Patents by Inventor Hexiang Wang

Hexiang Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250053484
    Abstract: The present disclosure relates to a data recovery method, a storage medium, and an electronic device. The method includes: receiving a notification message sent by a computing node in a distributed graph computing system, where the notification message represents that the corresponding computing node successfully stores current checkpoint data in a persistent memory; generating a checkpoint identifier corresponding to a current checkpoint when determining that all computing nodes in the distributed graph computing system successfully store the current checkpoint data in respective persistent memories; and sending the checkpoint identifier to each computing node, so that each computing node associates the checkpoint identifier with the current checkpoint data stored in the persistent memory, and the associated current checkpoint data is used for data recovery during recovery execution before the corresponding computing node obtains a checkpoint identifier corresponding to a next checkpoint.
    Type: Application
    Filed: July 22, 2024
    Publication date: February 13, 2025
    Inventors: Miaomiao CHENG, Jiujian CHEN, Cheng ZHAO, Cheng CHEN, Yongmin HU, Xiaoliang CONG, Liang QIN, Hexiang LIN, Ronghua LI, Guoren WANG, Shuai ZHANG, Lei ZHANG
  • Publication number: 20250041645
    Abstract: A fire extinguishing control method, a fire extinguishing system, and a storage medium are provided. The fire extinguishing protection system includes a fire extinguishing system and a device to be protected. The fire extinguishing system (3) is configured to extinguish a fire in the device to be protected (2). The fire extinguishing system includes a fire extinguishing apparatus. The fire extinguishing control method is applied to the fire extinguishing system. Flame feature data of at least one preset portion of the device to be protected is obtained. A processing mode of the fire extinguishing apparatus is determined according to the flame feature data of the at least one preset portion in the case that presence of a flame is determined according to the flame feature data of the at least one preset portion. The fire extinguishing apparatus is controlled to perform a corresponding operation according to the determined processing mode.
    Type: Application
    Filed: October 23, 2024
    Publication date: February 6, 2025
    Applicant: Makeblock Co., Ltd.
    Inventors: Binquan WANG, Hexiang GAN, Shangzheng XIE
  • Publication number: 20250034197
    Abstract: The invention concerns compounds of Formula (X) which modulate, especially agonize alpha kinase 1 (ALPK1) and are useful for treating a condition, disease or disorder in which a decrease or increase in ALPK1 activity contributes to the pathology or symptoms or progression of the condition, disease or disorder such as cancer, immune or inflammatory related diseases.
    Type: Application
    Filed: September 29, 2022
    Publication date: January 30, 2025
    Inventors: Nana Du, Counde O'Yang, Hexiang Wang, Zhihong Li
  • Publication number: 20240366770
    Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
    Type: Application
    Filed: June 28, 2024
    Publication date: November 7, 2024
    Applicant: BeiGene Switzerland GmbH
    Inventors: Changxin HUO, Hexiang WANG, Zhemin CHEN, Zhiwei WANG, Huaqing LIU
  • Publication number: 20240366769
    Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
    Type: Application
    Filed: June 28, 2024
    Publication date: November 7, 2024
    Applicant: BeiGene Switzerland GmbH
    Inventors: Changxin HUO, Hexiang WANG, Ruipeng QI, Zhiwei WANG, Huaqing LIU
  • Publication number: 20240246977
    Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
    Type: Application
    Filed: December 30, 2021
    Publication date: July 25, 2024
    Inventors: Changxin HUO, Hexiang WANG, GAng LV, Zhiwei WANG, Huaqing LIU
  • Patent number: 11950763
    Abstract: Disclosed is a self-propelled soft robot body, including a tube which is internally and axially provided with a tube cavity, and at least one propelling structure, comprising a first driving unit, a second driving unit and a third driving unit, which are evenly fixed on a peripheral wall of the tube cavity, relative to an axis thereof, and along the axis of the tube; and the first driving unit, the second driving unit and the third driving unit are respectively telescopic along the axis of the tube; at least two support structures, with each two adjacent support structures having at least one propelling structure arranged therebetween, the support structures are fixedly connected with the propelling structure and arranged on the peripheral wall of the tube cavity.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: April 9, 2024
    Assignee: Tsinghua University
    Inventors: Hongen Liao, Boyu Zhang, Hexiang Wang, Tiantian Zhang
  • Publication number: 20230322761
    Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
    Type: Application
    Filed: March 10, 2021
    Publication date: October 12, 2023
    Inventors: Hexiang WANG, Bailin LEI, Changxin HUO, Dongqing SUN, Jie CHEN, Zhiwei WANG
  • Publication number: 20230167118
    Abstract: Bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 1, 2023
    Inventors: Hexiang WANG, Bailin LEI, Changxin HUO, Dongqing SUN, Jie CHEN, Zhiwei WANG, Yucheng WANG
  • Patent number: 11472788
    Abstract: Disclosed herein are novel benzoimidazoles and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain novel benzoimidazoles that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Grant
    Filed: November 24, 2018
    Date of Patent: October 18, 2022
    Assignee: BEIGENE, LTD.
