Abstract: A single-use syringe comprises a barrel having a proximal end, a distal end and an inside surface, and a plunger rod having a proximal portion and a distal portion connected by a disengageable connection. The plunger rod further includes a stopper on its distal end. The disengageable connection is strong enough to hold the proximal and distal portions together during normal use of the syringe and disengageable upon application of an additional force applied to the proximal portion. A catch on the proximal portion of the plunger rod and a discontinuity in the chamber engage to prevent removal of the proximal portion from the barrel.