Abstract: A method produces a hairpin single-stranded RNA molecule capable of inhibiting expression of a target gene, including the step of reacting a first single-stranded oligo-RNA molecule represented by formula (I) with a second single-stranded oligo-RNA molecule represented by formula (II) in a mixed solvent including a buffer solution and a hydrophilic organic solvent in the presence of a dehydration condensation agent: 5?-Xc-Lx1 . . . (I) and Lx2-X—Y-Ly-Yc-3? . . . (II), wherein the dehydration condensation agent is selected from the group consisting of a triazine-based dehydration condensation agent, a uronium-based dehydration condensation agent including an N-hydroxy nitrogen-containing aromatic ring structure, a carbodiimide-based dehydration condensation agent, a 2-halopyridinium-based dehydration condensation agent, and a formamidinium-based dehydration condensation agent.

Abstract: The present disclosure provides a MEMS device having a movable portion. The MEMS device includes: a substrate; a recess, disposed in the substrate; the movable portion, hollowly supported in the recess; and a bump stop, hollowly supported in the recess and configured to restrict a movement of the movable portion by contacting the movable portion. The bump stop includes: a protruding portion, configured to contact the movable portion; and a shock absorbing portion, disposed between the protruding portion and the substrate and configured to absorb at least a part of an impact force applied to the protruding portion by elastic deformation.

Abstract: A method for producing fluorenone including a pretreatment step of heating fluorene in the presence of a lower aliphatic carboxylic acid, a bromine compound, and a metal catalyst, and an oxidation step of continuously supplying fluorene and oxygen to perform an oxidation reaction, in the order indicated.

Abstract: Provided is a method for producing fluorenone comprising an oxidation step of oxidizing fluorene in the presence of an aliphatic carboxylic acid having 2 to 3 carbon atoms, a metal catalyst, a bromine compound, and oxygen, a solvent removal step of removing the aliphatic carboxylic acid, a heating step at 120 to 350° C., and a distillation step in the order indicated.

Abstract: A non-aqueous electrolyte secondary battery includes at least a positive electrode active material layer, a porous film, and a negative electrode active material layer. The negative electrode active material layer contains at least a graphite-based carbon material and silicon oxide. The porous film is interposed between the positive electrode active material layer and the negative electrode active material layer. The porous film contains at least a ceramic material. The negative electrode active material layer has a first spring constant. The porous film has a second spring constant. A ratio of the second spring constant to the first spring constant is higher than 1.

Abstract: A valve device includes: valves configured to control a flow of processing gases supplied to a process vessel; a housing in which first flow paths through which the processing gases flow are formed; a heat diffuser configured to cover the housing and diffuse heat of the housing; a heating part configured to cover the housing covered with the heat diffuser and heat the housing via the heat diffuser; a supply configured to supply a coolant to a second flow path formed between the housing and the heat diffuser; and a controller configure to control the heating part to heat the housing to a first temperature when a predetermined process is performed on a target substrate, and before a start of a cleaning process of the process vessel, control the heating part to stop heating of the housing and control the supply to supply the coolant to the second flow path.

Abstract: A non-aqueous electrolyte secondary battery includes: a pressure-type current interrupt device arranged in a conductive path, for interrupting the conductive path when an internal pressure exceeds a working pressure; a non-aqueous electrolyte; and a positive electrode composite material layer. The non-aqueous electrolyte contains a gas generation agent that generates a gas in an overcharge region, and the positive electrode composite material layer contains a first positive electrode active material particle including lithium iron phosphate, and a second positive electrode active material particle including lithium-nickel composite oxide. A ratio of the first positive electrode active material particle to a total mass of the first positive electrode active material particle and the second positive electrode active material particle is 5% by mass or more and 20% by mass or less.

Abstract: A nonaqueous electrolyte secondary battery according to the present invention includes: an electrode body including a positive electrode including a positive-electrode active material layer; an external terminal connected to the electrode body; a nonaqueous electrolyte including a gas generant, and a current interrupt device. A content of the gas generant is at least 4 mass %. The positive-electrode active material layer includes, as a positive-electrode active material, a complex oxide containing at least zirconium (Zr) and calcium (Ca) as constituent elements. When a sum total of metal elements, except metal that becomes a charge carrier, in the complex oxide is 100 mol % in terms of a mole percentage, the complex oxide contains Zr from 0.1 mol % to 0.5 mol % inclusive and Ca from 0.1 mol % to 0.3 mol % inclusive.

