Patents by Inventor Herwig Brunner
Herwig Brunner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8013121Abstract: The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replacement.Type: GrantFiled: May 30, 2007Date of Patent: September 6, 2011Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Xin Xiong, Heike Mertsching, Steffen Rupp, Herwig Brunner
-
Publication number: 20100216239Abstract: The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replacement.Type: ApplicationFiled: May 30, 2007Publication date: August 26, 2010Applicant: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung V. Hansastrasse 26cInventors: Xin Xiong, Heike Mertsching, Steffen Rupp, Herwig Brunner
-
Publication number: 20100120145Abstract: The invention relates to a cell culture system comprising a three-dimensional, biocompatible frame structure and biocompatible nanoparticles, a method for the cultivation of cells, and the preparation of cells or cell products and tissues per se by means of such a cell culture system.Type: ApplicationFiled: April 18, 2008Publication date: May 13, 2010Applicant: Fraunhofer-Gresellschaft Zur Forderung Der Angewandten Forschung E.V.Inventors: Herwig Brunner, Heike Mertsching, Petra Kluger, Michaela Kaufmann, Achim Weber, Gunter Tovar, Kirsten Borchers
-
Publication number: 20100015704Abstract: The present invention relates to processes for obtaining melanocytes from a cell suspension, in particular from an epidermal cell suspension, by means of a culture vessel, wherein at least a part of the surface of the culture vessel facing the culture space, is modified, in particular functionalized, in particular by means of a low-pressure plasma process. Furthermore, the present invention relates to culture vessels which are modified, in particular functionalized, in particular by means of a low-pressure plasma process and are suitable for obtaining melanocytes and the use of such culture vessels for obtaining melanocytes.Type: ApplicationFiled: December 6, 2007Publication date: January 21, 2010Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDInventors: Heike Mertsching, Petra Kluger, Herwig Brunner, Christian Oehr, Vincenzo Sciarratta
-
Publication number: 20090253134Abstract: The invention concerns methods, agents and kits for qualitative and quantitative detection and identification of pathogens and pathogen spectra based on endotoxins and other pyrogens.Type: ApplicationFiled: July 5, 2007Publication date: October 8, 2009Applicant: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V.Inventors: Herwig Brunner, Doris Finkelmeier, Georg Geiger, Anke Burger-Kentischer
-
Publication number: 20080146508Abstract: The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.Type: ApplicationFiled: January 9, 2008Publication date: June 19, 2008Inventors: Afroditi KAPURNIOTU, Jurgen Bernhagen, Herwig Brunner
-
Patent number: 7368295Abstract: The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.Type: GrantFiled: August 16, 2002Date of Patent: May 6, 2008Assignee: Fraunhofer-Gesellschaft zur Foderung der Angewandten Forschung E.V.Inventors: Günter Tovar, Thomas Schiestel, Herwig Brunner, Klaus Pfizenmaier, Matthias Grell, Peter Scheurich, Angela Hammer
-
Patent number: 7342091Abstract: The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.Type: GrantFiled: December 21, 2001Date of Patent: March 11, 2008Assignee: Fraunhofer-Gesellschaf zur Forderung der angewandten Forschung e.VInventors: Afroditi Kapurniotu, Jürgen Bernhagen, Herwig Brunner
-
Publication number: 20080044830Abstract: The invention relates to functional elements that comprise, disposed on a support, microstructures containing biofunctionalized nanoparticles, methods for producing these functional elements and use of the same.Type: ApplicationFiled: December 2, 2005Publication date: February 21, 2008Applicants: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V., Universitat StuttgartInventors: Gunter Tovar, Herwig Brunner, Achim Weber, Kirsten Borchers
-
Patent number: 7303885Abstract: The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macrophage migration inhibitor factor) related diseases. In certain aspects, the present invention involves detecting MIF/Jab1 (c-Jun activation domain binding protein) interactions as a basis for modulating cellular regulatory pathways and for identifying candidate drugs for MIF-related diseases. The invention also provides methods for the identification of molecules which dissociate or prevent interaction or binding between MIF and Jab1.Type: GrantFiled: November 2, 2000Date of Patent: December 4, 2007Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Herwig Brunner, Jürgen Bernhagen, Robert Kleemann, Ralf Mischke, Afroditi Kapurniotu
-
Publication number: 20070196378Abstract: Nucleic acids that code a cell wall protein required for the hyphal development of Candida; fragments of the nucleic acids; vectors containing the nucleic acids or nucleic acid fragments; host cells containing the vectors; cell wall proteins coded by the nucleic acids; antibodies directed against the proteins; methods for producing the cell wall proteins; methods for characterizing and/or for detecting the hyphal stage of Candida; methods for detecting a Candida infection; methods for identifying substances having a therapeutic effect against diseases caused by Candida; diagnostic and pharmaceutical compositions containing the nucleic acid, nucleic acids fragments, vectors, host cells, proteins and/or antibodies directed against the cell wall protein; kits for conducting in-vitro indentation of the cell wall proteins, and; to the use of the nucleic acids, vectors, proteins or antibodies for diagnosing and treating Candida-caused diseases, i.e., producing diagnostic or pharmaceutical compositions.Type: ApplicationFiled: March 15, 2005Publication date: August 23, 2007Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Henrike Lotz, Herwig Brunner, Steffen Rupp
-
