Patents by Inventor Hideaki Nagase

Hideaki Nagase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOTAM DERIVATIVES FOR THERAPEUTIC USE
    Publication number: 20170050988
    Abstract: A compound of formula (I), a stereoisomeric form thereof, or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein, is provided. The compounds of formula (I) are valuable pharmacologically active compounds and are suitable for the treatment of osteoarthritis. The preparation of the compounds of formula (I), their use as pharmaceuticals, and pharmaceutical compositions including them are also provided.
    Type: Application
    Filed: November 25, 2014
    Publication date: February 23, 2017
    Applicants: SANOFI, EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Hai-Yu HU, Marc NAZARE, Ngee HAN LIM, Danping DING-PFENNIGDORFF, Oliver PLETTENBURG, Olaf RITZELER, Hans-Paul JURETSCHKE, Joachim SAAS, Eckart BARTNIK, Peter FLORIAN, Ulrich WENDT, Carsten SCHULTZ, Hideaki NAGASE
  • Compounds
    Publication number: 20090318342
    Abstract: A mutant TIMP-3 (Tissue Inhibitor of MetalloProteinase-3) polypeptide wherein an additional residue or residues, for example an alanine residue, precedes the N-terminal residue of the TIMP-3 polypeptide; or wherein the residue corresponding to Threonine2 of TIMP-3 is mutated to Glycine. Such a mutant is considered to retain activity as an inhibitor of ADAMs, such as TACE, ADAMTS-4 and ADAMTS-5, but to have reduced activity as an inhibitor of MMPs.
    Type: Application
    Filed: July 28, 2006
    Publication date: December 24, 2009
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Hideaki Nagase, Keith Brew
  • Discriminatory substrates for MMP hydrolysis
    Patent number: 5770691
    Abstract: A method of screening a sample for the presence of a matrix metalloproteinase employing discriminatory peptide substrates is provided. The method involves providing a peptide substrate of 6-14 amino acid residues containing at least one matrix metalloproteinase cleavage site. The peptide substrate contains Mca as a fluorogenic group and Lys(Dnp) as a quenching group separated by at least four amino acid residues, wherein the peptide substrate is specific for the matrix metalloproteinase of interest. The peptide substrate is combined with a sample containing at least one matrix metalloproteinase to form a mixture. The fluorescence of the mixture is monitored to determine if the matrix metalloproteinase of interest is present.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 23, 1998
    Assignees: Regents of the University of Minnesota, The University of Kansas Medical Center
    Inventors: Gregg B. Fields, Hideaki Nagase
  • cDNA clones encoding chicken egg white cystatin
    Patent number: 5212297
    Abstract: cDNA clones coding for the chicken cysteine proteinase inhibitor cystatin were found and isolated using for example a synthetic oligonucleotide probe corresponding to amino acids 81-90 of the cystatin sequence. This was used to screen a lambda gt 11 chicken oviduct cDNA library. A full length cystatin cDNA was also isolated.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: May 18, 1993
    Assignees: University of Kansas, Rutgers, The State University of New Jersey
    Inventors: Rita Colella, John W. C. Bird, Hideaki Nagase
  • cDNA clones encoding chicken egg white cystatin
    Patent number: 5124443
    Abstract: cDNA clones coding for the chicken Cysteine proteinase inhibitor cystatin were found and isolated using for example a synthetic oligonucleotide probe corresponding to amino acids 81-90 of the cystatin sequence. This was used to screen a lambda gt 11 chicken oviduct cDNA library. A full length cystatin cDNA was also isolated.
    Type: Grant
    Filed: May 16, 1989
    Date of Patent: June 23, 1992
    Assignees: University of Kansas, Rutgers, The State University of New Jersey
    Inventors: Rita Colella, John W. C. Bird, Hideaki Nagase