Patents by Inventor Hidde Jacob Haisma

Hidde Jacob Haisma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Esters Of Glucuronide Prodrugs Of Anthracyclines And Method Of Preparation And Use In Tumor-Selective Chemotherapy
    Publication number: 20090227617
    Abstract: The invention relates to novel esters and in particular to some novel esters of glucuronide prodrugs of anthracyclines having tunable water-solubility, their synthesis and use in tumor-selective chemotherapy. It appeared that in the final step in the synthesis of these prodrugs, i.e. the coupling of the glucuronide spacer moiety to the parent drug molecule, protection of the sugar hydroxyls is, surprisingly, no longer required. A process for the preparation of these unprotected sugar spacer moieties is also disclosed.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 10, 2009
    Applicant: Pharmachemie B.V.
    Inventors: Rene Wilhelmus Marie Aben, Johan Wilhelm Scheeren, Jeroen Johannes Lambertus Maria Cornelissen, Dick De Vos, Hidde Jacob Haisma