Abstract: The present invention provides a method for evaluating the pharmacological action of HGF that utilizes a PD marker in which fluctuation is recognized by administration of hepatocyte growth factor (HGF) in a broader range of subjects. A method for evaluating the pharmacodynamic action of HGF is provided. The aforementioned evaluation method is characterized in that it comprises a step of measuring the ApoA4 level in a biological sample collected from a test subject who was administered HGF. According to the present invention, a kit for evaluating the pharmacodynamic action of HGF comprising an anti-ApoA4 antibody is further provided.

Abstract: A vehicle including an internal combustion engine and a stepped transmission including an input shaft and an output shaft, wherein the stepped transmission speed-changes power input to the input shaft while changing a shift speed and outputs the speed-changed power to the stepped transmission output shaft; a control unit that controls the engine and the stepped transmission in accordance with an output request from an operator. The vehicle also including input and output shaft rotation speed detecting units and an output limiting unit that limits the output of the engine by comparing the deviation of the input and output shaft rotation speed to a predetermined rotation speed relationship range. The vehicle also including an abnormality determining unit to determine that an abnormality has occurred in the stepped transmission when the rotation speed relationship exceeds the range of the predetermined rotation speed relationship for at least a first predetermined time period.

Abstract: A control device for an automatic transmission capable of operating in an automatic shift mode in which a gear ratio is automatically selected based on driving conditions of a vehicle, and also capable of operating in a manual shift mode in which the gear ratio is changed based on an upshift command or a downshift command by manual operation of a manual operation device, the control device includes a manual shift control unit that changes and sets the gear ratio after downshift depending on a degree of requirement for deceleration based on a driving operation when the downshift command has been operated by the manual operation device in the manual shift mode, and performs the downshift to the gear ratio that has been changed and set.

Abstract: A control system for an automatic transmission is provided with a manual shift mode capable of performing a shift command made by manual operation. While in the manual shift mode and during the operation of a downshift command generated by a shift lever, a manual shift control unit calculates a degree of power required by a driver that, for example, takes into consideration an operation intent of the driver and a road condition. A post-downshift shift speed is then determined in accordance with the degree of required power and downshifting performed. By performing only one downshift command through manual operation, downshifting in accordance with the degree of power required by the driver is performed. Downshifting to a shift speed desired by the driver can thus be promptly performed, without the operation becoming a burden.

Abstract: A control apparatus for an automatic transmission capable of operating in an automatic shift mode in which a speed ratio is automatically selected based on driving conditions of a vehicle, and a manual shift mode in which the speed ratio is changed based on an upshift command and a downshift command by manual operation of a manual operation unit, the control apparatus includes a controller that operates in a jumping shift mode that is included in the manual shift mode and that is composed of a smaller number of shift speeds than a number of shift speeds of the automatic shift mode; wherein the controller performs a downshift from a shift speed of the jumping shift mode at a time when the downshift command is issued by an operation of the manual operation unit based on the shift speed of the jumping shift mode.

Abstract: A control device for an automatic transmission capable of operating in an automatic shift mode in which a gear ratio is automatically selected based on driving conditions of a vehicle, and also capable of operating in a manual shift mode in which the gear ratio is changed based on an upshift command or a downshift command by manual operation of a manual operation device, the control device includes a manual shift control unit that changes and sets the gear ratio after downshift depending on road conditions when the downshift command has been operated by the manual operation device in the manual shift mode, and performs the downshift to the gear ratio that has been changed and set.

Abstract: An object of the present invention is to provide a T cell adhesion molecule that is expressed on a dendritic cell. According to the present invention, there is provided a protein comprising the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10 or SEQ ID NO: 12.

Abstract: A control system for an automatic transmission is provided with a manual shift mode capable of performing a shift command made by manual operation. While in the manual shift mode and during the operation of a downshift command generated by a shift lever, a manual shift control unit calculates a degree of power required by a driver that, for example, takes into consideration an operation intent of the driver and a road condition. A post-downshift shift speed is then determined in accordance with the degree of required power and downshifting performed. By performing only one downshift command through manual operation, downshifting in accordance with the degree of power required by the driver is performed. Downshifting to a shift speed desired by the driver can thus be promptly performed, without the operation becoming a burden.