    Inventors: Hexiang Wang, Yunhang Guo, Zhiwei Wang, Changyou Zhou
  • Publication number: 20220281876
    Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 8, 2022
    Inventors: Hexiang WANG, Changxin HUO, Yunhang GUO, Ruipeng QI, Zhiwei WANG
  • Publication number: 20220227762
    Abstract: Disclosed herein are amide-substituted imidazo compounds and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain amide-substituted imidazo compounds that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Application
    Filed: May 21, 2020
    Publication date: July 21, 2022
    Inventors: Hexiang WANG, Ming QIU, Changyou ZHOU
  • Patent number: 11202782
    Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: December 21, 2021
    Assignee: BEIGENE, LTD.
    Inventors: Lai Wang, Zhiyu Tang, Lusong Luo, Min Wei, Kang Li, Jing Song, Tong Zhang, Hexiang Wang, Bo Ren, Changyou Zhou
  • Publication number: 20210205323
    Abstract: Disclosed herein is a method for maintenance therapy of a PARP inhibitor in treating a subject with gastric cancer (GC) comprising administering to the subject a therapeutic or maintenance effective amount of a PARP inhibitor, wherein the subject had previously received chemotherapy.
    Type: Application
    Filed: May 31, 2019
    Publication date: July 8, 2021
    Inventors: Beibei JIANG, Rainer K. BRACHMANN, Yuting ZHANG, Mitch RAPONI, Heinrich FARIN, Lai WANG, Hexiang WANG
  • Patent number: 10899763
    Abstract: Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: January 26, 2021
    Assignee: BEIGENE, LTD.
    Inventors: Hexiang Wang, Xianzhao Kuang, Changyou Zhou
  • Patent number: 10882856
    Abstract: Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Grant
    Filed: September 23, 2017
    Date of Patent: January 5, 2021
    Assignee: BEIGENE, LTD.
    Inventors: Hexiang Wang, Yunhang Guo, Bo Ren, Zhiwei Wang, Guoliang Zhang, Changyou Zhou
  • Publication number: 20200317638
    Abstract: Disclosed herein are novel benzoimidazoles and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain novel benzoimidazoles that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
    Type: Application
    Filed: November 24, 2018
    Publication date: October 8, 2020
    Inventors: Hexiang WANG, Yunhang GUO, Zhiwei WANG, Changyou ZHOU
  • Publication number: 20200221938
    Abstract: Disclosed is a self-propelled soft robot body, including a tube which is internally and axially provided with a tube cavity, and at least one propelling structure, comprising a first driving unit, a second driving unit and a third driving unit, which are evenly fixed on a peripheral wall of the tube cavity, relative to an axis thereof, and along the axis of the tube; and the first driving unit, the second driving unit and the third driving unit are respectively telescopic along the axis of the tube; at least two support structures, with each two adjacent support structures having at least one propelling structure arranged therebetween, the support structures are fixedly connected with the propelling structure and arranged on the peripheral wall of the tube cavity.
    Type: Application
    Filed: January 14, 2020
    Publication date: July 16, 2020
    Inventors: Hongen Liao, Boyu Zhang, Hexiang Wang, Tiantian Zhang
  • Publication number: 20200155567
    Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with temozolomide and/or radiation therapy. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7, 8, 9, 10, 10a, 11-hexahydro-5, 6, 7a, 11-tetraazacyclohepta [def] cyclopenta [a] fluoren-4 (5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with temozolomide and the use thereof.
    Type: Application
    Filed: July 17, 2018
    Publication date: May 21, 2020
    Inventors: Lai WANG, Zhiyu TANG, Lusong LUO, Min WEI, Amy PETERSON, Hexiang WANG, Bo REN, Changyou ZHOU
  • Publication number: 20200157103
    Abstract: Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.
    Type: Application
    Filed: February 27, 2018
    Publication date: May 21, 2020
    Inventors: Hexiang WANG, Xianzhao KUANG, Changyou ZHOU