Abstract: A wearable probe includes a sensor module and a control module. The sensor module includes a transmission source to transmit signals into the tissue at a source position, and two detectors to detect a result of the signals, the two detectors including a first detector positioned at a first separation distance from the source position and a second detector positioned at a second separation distance from the source position. The control module includes a controller and a battery to power the controller and the sensor module. The control module includes a processor, a memory including instructions, and a communications interface. The instructions cause the processor to control the sensor module to transmit signals into the tissue and detect results of the signals with the at least two detectors, receive the detected results, store the detected results in the memory, and transmit the detected results to a remote device.

Abstract: A wearable probe includes a sensor module and a control module. The sensor module includes a transmission source to transmit signals into the tissue at a source position, and two detectors to detect a result of the signals, the two detectors including a first detector positioned at a first separation distance from the source position and a second detector positioned at a second separation distance from the source position. The control module includes a controller and a battery to power the controller and the sensor module. The control module includes a processor, a memory including instructions, and a communications interface. The instructions cause the processor to control the sensor module to transmit signals into the tissue and detect results of the signals with the at least two detectors, receive the detected results, store the detected results in the memory, and transmit the detected results to a remote device.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Abstract: A wearable probe includes a sensor module and a control module. The sensor module includes a transmission source to transmit signals into the tissue at a source position, and two detectors to detect a result of the signals, the two detectors including a first detector positioned at a first separation distance from the source position and a second detector positioned at a second separation distance from the source position. The control module includes a controller and a battery to power the controller and the sensor module. The control module includes a processor, a memory including instructions, and a communications interface. The instructions cause the processor to control the sensor module to transmit signals into the tissue and detect results of the signals with the at least two detectors, receive the detected results, store the detected results in the memory, and transmit the detected results to a remote device.

Abstract: Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Abstract: Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.