Abstract: There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening.

Abstract: It is intended to provide a sensor chip which has a small size and is easily produced and capable of determining quantities of at least two components of multiple samples rapidly, conveniently, and correctly as well as to provide a production method capable of producing the sensor chip easily and with high productivity. A sensor chip includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, multiple reaction portions disposed between the substrate and the cover layer, multiple detection units exposed in the hollow reaction portions, and a sample inlet communicated with the hollow reaction portions and a method for producing the sensor chip.

Abstract: An object of present invention is to provide a process of producing bisphenol A, and more particularly a process of producing bisphenol A having high purity and an excellent hue. In the present invention, in a crystallization step to form the slurry containing adduct crystals, (a) a fed solution of bisphenol A in phenol is cooled at the temperatures of at least two steps to form a slurry containing adduct crystals, (b) at least two crystallization stages having different cooling temperatures are provided, and (c) when the solid fraction of the slurry is A [% by weight] in the final crystallization stage prior to transporting the slurry into the solid-liquid separation step and the solid fraction of the slurry is B [% by weight] in the crystallization stage in which crystals are first formed, the value of B/A is kept 0.7 or less.

Abstract: Provided are a biosensor chip measurement machine that can obtain accurate measurement results within a short period of time by employing only a tiny amount as a sample, and a measurement method therefor. A biosensor measurement machine 20 includes a power source 21, which is connected to a voltage regulator 22, a measurement instrument 23, and a controller 24 for supplying power. When a biosensor chip 1 is connected to the biosensor measurement machine 20 and a voltage is applied, the measurement instrument begins the measurement of a current value for a biosensor. When a measured current value or a measured charge value is greater than a reference value, the measurement is ended in accordance with an instruction issued by the controller 24, and when the value is smaller than the reference value, the measurement is continued in accordance with a controller instruction.

Abstract: It is intended to provide a sensor chip that enables detection of a deterioration state of a reagent applied on a reaction portion when measuring a concentration of a measurement object substance and a sensor system that enables a correct measurement by using the sensor chip for detecting the reagent deterioration state. A sensor chip including two substrates opposed to each other, a spacer layer sandwiched between the substrates, a multiple reaction portions provided in the spacer layer, and detection electrode units disposed on surfaces of the substrates facing to the spacer layer and exposed to the reaction portions, wherein an identical reagent A is applied on two or more of the reaction portions, and another reagent B that reacts with the reagent A is applied on at least one of the two reaction portions and a sensor system including the sensor chip and a measurement unit for comparing current values from the two or more reaction portions on which the identical reagent A is applied.

Abstract: There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein the puncture needle is able to be kept hygienic without the need of a protective cover or the like for the puncture needle. There is a needle integrated biosensor, including: a biosensor including at least two electrodes, and a puncture needle to collect a body fluid by piercing a skin of a person to be tested, the biosensor and the puncture needle being integrated, wherein a soft material is attached to the front end of the puncture needle so that the front end of the puncture needle is protected.

Abstract: There is provided a biosensor (which is integrated with a needle) with a high precision where an assembling is easy and reproducibility of the prepared biosensor (integrated with a needle) is good. There is provided with a biosensor comprising: two sheets of electrically insulating substrates connected by a connecting part, and an electrode and a spacer formed on one of or both of the two sheets of electrically insulating substrates, wherein the two sheets of the electrically insulating substrates are folded along the connecting part, and the electrode and the spacer are positioned between the electrically insulating substrates.

Abstract: There is provided a sensor chip including: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer, in which a reaction is performed between a sample and a reagent applied thereinto; a sensing member constructed of an electrode which is exposed to the hollow reaction portion; and a sample inlet for conducting the sample to the hollow reaction portion, wherein entire portions of the base plate and the cover layer, which are located opposite to the sensing member provided with the hollow reaction portion, are made transparent.

Abstract: A method for fabricating a sensor chip having a substrate, a cover layer, a spacer layer interposed between the substrate and the cover layer, and a hollow reaction section provided in the spacer layer, the method comprising the steps of: affixing two or more adhesive or bonding tapes onto a sheet where a plurality of substrates are to be formed or onto a plurality of substrates, to thus form a spacer layer; and forming a hollow reaction section from one or a plurality of gaps between the tapes, whereby volumetric variations or positional displacements of the hollow reaction section can be reduced. A sensor chip which can be fabricated by this method.

