or inhibiting the glycation of skin proteins, which includes topically applying a composition containing at least one selected from the group including ergothioneine, derivatives thereof, and mixtures thereof to the skin of a person in need thereof. Other embodiments of the invention include a method for making a composition for reducing the glycation of skin proteins, a method for reducing the glycation of collagen, a method for preventing or treating the signs of glycation-related ageing of the skin, a method for preventing or treating age-related loss of tonicity of the skin, a method for slimming or refining the silhouette or contours of the face, and a method for preventing or treating the orange-peel appearance of the skin.