Abstract: A method of producing a lithium ion secondary battery includes preparing a case in which an electrode group including at least a positive electrode and a negative electrode is accommodated; impregnating a first electrolyte solution into the electrode group, lowering a potential of the negative electrode to a first potential, injecting FEC into a case, and lowering a potential of the negative electrode to a second potential. The negative electrode contains at least graphite and silicon oxide. The first electrolyte solution does not contain FEC. An additive has a reductive decomposition potential of 0.5 V (vs. Li+/Li) or more and 1.5 V (vs. Li+/Li) or less. The first potential is higher than 0.2 V (vs. Li+/Li) and is equal to or lower than the reductive decomposition potential. The second potential is 0.2 V (vs. Li+/Li) or less.

Abstract: Disclosed herein is a method for producing high-purity terephthalic acid, including steps of dissolving crude terephthalic acid crystal in water and performing catalytic hydrogenation treatment, depressurizing and cooling a reaction liquid after the catalytic hydrogenation treatment in stages with two or more stages of crystallization vessels, to crystallize terephthalic acid to obtain a terephthalic acid slurry, introducing the terephthalic acid slurry into an upper portion of a mother liquor replacement tower, bringing the terephthalic acid crystal into contact with an upward flow of replacement water introduced from a tower lower compartment of the mother liquor replacement tower while making the terephthalic acid crystal settled down in the tower, withdrawing the terephthalic acid crystal as slurry with the replacement water from the tower lower compartment, subjecting the slurry withdrawn from the tower lower compartment to solid-liquid separation into water and the terephthalic acid crystal, and drying

Abstract: A valve device includes: valves configured to control a flow of processing gases supplied to a process vessel; a housing in which first flow paths through which the processing gases flow are formed; a heat diffuser configured to cover the housing and diffuse heat of the housing; a heating part configured to cover the housing covered with the heat diffuser and heat the housing via the heat diffuser; a supply configured to supply a coolant to a second flow path formed between the housing and the heat diffuser; and a controller configure to control the heating part to heat the housing to a first temperature when a predetermined process is performed on a target substrate, and before a start of a cleaning process of the process vessel, control the heating part to stop heating of the housing and control the supply to supply the coolant to the second flow path.

Abstract: A method of manufacturing a non-aqueous electrolyte secondary battery includes: (A) constructing an electrode group including a positive electrode and a negative electrode; (B) impregnating the electrode group with a first electrolyte solution; (C) charging the electrode group impregnated with the first electrolyte solution to a voltage of 4.3 V or more; and (E) manufacturing the non-aqueous electrolyte secondary battery by impregnating the electrode group with a second electrolyte solution after the charging. The first electrolyte solution includes a first solvent, a first lithium salt, and biphenyl. The first solvent does not include 1,2-dimethoxyethane. The second electrolyte solution includes a second solvent and a second lithium salt. The second solvent includes 1,2-dimethoxyethane.

Abstract: In an electrode body for use in non-aqueous electrolyte secondary battery, a first end of a separator is located more interiorly than one positive electrode end of a positive electrode plate in a width direction, located more exteriorly than one end of a coated positive electrode portion of the positive electrode plate, and located more exteriorly than one end of a coated negative electrode portion of a negative electrode plate. The first end of the separator is thicker than an intermediate portion. A second end of the separator is located more interiorly than an other negative electrode end of the negative electrode plate in the width direction, located more exteriorly than the other end of the coated positive electrode portion of the positive electrode plate, and located more exteriorly than an other end of the coated negative electrode portion of the negative electrode plate. The second end of the separator is thicker than the intermediate portion.

