Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Abstract: A two-piece valve shell (body and bolted-on top bonnet) structure reduces possible leakage paths while also providing a top-side ball/stem installation/removal path (when the bonnet piece is not present) to facilitate initial valve assembly as well as subsequent inspection/removal of the ball/stem and other valve internals for conducting valve maintenance without requiring the valve body to be removed from its process connections. Internal wetted valve surfaces are coated with tantalum to provide a tantalum ball valve suitable for use as a sulfuric acid feed valve in severe high-temperature high-pressure industrial processes such as HPAL processes. Sealing cavities created by spaced-apart body-to-bonnet and/or stem-to-bonnet sealing structures can be inertly pressurized to hermetically isolate the sealing structures from ingress/leakage of corrosive process materials.

Abstract: A method for purifying powdered silicon carbide is in the form of a starting material to form a silicon carbide having a purity of at least 99.9%. This method has the following method steps: providing a starting material having a grain size of less than 100 ?m and a silicon carbide content with at least 98% purity; and heating the starting material in a vacuum or oxygen-free atmosphere to a temperature above 1700° C. over a period of at least 8 minutes.

Abstract: A two-piece valve shell (body and bolted-on top bonnet) structure reduces possible leakage paths while also providing a top-side ball/stem installation/removal path (when the bonnet piece is not present) to facilitate initial valve assembly as well as subsequent inspection/removal of the ball/stem and other valve internals for conducting valve maintenance without requiring the valve body to be removed from its process connections. Internal wetted valve surfaces are coated with tantalum to provide a tantalum ball valve suitable for use as a sulfuric acid feed valve in severe high-temperature high-pressure industrial processes such as HPAL processes. Sealing cavities created by spaced-apart body-to-bonnet and/or stem-to-bonnet sealing structures can be inertly pressurized to hermetically isolate the sealing structures from ingress/leakage of corrosive process materials.

Abstract: A two-piece valve shell (body and bolted-on top bonnet having external fins to dissipate heat) structure reduces possible leakage paths while also providing a top-side ball/stem installation/removal path (when the bonnet piece is not present) to facilitate initial valve assembly as well as subsequent inspection/removal of the ball/stem and other valve internals for conducting valve maintenance without requiring the valve body to be removed from its process connections. In some implementations, a second/bottom bonnet is also attached to the body such that it covers another opening to the ball cavity.

Abstract: A method for purifying powdered silicon carbide is in the form of a starting material to form a silicon carbide having a purity of at least 99.9%. This method has the following method steps: providing a starting material having a grain size of less than 100 ?m and a silicon carbide content with at least 98% purity; and heating the starting material in a vacuum or oxygen-free atmosphere to a temperature above 1700° C. over a period of at least 8 minutes.

Abstract: An offset butterfly valve comprising a butterfly disc which receives a splined valve stem is disclosed. The butterfly disc is positioned for sealing an annulus formed in the valve housing when the valve stem is rotated from an open position to closed position. Provision of the spline towards the center of the valve stem and the butterfly disc allows the butterfly disc to move along the valve stem. In a particular embodiment a valve seal is secured to the butterfly disc using a securing disc which is threaded into a threaded cylinder concentric with the butterfly disc.

Abstract: An aircraft is provided, including: at least one sensor for measuring a wind; actuators (motors, control surfaces, etc.); a data base embedded aboard the aircraft, the data base associating various values of wind measurement with various set points for the attention of the actuators. The aircraft furthermore includes a system of analysis and control, arranged so as, or programmed so as: to receive values of wind measurement originating from the at least one sensor; searching, inside the data base, for a correspondence of the wind measurement values originating from the at least one sensor, and determining (as a function of this search) the directives to be dispatched to the actuators, and dispatching these determined directives to the actuators.

Abstract: A private key management system (PKMS) that may include a first agent configured to receive a request from a client device; a distributed ledger shared between the first agent and multiple second agents such that the distributed ledger operates based on a consensus algorithm; a validation engine maintained by each of the first agent and the multiple second agents, the validation engine configured to query the distributed ledger to obtain data to verify the request; and a vault module maintained by each of the first agent and the multiple second agents, the vault module configured to perform a cryptography operation based on the request after the validation engine verifies the request.

