Patents by Inventor Herwig Pongratz

Herwig Pongratz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors
    Patent number: 11384076
    Abstract: The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: July 12, 2022
    Assignees: UNIVERSITÄT REGENSBURG, UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
    Inventors: Siavosh Mahboobi, Andreas Sellmer, Herwig Pongratz, Bernardette Pilsl, Oliver Krämer, Thomas Kindler, Mandy Beyer
  • HDAC6 inhibitors, with improved solubility and their uses
    Patent number: 11198694
    Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and their use in the treatment of various diseases, such as cancer. The present invention further relates to methods for improvement of solubility by introducing basic substituents which offer the opportunity to create pharmaceutically acceptable salts. Moreover, it comprises methods of synthesizing the compounds and methods of treatment.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: December 14, 2021
    Assignee: UNIVERSITÄT REGENSBURG
    Inventors: Siavosh Mahboobi, Herwig Pongratz, Elisabeth Grünstein
  • NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES
    Publication number: 20200308174
    Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and their use in the treatment of various diseases, such as cancer. The present invention further relates to methods for improvement of solubility by introducing basic substituents which offer the opportunity to create pharmaceutically acceptable salts. Moreover, it comprises methods of synthesizing the compounds and methods of treatment.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 1, 2020
    Inventors: SIAVOSH MAHBOOBI, HERWIG PONGRATZ, ELISABETH GRÜNSTEIN
  • SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS
    Publication number: 20200190075
    Abstract: The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.
    Type: Application
    Filed: August 9, 2018
    Publication date: June 18, 2020
    Inventors: SIAVOSH MAHBOOBI, ANDREAS SELLMER, HERWIG PONGRATZ, BERNARDETTE PILSL, OLIVER KRÄMER, THOMAS KINDLER, MANDY BEYER
  • HDAC6 inhibitors and their uses
    Patent number: 10106540
    Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: October 23, 2018
    Assignees: UNIVERSITÄT REGENSBURG, FRIEDRICH-SCHILLER-UNIVERSITÄT JENA, UNIVERSITÄTSKLINIKUM JENA
    Inventors: Siavosh Mahboobi, Andreas Sellmer, Herwig Pongratz, Michel Leonhardt, Oliver Krämer, Frank-Dietmar Böhmer, Gerhard Kelter
  • NOVEL HDAC6 INHIBITORS AND THEIR USES
    Publication number: 20170210743
    Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).
    Type: Application
    Filed: August 4, 2015
    Publication date: July 27, 2017
    Inventors: Siavosh MAHBOOBI, Andreas SELLMER, Herwig PONGRATZ, Michel LEONHARDT, Oliver KRÄMER, Frank-Dietmar BÖHMER, Gerhard KELTER
  • Indole derivatives and their use for the treatment of malignant and other diseases based on pathological proliferation
    Patent number: 6812243
    Abstract: The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pathological cell proliferation.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: November 2, 2004
    Assignee: Zentaris AG
    Inventors: Siavosh Mahboobi, Sabine Kuhr, Herwig Pongratz, Alfred Popp, Harald Hufsky, Frank-D Bohmer, Steffen Teller, Andrea Uecker, Thomas Beckers
  • 2-acyl indole derivatives and their use as antitumor agents
    Publication number: 20030158216
    Abstract: The invention relates to novel indole and heteroindole derivatives of the formula I 1
    Type: Application
    Filed: October 24, 2002
    Publication date: August 21, 2003
    Applicant: Baxter Oncology GmbH
    Inventors: Thomas Beckers, Silke Bassner, Thomas Klenner, Siavosh Mahboobi, Herwig Pongratz, Markus Frieser, Harald Hufsky, Jorg Hockemeyer, Heinz-Herbert Fiebig, Angelika Burger, Frank-D. Bohmer
  • Indole derivatives and their use for the treatment of malignant and other diseases based on pathological proliferation
    Publication number: 20030008898
    Abstract: The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: 1
    Type: Application
    Filed: May 3, 2002
    Publication date: January 9, 2003
    Inventors: Siavosh Mahboobi, Sabine Kuhr, Herwig Pongratz, Alfred Popp, Harald Hufsky, Frank-D Bohmer, Steffen Teller, Andrea Uecker, Thomas Beckers
  • 2-acyl indole derivatives and their use as antitumor agents
    Publication number: 20020091124
    Abstract: The invention relates to novel indole and heteroindole derivatives of the formula I 1
    Type: Application
    Filed: April 27, 2001
    Publication date: July 11, 2002
    Inventors: Thomas Beckers, Silke Baasner, Thomas Klenner, Siavosh Mahboobi, Herwig Pongratz, Markus Frieser, Harald Hufsky, Jorg Hockemeyer, Heinz-Herbert Fiebig, Angelika Burger, Frank-D Bohmer
  • Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation
    Patent number: 6407102
    Abstract: The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pathological cell proliferation.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: June 18, 2002
    Assignee: Zentaris AG
    Inventors: Siavosh Mahboobi, Sabine Kuhr, Herwig Pongratz, Alfred Popp, Harald Hufsky, Frank-D Bohmer, Steffen Teller, Andrea Uecker, Thomas Beckers