Abstract: Methods for treating certain androgen receptor-positive forms of cancer using inhibitors of the CREB binding protein bromodomain are disclosed. In some methods, the AR-positive forms of cancer may be breast cancer, including triple negative forms, hormone receptor positive forms, and HER2-positive forms. In other methods, the AR-positive forms of cancer may be prostate cancer, including metastatic castration resistant prostate cancer. In some embodiments, methods of treating prostate cancer comprise the step of administering to a patient in need thereof the compound (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

Abstract: Methods for treating certain androgen receptor-positive forms of cancer using inhibitors of the CREB binding protein bromodomain are disclosed. In some methods, the AR-positive forms of cancer may be breast cancer, including triple negative forms, hormone receptor positive forms, and HER2-positive forms. In other methods, the AR-positive forms of cancer may be prostate cancer, including metastatic castration resistant prostate cancer. In some embodiments, methods of treating prostate cancer comprise the step of administering to a patient in need thereof the compound (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

Abstract: Administration regimens for anti-CD3 x anti-CD20 bispecific antibodies that mitigate cytokine release syndrome and infusion-related reaction are disclosed. The methods employ fractional dosing over several weeks of treatment along with administration of a steroid and an antihistamine.

Abstract: Methods for treating certain androgen receptor-positive forms of cancer using inhibitors of the CREB binding protein bromodomain are disclosed. In some methods, the AR-positive forms of cancer may be breast cancer, including triple negative forms, hormone receptor positive forms, and HER2-positive forms. In other methods, the AR-positive forms of cancer may be prostate cancer, including metastatic castration resistant prostate cancer. In some embodiments, methods of treating prostate cancer comprise the step of administering to a patient in need thereof the compound (1R,3R)-3-[(7S)-2-[(R)-(5-fluoro-2-methoxyphenyl)(hydroxy)methyl]-6-(methoxycarbonyl)-7-methyl-3H,6H,7H,8H,9H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid, or a pharmaceutically acceptable salt thereof.

Abstract: A user-customized method, system and computer program for automated translation from a source language and a target language. The user's native language and accent are detected, from which a set of phonemes is determined which are those that are difficult to pronounce for that user based on his or her native language and accent. A translation engine is applied to translate a fragment of the source language input into target language output, wherein the translation is performed with reference to the synonym database for the target language so as to preferentially avoid word strings in the output that contain phonemes that exist in the user's set of difficult-to-pronounce phonemes.

Abstract: A user-customized method, system and computer program for automated translation from a source language and a target language. The user's native language and accent are detected, from which a set of phonemes is determined which are those that are difficult to pronounce for that user based on his or her native language and accent. A translation engine is applied to translate a fragment of the source language input into target language output, wherein the translation is performed with reference to the synonym database for the target language so as to preferentially avoid word strings in the output that contain phonemes that exist in the user's set of difficult-to-pronounce phonemes.

Abstract: A robot for moving trash bins and recycle bins from a storage area typically garage or driveway, to a curbside for engagement by garbage/recycle collection truck and then later the robot returns the bins back to their storage area. This works best with the commonly used two-wheel bins. The robot detects the location of the bins using a camera and artificial intelligence and lifts the bins off the ground using an arm and hook to drag the bins on their wheels to the curbside one at a time. The robot may distinguish between types of bins, the owner bins and other's bins by a barcode sticker. The robot detects its directions from driveway to curbside by either a line drawn on the ground and detected by its camera or by using a training method that keeps track of images on its way and uses artificial intelligent.