Patents by Inventor Heun-Soo Kang

Heun-Soo Kang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210003582
    Abstract: The present invention relates to a method of improving the quality of therapeutic cells by real-time glutathione monitoring.
    Type: Application
    Filed: November 28, 2018
    Publication date: January 7, 2021
    Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Gwang Mo Yang, Ji Woong Shin, Hye Won Kang, Yong Hwan Kim, Myung Jin Kim
  • Publication number: 20200363422
    Abstract: The present invention provides a method of measuring the quality of therapeutic cells through real-time glutathione monitoring.
    Type: Application
    Filed: November 28, 2018
    Publication date: November 19, 2020
    Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Gwang Mo Yang, Ji Woong Shin, Hye Won Kang, Yong Hwan Kim, Myung Jin Kim
  • Publication number: 20200354388
    Abstract: The present invention relates to a real-time fluorescence imaging sensor for measuring glutathione in cell organelles and a method for fabricating the same. More specifically, the present invention relates to a novel compound for measuring glutathione in cell organelles, a method for preparing the novel compound, a real-time fluorescence imaging sensor for measuring glutathione in cell organelles, which comprises the novel compound, a method for fabricating the imaging sensor, and a method of measuring glutathione in cell organelles by use of the imaging sensor. When the composition comprising the compound according to the present invention is used, it can measure the antioxidant activity of the organelle mitochondria or Golgi apparatus in living cells, particularly stem cells, and can screen highly active stem cells based on the results obtained by measuring the antioxidant activity of the cell organelle.
    Type: Application
    Filed: August 23, 2018
    Publication date: November 12, 2020
    Inventors: Heun Soo Kang, Hye Mi Kim, Ji Eun Song, Myoung Jin Kim, Ki Hang Choi
  • Patent number: 10620215
    Abstract: The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: April 14, 2020
    Assignees: Cell2In, Inc., Korea University Reserach and Business Foundation, SNU R&DB Foundation
    Inventors: In-Gyu Kim, Ki Hang Choi, Eui Man Jeong, Heun Soo Kang
  • Publication number: 20190204331
    Abstract: The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
    Type: Application
    Filed: January 2, 2019
    Publication date: July 4, 2019
    Inventors: In-Gyu KIM, Ki Hang CHOI, Eui Man JEONG, Heun Soo KANG
  • Patent number: 10215757
    Abstract: The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: February 26, 2019
    Assignees: CELL2IN, INC., SNU R&DB FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: In-Gyu Kim, Ki Hang Choi, Eui Man Jeong, Heun Soo Kang
  • Patent number: 10087248
    Abstract: The present invention relates to a TNF-? (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-? specific antibody, is a bispecific antibody that effectively binds to both TNF-? and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-?/CXCL10. A composition of the present invention comprises a TNF-?/CXCL-10 double targeting antibody which effectively binds to both TNF-? and CXCL10. The double targeting antibody of the present invention has excellent TNF-? inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-? or CXCL10 single targeting antibody.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 2, 2018
    Assignee: METABOLIC ENGINEERING LABORATORIES CO., LTD.
    Inventors: Heun-Soo Kang, So-Hyun Park, Yeong Wook Song, Ki Chul Shin, Eun Young Lee, Eun Bong Lee, Young Woo Park, Bum-Chan Park, Dong Hee Lee, Dong Jin Kim, Seon Ha Yun, Ke Se Lee, Hyun Ju Lee, Kyung Jin Kim, Hee Chan Kim, Seok Ho Yoo, Myeoung Hee Jang, Seil Jang
  • Publication number: 20170307624
    Abstract: The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
    Type: Application
    Filed: November 18, 2015
    Publication date: October 26, 2017
    Inventors: In-Gyu KIM, Ki Hang CHOI, Eui Man JEONG, Heun Soo KANG
  • Publication number: 20160108118
    Abstract: The present invention relates to a TNF-? (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-? specific antibody, is a bispecific antibody that effectively binds to both TNF-? and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-?/CXCL10. A composition of the present invention comprises a TNF-?/CXCL-10 double targeting antibody which effectively binds to both TNF-? and CXCL10. The double targeting antibody of the present invention has excellent TNF-? inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-? or CXCL10 single targeting antibody.
