Patents by Inventor Herve BACHELEZ

Herve BACHELEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR DETECTING HPV INFECTION IN NON-EROSIVE LICHEN PLANUS
    Publication number: 20260243765
    Abstract: The present invention relates to Lichen planus (LP), and more specifically to no erosive form of LP (NELP). The invention provides an immune signature for LP, which is not found in other cutaneomucosal chronic inflammatory diseases. The invention moreover provides different diagnosis methods and methods of treating NELP, based on this immune signature. The inventors have indeed demonstrated the presence of HPV16-specific activated CTL in blood and lesion samples corresponding to the different clinical forms of LP, not only in erosive oral LP, while a different scenario operates in other cutaneomucosal chronic inflammatory diseases. This HPV16-specific activated CTL is characterized by TCRV?3+ CD8+ T-cells oligoclonal expansions.
    Type: Application
    Filed: July 10, 2023
    Publication date: August 20, 2026
    Inventors: Marie-Lise GOUGEON, Manuelle VIGUIER, Nicolas FAZILLEAU, Herve BACHELEZ
  • Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus
    Patent number: 9547006
    Abstract: A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: January 17, 2017
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DIDEROT—PARIS 7, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Marie-Lise Gougeon, Manuelle Viguier, Herve Bachelez, Nicolas Fazilleau
  • CORRELATION OF DISEASE ACTIVITY WITH CLONAL EXPANSIONS OF HUMAN PAPILLOMAVIRUS 16-SPECIFIC CD8+ T-CELLS IN PATIENTS WITH SEVERE EROSIVE ORAL LICHEN PLANUS
    Publication number: 20150044252
    Abstract: A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
    Type: Application
    Filed: August 8, 2014
    Publication date: February 12, 2015
    Inventors: Marie-Lise GOUGEON, Manuelle VIGUIER, Herve BACHELEZ, Nicolas FAZILLEAU