Patents by Inventor Herwin Chan
Herwin Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9329173Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.Type: GrantFiled: January 7, 2010Date of Patent: May 3, 2016Assignee: Sensor-Kinesis CorporationInventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Leslie Farkas, Brett Jordan, Paladin Luboff, Herwin Chan, Kyle Zimmerman
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Patent number: 9310363Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.Type: GrantFiled: April 21, 2010Date of Patent: April 12, 2016Assignee: Sensor-Kinesis CorporationInventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Leslie Farkas, Brett Jordan, Paladin Luboff, Herwin Chan, Kyle Zimmerman
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Patent number: 8827986Abstract: A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.Type: GrantFiled: October 19, 2009Date of Patent: September 9, 2014Assignee: Pharmaco-Kinesis CorporationInventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Brett Jordan, Kyle Zimmerman, Herwin Chan, Winston Wu
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Patent number: 8571805Abstract: A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.Type: GrantFiled: June 22, 2010Date of Patent: October 29, 2013Assignee: Pharmaco-Kinesis CorporationInventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Brett Jordan, Kyle Zimmerman, Herwin Chan, Paladin Luboff
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Publication number: 20120245565Abstract: A method for utilizing a controlled pump implanted into a patient connected to a multilumen catheter allowing delivery to and sampling from the brain or other organ for treatment of a cancer. The pump delivers a plurality of medicating agents, including viral and non-viral vectors for gene therapy and cell therapy at a controlled rate, corresponding to the specific needs of the patient. A catheter is implanted in or adjacent to the tumoral region. Fluid drawn from the tumor region to the pump via the multilumen catheter is analyzed within the pump by various biofeedback sensors. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller. The method allows localized delivery of gene and cell therapy to a solid tumor or tumoral region, or to any other treatment area of interest within the patient.Type: ApplicationFiled: March 21, 2011Publication date: September 27, 2012Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Thomas C. Chen, Winston Wu, Brett Jordan, Herwin Chan, Kyle Zimmerman, Paladin Luboff
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Publication number: 20120041562Abstract: A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.Type: ApplicationFiled: October 27, 2011Publication date: February 16, 2012Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Brett Jordan, Kyle Zimmerman, Herwin Chan, Winston Wu
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Publication number: 20110295159Abstract: A vertebral processor designed to collect and interpret data from multiple surgically implanted accelerometers. Each accelerometer is surgically implanted into a vertebra of a patient utilizing a bone screw. Additional accelerometers are implanted in adjacent vertebrae. The data from the accelerometers is compared by an algorithm to determine the relative movement of the accelerometers implanted in adjacent vertebrae. Data is generated via the algorithm and compared against the expected behavior of the surgically implanted accelerometers as if they were connected to a rigid body, thus determining the level of success of a spinal fusion procedure for those adjacent segments. The apparatus may be utilized with or without spinal stabilization hardware, and with or without fusion cages or artificial discs. The vertebral processor is supplemented by an external system worn by the patient, which provides for an inductive charging power source and for data transfer.Type: ApplicationFiled: May 25, 2010Publication date: December 1, 2011Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Thomas Chen, Winston Wu, Brett Jordan, Herwin Chan, Paladin Luboff, Kyle Zimmerman
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Publication number: 20110162979Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.Type: ApplicationFiled: April 21, 2010Publication date: July 7, 2011Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Leslie Farkas, Brett Jordan, Paladin Luboff, Herwin Chan, Kyle Nichdas Zimmerman
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Publication number: 20110166033Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.Type: ApplicationFiled: January 7, 2010Publication date: July 7, 2011Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Leslie Farkas, Brett Jordan, Paladin Luboff, Herwin Chan, Kyle Zimmerman
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Publication number: 20110092948Abstract: The present disclosure describes a remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.Type: ApplicationFiled: October 19, 2009Publication date: April 21, 2011Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Thomas C. Chen, Leslie Farkas, Brett Jordan, Kyle Zimmerman, Herwin Chan, Winston Wu
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Publication number: 20100260679Abstract: A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.Type: ApplicationFiled: June 22, 2010Publication date: October 14, 2010Applicant: PHARMACO-KINESIS CORPORATIONInventors: Yehoshua Shachar, Winston Wu, Thomas Chen, Brett Jordan, Kyle Zimmerman, Herwin Chan, Paladin Luboff