Abstract: Methods and compositions for characterizing a biological sample (e.g., comprising an infectious agent) from a subject are provided. Methods can include detecting linkage of nucleic acids that are linked in a viable cell or organism but that become degraded and thus unlinked in inviable cells or organisms and then characterizing the subject based on the quantity of linked and unlinked sequences.

Abstract: The present disclosure relates to a rapid diagnostic test system that includes the prospective collection of whole blood, preservation of circulating nucleic acids at ambient temperature, and the reproducible detection of nucleic acids including DNA and mRNA (including fusion transcripts and differentially expressed transcripts) by different genomic methodologies.

Abstract: The present disclosure relates to devices, methods and kits for blood sample separation and analysis. More particularly, the disclosure relates to devices, methods and kits that rapidly separate a blood sample into uniform solid and liquid phases in a sealed environment. A specific example includes a device with a door coupled to the housing, a blood sample separation medium, a mesh material and a desiccant. In one example, the blood sample separation medium is disposed between the housing and the mesh material, the desiccant is coupled to the door, the desiccant is distal from the mesh material when the door is in a first open position, and the desiccant is proximal to the mesh material when the door is in a second closed position.

Abstract: The present disclosure relates to a rapid diagnostic test system that includes the prospective collection of whole blood, preservation of circulating nucleic acids at ambient temperature, and the reproducible detection of nucleic acids including DNA and mRNA (including fusion transcripts and differentially expressed transcripts) by different genomic methodologies.