Abstract: Some embodiments of the disclosure provide methods for calculating carbon footprints of leather chemical materials. In some examples, the method includes: determining a calculation range of a carbon footprint of a leather chemical material in a life cycle as “cradle to gate”; determining a system boundary, a functional unit, and cut-off criteria for the carbon footprint of the leather chemical material in the life cycle; dividing the carbon footprint into a raw chemical obtaining process, a production process of the leather chemical material, and a waste disposal process within the system boundary; determining a carbon footprint calculation model for the leather chemical material according to resource consumption and environmental emission of each process; collecting and determining a quantity and a value required by each parameter in the carbon footprint calculation model; and calculating the carbon footprint of the leather chemical material using the carbon footprint calculation model.

Abstract: A power-off protection apparatus and a power-off protection system are provided. The power-off protection apparatus is applied to the power-off protection system. The power-off protection system includes a laser machining device and a power control device. The power-off protection apparatus, the laser machining device, and the power control device are in communication connection. The laser machining device is powered on by the power control device. The power-off protection apparatus is configured to send a final encoded power-off signal to the power control device, to cause the power control device to perform a power-off operation to power off the laser machining device.

Abstract: The present disclosure relates to a data recovery method, a storage medium, and an electronic device. The method includes: receiving a notification message sent by a computing node in a distributed graph computing system, where the notification message represents that the corresponding computing node successfully stores current checkpoint data in a persistent memory; generating a checkpoint identifier corresponding to a current checkpoint when determining that all computing nodes in the distributed graph computing system successfully store the current checkpoint data in respective persistent memories; and sending the checkpoint identifier to each computing node, so that each computing node associates the checkpoint identifier with the current checkpoint data stored in the persistent memory, and the associated current checkpoint data is used for data recovery during recovery execution before the corresponding computing node obtains a checkpoint identifier corresponding to a next checkpoint.

Abstract: A fire extinguishing control method, a fire extinguishing system, and a storage medium are provided. The fire extinguishing protection system includes a fire extinguishing system and a device to be protected. The fire extinguishing system (3) is configured to extinguish a fire in the device to be protected (2). The fire extinguishing system includes a fire extinguishing apparatus. The fire extinguishing control method is applied to the fire extinguishing system. Flame feature data of at least one preset portion of the device to be protected is obtained. A processing mode of the fire extinguishing apparatus is determined according to the flame feature data of the at least one preset portion in the case that presence of a flame is determined according to the flame feature data of the at least one preset portion. The fire extinguishing apparatus is controlled to perform a corresponding operation according to the determined processing mode.

Abstract: The invention concerns compounds of Formula (X) which modulate, especially agonize alpha kinase 1 (ALPK1) and are useful for treating a condition, disease or disorder in which a decrease or increase in ALPK1 activity contributes to the pathology or symptoms or progression of the condition, disease or disorder such as cancer, immune or inflammatory related diseases.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed is a self-propelled soft robot body, including a tube which is internally and axially provided with a tube cavity, and at least one propelling structure, comprising a first driving unit, a second driving unit and a third driving unit, which are evenly fixed on a peripheral wall of the tube cavity, relative to an axis thereof, and along the axis of the tube; and the first driving unit, the second driving unit and the third driving unit are respectively telescopic along the axis of the tube; at least two support structures, with each two adjacent support structures having at least one propelling structure arranged therebetween, the support structures are fixedly connected with the propelling structure and arranged on the peripheral wall of the tube cavity.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed herein are novel benzoimidazoles and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain novel benzoimidazoles that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed herein are amide-substituted imidazo compounds and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain amide-substituted imidazo compounds that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Abstract: Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a chemotherapeutic agent. Also, disclosed a pharmaceutical combination comprising a PARP inhibitor, particularly, (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, a sesqui-hydrate thereof, or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a chemotherapeutic agent and the use thereof.

Abstract: Disclosed herein is a method for maintenance therapy of a PARP inhibitor in treating a subject with gastric cancer (GC) comprising administering to the subject a therapeutic or maintenance effective amount of a PARP inhibitor, wherein the subject had previously received chemotherapy.

Abstract: Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.

Abstract: Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Abstract: Disclosed herein are novel benzoimidazoles and pharmaceutical compositions comprising at least one such novel benzoimidazoles, processes for the preparation thereof, and the method for using the same in therapy. In particular, disclosed herein are certain novel benzoimidazoles that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Abstract: Disclosed is a self-propelled soft robot body, including a tube which is internally and axially provided with a tube cavity, and at least one propelling structure, comprising a first driving unit, a second driving unit and a third driving unit, which are evenly fixed on a peripheral wall of the tube cavity, relative to an axis thereof, and along the axis of the tube; and the first driving unit, the second driving unit and the third driving unit are respectively telescopic along the axis of the tube; at least two support structures, with each two adjacent support structures having at least one propelling structure arranged therebetween, the support structures are fixedly connected with the propelling structure and arranged on the peripheral wall of the tube cavity.