Abstract: A method of manufacturing spectacle arms includes grooving an inner face of a first cover plate to form grooves and providing a gauge with longilineal inserts. Front and rear bridges join front and rear ends of the longilineal inserts and provide front and rear indexing. The gauge is set on the inner face of the first cover plate such that the longilineal inserts are disposed in the grooves and a second cover plate is pressed and bonded on the inner face of the first plate such that the longilineal inserts are inserted between the first and second cover plates. The plates are cut around the longilineal inserts with a cutting tool after the cutting tool is positioned and held in place using corresponding front and rear tool indexing.

Abstract: An offset butterfly valve comprising a butterfly disc which receives a splined valve stem is disclosed. The butterfly disc is positioned for sealing an annulus formed in the valve housing when the valve stem is rotated from an open position to closed position. Provision of the spline towards the center of the valve stem and the butterfly disc allows the butterfly disc to move along the valve stem. In a particular embodiment a valve seal is secured to the butterfly disc using a securing disc which is threaded into a threaded cylinder concentric with the butterfly disc.

Abstract: The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion. The bag is constructed principally of fluorinated ethylene propylene (FEP) fabric, and is designed to be filled such that the cell suspension has a very thin cross-section. The bag design includes at least an inlet conduit and an outlet or inoculation conduit, which can be sterilely welded to the source of the eukaryotic cells. The use of at least two sterile-weldable conduits allows for “closed system” filling of the bags, which significantly reduces the risk of contamination relative to other cell-banking methods. The bag also include a sleeve, which can be thermo-welded to form an enclosure, which protects the inlet and outlet conduits against contamination and mechanical damage during freezing, storage and subsequent thawing.

Abstract: A method of manufacturing spectacle arms includes grooving an inner face of a first cover plate to form grooves and providing a gauge with longilineal inserts. Front and rear bridges join front and rear ends of the longilineal inserts and provide front and rear indexing. The gauge is set on the inner face of the first cover plate such that the longilineal inserts are disposed in the grooves and a second cover plate is pressed and bonded on the inner face of the first plate such that the longilineal inserts are inserted between the first and second cover plates. The plates are cut around the longilineal inserts with a cutting tool after the cutting tool is positioned and held in place using corresponding front and rear tool indexing.

Abstract: A lighter-than-air aircraft is provided including a deballasting system, the deballasting system including: at least one tank containing a liquid; a system for pressurizing the liquid of the at least one tank; and at least one sprayer arranged so as to eject the liquid from the pressurization system.

Abstract: An aircraft is provided, including: at least one sensor for measuring a wind; actuators (motors, control surfaces, etc.); a data base embedded aboard the aircraft, the data base associating various values of wind measurement with various set points for the attention of the actuators. The aircraft furthermore includes a system of analysis and control, arranged so as, or programmed so as: to receive values of wind measurement originating from the at least one sensor; searching, inside the data base, for a correspondence of the wind measurement values originating from the at least one sensor, and determining (as a function of this search) the directives to be dispatched to the actuators, and dispatching these determined directives to the actuators.

Abstract: The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion. The bag is constructed principally of fluorinated ethylene propylene (FEP) fabric, and is designed to be filled such that the cell suspension has a very thin cross-section. The bag design includes at least an inlet conduit and an outlet or inoculation conduit, which can be sterilely welded to the source of the eukaryotic cells. The use of at least two sterile-weldable conduits allows for “closed system” filling of the bags, which significantly reduces the risk of contamination relative to other cell-banking methods. The bag also include a sleeve, which can be thermo-welded to form an enclosure, which protects the inlet and outlet conduits against contamination and mechanical damage during freezing, storage and subsequent thawing.

Abstract: The disclosure provides a cell freezing and storage bag assembly and a method for using the assembly in banking eukaryotic cells for later seed train expansion. The bag is constructed principally of fluorinated ethylene propylene (FEP) fabric, and is designed to be filled such that the cell suspension has a very thin cross-section. The bag design includes at least an inlet conduit and an outlet or inoculation conduit, which can be sterilely welded to the source of the eukaryotic cells. The use of at least two sterile-weldable conduits allows for “closed system” filling of the bags, which significantly reduces the risk of contamination relative to other cell-banking methods. The bag also include a sleeve, which can be thermo-welded to form an enclosure, which protects the inlet and outlet conduits against contamination and mechanical damage during freezing, storage and subsequent thawing.