Abstract: It is intended to provide a biosensor chip capable of rapid and correct measurement, including a reaction chamber that enables a measurement of a very small amount of a measurement sample and has a small capacity and potassium ferricyanide having a very small crystal particle size disposed in the reaction chamber. In a biosensor chip 1, electrodes 3 and 4 are disposed on the lower substrate 2, and lower spacer 5 (7 and 8) is adhered on the electrodes 3 and 4. An upper spacer 11 (12 and 13) is adhered to an upper substrate 15, and a lower spacer 5 is attached to the upper spacer 11 by and adhesive agent 10. A lower groove 9 is formed between long and short lower spacers 7 and 8, and an upper groove 14 is formed between long and short spacers 12 and 13, so that a reaction chamber 17 is formed by the upper and lower grooves 9 and 14. A capacity of the reaction chamber is 0.

Abstract: A valve timing control apparatus is adapted to an exhaust valve side of an internal combustion engine. A vane member is arranged to rotate with a camshaft relative to a timing sprocket member. The vane member is rotated at low speed engine operation dominantly by a camshaft-torque actuation mechanism and at high speed engine operation dominantly by a hydraulic actuation mechanism. The camshaft-torque actuation mechanism is actuated by an alternating torque of the camshaft, whereas the hydraulic actuation mechanism is actuated by a fluid pump. The vane member includes a first vane arranged to operate in the camshaft-torque actuation mechanism and a second vane arranged to operate in the hydraulic actuation mechanism. The first vane has a shorter radial length and a smaller pressure-receiving area than the second vane.

Abstract: Provided are a sensor chip and a manufacturing method of this sensor chip, that includes a substrate, a cover layer, a spacer layer sandwiched between the substrate and the cover layer, and a hollow reaction section between the substrate and the cover layer, wherein warping due to changes in the environmental temperature and humidity does not occur. A sensor chip is provided including: a substrate; a cover layer; a spacer layer sandwiched between the substrate and the cover layer; a hollow reaction section provided between the substrate and the cover layer; and a detection section provided in the hollow reaction section, wherein the substrate and the cover layer are made of the same material and have the same thickness, and a material and a shape of the spacer layer are symmetrical with respect to a plane which is parallel to the substrate and located at equal distances from the substrate and from the cover layer, and a manufacturing method of the sensor chip is provided.

Abstract: There is provided a biosensor unified with a needle in which, since its constitution is simple, its assembling is easy in spite of having strength, collecting of body fluid sample can be conducted surely without waste, a puncturing needle is not polluted by a reagent layer, carrying is easy due to its simple package and hygiene can be maintained even after use. There is also provided a biosensor unified with a needle in which an assembling is easy without deteriorating its strength and collecting a body fluid sample can be surely conducted without waste where a puncturing needle is not polluted with a reagent layer.

Abstract: A coupled member made of a plurality of sensor chips is featured by that adjacent sensor chips are coupled to each other under cuttable condition; the respective sensor chips can be cut and piece-separated from the coupled member in a higher efficiency; and even after the sensor chips are piece-separated, these sensor chips can be readily and quickly stored in containers thereof; and furthermore, the sensor chips can be easily checked and failure chips can be readily removed.

Abstract: There is provided a modified ion exchange resin catalyst which exhibits higher bisphenols selectivity than the conventional modified ion exchange resins in processes wherein bisphenols are produced by reacting a phenolic compound with ketones, and to provide such a process for producing bisphenols.

Abstract: A polypeptide absorbable into digestive organs, which is linked with a bioactive polypeptide, and assists absorption of the bioactive polypeptide into digestive organs when it is orally taken; a fusion polypeptide comprising the polypeptide absorbable into digestive organs and the bioactive polypeptide; and an oral composition comprising the fusion polypeptide are provided.

Abstract: A valve timing control apparatus is adapted to an exhaust valve side of an internal combustion engine. A vane member is arranged to rotate with a camshaft relative to a timing sprocket member. The vane member is rotated at low speed engine operation dominantly by a camshaft-torque actuation mechanism and at high speed engine operation dominantly by a hydraulic actuation mechanism. The camshaft-torque actuation mechanism is actuated by an alternating torque of the camshaft, whereas the hydraulic actuation mechanism is actuated by a fluid pump. The vane member includes a first vane arranged to operate in the camshaft-torque actuation mechanism and a second vane arranged to operate in the hydraulic actuation mechanism. The first vane has a shorter radial length and a smaller pressure-receiving area than the second vane.

Abstract: A downsized biosensor in which an electrode is formed on one sheet of electrically-insulated substrate, and a sheet of flat substrate is worked three-dimensionally so as to dispose the electrode on the inner side of the substrate to provide a two-dimensional or three-dimensional electrode disposition, whereby a sample introduced by capillary phenomenon can be measured quantitatively in a small space. A production method of a biosensor comprising the steps of bending a plate member so as to position an electrode formed on the surface of the electrically-insulated plane member on the inner side, and disposing the electrode in a space surrounded by a substrate and a cover to thereby form the substrate and the cover from one sheet of plate member.