    Type: Application
    Filed: May 22, 2014
    Publication date: April 21, 2016
    Applicant: METABOLIC ENGINEERING LABORATORIES CO., LTD.
    Inventors: Heun-Soo Kang, So-Hyun Park, Yeong Wook Song, Ki Chul Shin, Eun Young Lee, Eun Bong Lee, Young Woo Park, Bum-Chan Park, Dong Hee Lee, Dong Jin Kim, Seon Ha Yun, Ke Se Lee, Hyun Ju Lee, Kyung Jin Kim, Hee Chan Kim, Seok Ho Yoo, Myeoung Hee Jang, Seil Jang
  • Patent number: 7491768
    Abstract: The present invention relates to an anti-microbial or anti-coagulating polymer resin and a method for preparing the same, and a medical appliance or instrument using the same, and more particularly to a method for preparing an anti-microbial or anti-coagulating medical polymer resin comprising the steps of simply mixing a polymer resin with at least one kind of pharmaceutically active material without using a solvent. The pharmaceutically active material is preferably an anti-microbial or anti-coagulant. According to the present invention, an anti-microbial or anti-coagulating material that is safe to a human body is mixed with a polymer resin by simple addition in an environmentally favorable non-solvent method, thereby maintaining superior anti-microbial effects even after high temperature molding, minimizing a released amount of anti-microbial to increase anti-microbial effect durability, and solving a toxic problem in a body.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: February 17, 2009
    Inventors: Woong-Sig Moon, Jae-Chul Kim, Youn-Seop Byoun, Kyoo-Hyun Chung, Heun-Soo Kang, Ki-Oh Kong, Jung-Hwa Hwang
  • Publication number: 20050245671
    Abstract: The present invention relates to an anti-microbial or anti-coagulating polymer resin and a method for preparing the same, and a medical appliance or instrument using the same, and more particularly to a method for preparing an anti-microbial or anti-coagulating medical polymer resin comprising the steps of simply mixing a polymer resin with at least one kind of pharmaceutically active material without using a solvent. The pharmaceutically active material is preferably an anti-microbial or anti-coagulant. According to the present invention, an anti-microbial or anti-coagulating material that is safe to a human body is mixed with a polymer resin by simple addition in an environmentally favorable non-solvent method, thereby maintaining superior anti-microbial effects even after high temperature molding, minimizing a released amount of anti-microbial to increase anti-microbial effect durability, and solving a toxic problem in a body.
    Type: Application
    Filed: June 25, 2003
    Publication date: November 3, 2005
    Inventors: Woeng-Sig Moon, Jae-Chul Kim, Youn-Seop Byoun, Kyoo-Hyun Chung, Heun-Soo Kang, Ki-Oh Kong, Jung-Hwa Hwang
  • Publication number: 20050084553
    Abstract: The present invention relates to a composition comprising a Moutan root bark extract as an active ingredient, and particularly to a composition for the prevention and treatment of athlete's foot, osmidrosis, or acne; a composition for oral cleansing; a bactericidal/disinfectant composition; a composition for eliminating dandruff-causing pathogens and controlling odor, and a functional kitchen detergent composition. The compositions comprising the Moutan root bark extract as an active ingredient of the present invention have superior bactericidal effects against bacteria including athlete's foot-causing pathogens, skin eczema-causing pathogens and skin flora, and fungi, and they can be easily and simply applied to medicines, cosmetics, or cleansing agents.
    Type: Application
    Filed: January 24, 2003
    Publication date: April 21, 2005
    Inventors: Woong-Sig Moon, Jae-Chul Kim, Heun-Soo Kang, Seong-Min Sohn