Abstract: A lithium-ion secondary battery (100) includes a wound electrode body (80), a nonaqueous electrolyte, and a box-shaped case (50). The wound electrode body includes a positive electrode (10), a negative electrode (20), and a separator (40). The box-shaped case contains the wound electrode body and the nonaqueous electrolyte. The wound electrode body includes a starting-end-side negative electrode remainder portion (22) provided in a winding-direction starting end portion (81) of the wound electrode body. The winding-direction starting end portion exists at a winding center side. The starting-end-side negative electrode remainder portion protrudes toward the winding center side along a winding direction beyond the positive electrode. A surplus nonaqueous electrolyte exists in a gap between the wound electrode body and the box-shaped case.

Abstract: A method of terephthalic acid production in which slurry of crude terephthalic acid obtained through liquid-phase oxidation of a p-phenylene compound or a terephthalic acid slurry resulting from catalytic hydrogenation of the crude terephthalic acid is introduced into an upper part of a dispersion medium replacement tower while a second dispersion medium for replacement is introduced from a lower part of the dispersion medium replacement tower to perform dispersion medium replacement. The method is capable of enabling the dispersion medium replacement tower to continue stable operation while maintaining an extremely high efficiency of dispersion medium replacement.

Abstract: A method for producing high-purity terephthalic acid, comprising following steps (a) to (e): (a) a step of obtaining a crude terephthalic acid crystal by liquid-phase oxidizing a p-phenylene compound, (b) a step of dissolving the crude terephthalic acid crystal in water and then subjecting to catalytic hydrogenation treatment, (c) a step of depressurizing and cooling a reaction liquid after the catalytic hydrogenation treatment in stages with two or more stages of crystallization vessels, to crystallize terephthalic acid to obtain a terephthalic acid slurry, (d) a step of introducing the terephthalic acid slurry into an upper portion of a mother liquor replacement tower, bringing the terephthalic acid crystal into contact with an upward flow of replacement water introduced from a tower lower compartment of the mother liquor replacement tower while making the terephthalic acid crystal settled down in the tower, and withdrawing the terephthalic acid crystal as slurry with the replacement water from the tower

Abstract: A method of terephthalic acid production in which slurry of crude terephthalic acid obtained through liquid-phase oxidation of a p-phenylene compound or a terephthalic acid slurry resulting from catalytic hydrogenation of the crude terephthalic acid is introduced into an upper part of a dispersion medium replacement tower while a second dispersion medium for replacement is introduced from a lower part of the dispersion medium replacement tower to perform dispersion medium replacement. The method is capable of enabling the dispersion medium replacement tower to continue stable operation while maintaining an extremely high efficiency of dispersion medium replacement.

Abstract: A non-aqueous electrolyte secondary battery includes at least a positive electrode active material layer, a porous film, and a negative electrode active material layer. The negative electrode active material layer contains at least a graphite-based carbon material and silicon oxide. The porous film is interposed between the positive electrode active material layer and the negative electrode active material layer. The porous film contains at least a ceramic material. The negative electrode active material layer has a first spring constant. The porous film has a second spring constant. A ratio of the second spring constant to the first spring constant is higher than 1.

Abstract: A method for producing high-purity terephthalic acid, comprising following steps (a) to (c): the step (a); obtaining crude terephthalic acid crystal by liquid phase-oxidizing a p-phenylene compound; the step (b); obtaining a terephthalic acid crystal slurry by a catalytic hydrogenation treatment of the crude terephthalic acid crystal; and the step (c); introducing the terephthalic acid crystal slurry into an upper portion of a mother liquor replacement tower, and bringing the slurry into contact with an upward flow of replacement water introduced from a bottom portion of the mother liquor replacement tower while making the terephthalic acid crystal settled down in the tower, and extracting the terephthalic acid crystal as a slurry with the replacement water from the tower bottom portion, wherein (1) a stirring blade unit is disposed in a slurry layer in the bottom portion of the mother liquor replacement tower, and fluidity of the slurry layer is maintained by rotating the stirring blade unit in such a way

Abstract: A positive electrode and a negative electrode are stacked so as to face each other with a separator and a low spring constant film interposed therebetween. The positive electrode or the negative electrode has a first spring constant that is the lowest spring constant of the positive electrode, the negative electrode and the separator. The low spring constant film has a second spring constant. The second spring constant is lower than the first spring constant.