Publication number: 20070154953Abstract: The present invention relates to methods for identifying and/or detecting T-cell epitopes of a protein antigen, to methods for preparing peptide vaccines against a protein antigen, to methods for controlling the quality of receptor/ligand complexes and/or their components, to methods for preparing nanoparticles having at least one immobilized receptor unit or an immobilized receptor, to methods for preparing nanoparticles having immobilized receptor/ligand complexes, in particular peptide-presenting MHC molecules, to methods for enriching and/or isolating specific CD4+-T- or CD8+-T-lymphocytes from peripheral blood mononuclear cells, to methods for priming a CD8+-T-lymphocyte reaction in vitro, to nanoparticles having an immobilized receptor unit, in particular an immobilized chain of an MHC molecule, to nanoparticles having an immobilized receptor, in particular an immobilized MHC molecule, to nanoparticles having an immobilized receptor/ligand complex, in particular a peptide-presenting MHC molecule, to a pType: ApplicationFiled: March 3, 2004Publication date: July 5, 2007Inventors: Herwig Brunner, Gunter Tover, Thomas Schiestel, Claudia Muller, Thomas Flad
-
Patent number: 7202472Abstract: The present invention relates to an improved method for mass spectrometric analysis, in particular for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using nanoparticles, where an analyte is added to a nanoparticle suspension, and the suspension containing the bound analyte is then deposited directly on a MALDI sample carrier and investigated by mass spectrometry, and to nanoparticles suitable for this method.Type: GrantFiled: August 16, 2002Date of Patent: April 10, 2007Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung e.V.Inventors: Jürgen Schmucker, Thomas Schiestel, Herwig Brunner, Günter Tovar
-
Patent number: 7070685Abstract: The invention relates to an efficient process and device for the decontamination of waters polluted with heavy metals, semimetals and/or radionuclides by cation exchange and electrochemical deposition of the anions.Type: GrantFiled: February 5, 2001Date of Patent: July 4, 2006Assignees: Fraunhofer-Gesellschaft, ATC Dr. MannInventors: Manfred Kühn, Herwig Brunner, Andreas Wolf, Günther Mann
-
Patent number: 6964697Abstract: A metal solution-diffusion membrane of a macroporous base on which a thin metal membrane layer is formed is disclosed. In the membrane, the base includes a hollow fiber with a metal material containing an intermediate layer being formed between the hollow fiber and the metal membrane layer. The metal solution-diffusion membrane can be made with a very thin metal membrane layer with high permeability and possesses long-term stability as well as a great separation surface/volume ratio. A method for producing a metal solution-diffusion membrane in which the intermediate layer serves to provide nuclei for the subsequent currentless deposition of the metal layer is also disclosed.Type: GrantFiled: July 3, 2002Date of Patent: November 15, 2005Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Xiulian Pan, Norbert Stroh, Herwig Brunner
-
Publication number: 20050048570Abstract: The present invention relates to functional elements that comprise microstructures containing biofunctionalized nanoparticles arranged on a carrier, a method for the production of these functional elements and the use thereof.Type: ApplicationFiled: December 27, 2002Publication date: March 3, 2005Inventors: Achim Weber, Thomas Schiestel, Gunter Tovar, Herwig Brunner, Steffen Rupp, Nicole Hauser
-
Publication number: 20050037516Abstract: The present invention relates to an improved method for mass spectrometric analysis, in particular for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using nanoparticles, where an analyte is added to a nanoparticle suspension, and the suspension containing the bound analyte is then deposited directly on a MALDI sample carrier and investigated by mass spectrometry, and to nanoparticles suitable for this method.Type: ApplicationFiled: August 16, 2002Publication date: February 17, 2005Inventors: Jurgen Schmucker, Thomas Schiestel, Herwig Brunner, Gunter Tovar
-
Publication number: 20050011359Abstract: The present invention relates to a metal solution-diffusion membrane of a macroporous base on which a thin metal membrane layer (3) is formed. In the present membrane, the base comprises a hollow fiber (1) with a metal material containing an intermediate layer (2) being formed between the hollow fiber (1) and the metal membrane layer (3). The invention further relates to a method for producing such a metal solution-diffusion membrane in which the intermediate layer (2) serves to provide nuclei for the subsequent currentless deposition of the metal layer (3). The present metal solution-diffusion membrane can be realized with a very thin metal membrane layer with high permeability and possesses great long-term stability as well as a great separation surface/volume ratio.Type: ApplicationFiled: July 3, 2002Publication date: January 20, 2005Inventors: Xiulian Pan, Norbert Stroh, Herwig Brunner
-
Publication number: 20040265392Abstract: The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.Type: ApplicationFiled: May 21, 2004Publication date: December 30, 2004Inventors: Gunter Tovar, Thomas Schiestel, Herwig Brunner, Klaus Pfizenmaier, Mattias Grell, Peter Scheurich, Angela Hammer
-
Patent number: RE43497Abstract: The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macrophage migration inhibitor factor) related diseases. In certain aspects, the present invention involves detecting MIF/Jab1 (c-Jun activation domain binding protein) interactions as a basis for modulating cellular regulatory pathways and for identifying candidate drugs for MIF-related diseases. The invention also provides methods for the identification of molecules which dissociate or prevent interaction or binding between MIF and Jab1.Type: GrantFiled: November 2, 2000Date of Patent: June 26, 2012Assignee: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Herwig Brunner, Jürgen Bernhagen, Robert Kleemann, Ralf Mischke, Afroditi Kapurniotu