Abstract: A control device for an automatic transmission capable of operating in an automatic shift mode in which a gear ratio is automatically selected based on driving conditions of a vehicle, and also capable of operating in a manual shift mode in which the gear ratio is changed based on an upshift command or a downshift command by manual operation of a manual operation device, the control device includes a manual shift control unit that changes and sets the gear ratio after downshift depending on a degree of requirement for deceleration based on a driving operation when the downshift command has been operated by the manual operation device in the manual shift mode, and performs the downshift to the gear ratio that has been changed and set.

Abstract: A control apparatus for an automatic transmission capable of operating in an automatic shift mode in which a speed ratio is automatically selected based on driving conditions of a vehicle, and a manual shift mode in which the speed ratio is changed based on an upshift command and a downshift command by manual operation of a manual operation unit, the control apparatus includes a controller that operates in a jumping shift mode that is included in the manual shift mode and that is composed of a smaller number of shift speeds than a number of shift speeds of the automatic shift mode; wherein the controller performs a downshift from a shift speed of the jumping shift mode at a time when the downshift command is issued by an operation of the manual operation unit based on the shift speed of the jumping shift mode.

Abstract: A control device for an automatic transmission capable of operating in an automatic shift mode in which a gear ratio is automatically selected based on driving conditions of a vehicle, and also capable of operating in a manual shift mode in which the gear ratio is changed based on an upshift command or a downshift command by manual operation of a manual operation device, the control device includes a manual shift control unit that changes and sets the gear ratio after downshift depending on road conditions when the downshift command has been operated by the manual operation device in the manual shift mode, and performs the downshift to the gear ratio that has been changed and set.

Abstract: A vehicle including an internal combustion engine and a stepped transmission including an input shaft and an output shaft, wherein the stepped transmission speed-changes power input to the input shaft while changing a shift speed and outputs the speed-changed power to the stepped transmission output shaft; a control unit that controls the engine and the stepped transmission in accordance with an output request from an operator. The vehicle also including input and output shaft rotation speed detecting units and an output limiting unit that limits the output of the engine by comparing the deviation of the input and output shaft rotation speed to a predetermined rotation speed relationship range. The vehicle also including an abnormality determining unit to determine that an abnormality has occurred in the stepped transmission when the rotation speed relationship exceeds the range of the predetermined rotation speed relationship for at least a first predetermined time period.

Abstract: A shift control apparatus of an automatic transmission of a motor vehicle to which torque is transmitted from an engine via a fluid coupling device is provided. In the automatic transmission including a plurality of hydraulically operated friction elements, a clutch-to-clutch downshift is carried out during coasting of the vehicle by releasing one of the friction elements and engaging another friction element. A controller of the shift control apparatus detects a difference between input and output rotation speeds of the fluid coupling device, and increases an engine speed by a controlled amount based on the difference between the input and output rotation speeds when the clutch-to-clutch downshift is carried out during coasting of the vehicle, so that the vehicle is brought into a minimal driving state in which the engine speed is slightly higher than the output rotation speed of the fluid coupling device.

Abstract: A duty ratio for controlling an engagement force of a friction engagement device on the side of upshift engagement is corrected by an amount corresponding to an intermediate correction control value in the course of the shift. In addition, on a prerequisite condition that learning correction of a constant standby pressure control value at the start of the shift is converged, learning correction is performed for the intermediate correction control value according to a gradient of a turbine speed. Thus, a shift shock is prevented from occurring due to abrupt engagement of the friction engagement device and the like at the completion of the shift.

Abstract: A shift control apparatus of an automatic transmission of a motor vehicle to which torque is transmitted from an engine via a fluid coupling device is provided. In the automatic transmission including a plurality of hydraulically operated friction elements, a clutch-to-clutch downshift is carried out during coasting of the vehicle by releasing one of the friction elements and engaging another friction element. A controller of the shift control apparatus detects a difference between input and output rotation speeds of the fluid coupling device, and increases an engine speed by a controlled amount based on the difference between the input and output rotation speeds when the clutch-to-clutch downshift is carried out during coasting of the vehicle, so that the vehicle is brought into a minimal driving state in which the engine speed is slightly higher than the output rotation speed of the fluid coupling device.

Abstract: To prevent the neutral state from being formed in a change gear apparatus and allow the obtaining of an intended gear change appropriately during a servo malfunction. Hydraulic servos engage and disengage a plurality of friction engagement elements; a hydraulic pressure supply system supplies the hydraulic servo of a predetermined friction engagement element with hydraulic pressure; and an auxiliary hydraulic pressure supply systems supplies a predetermined hydraulic servo with another hydraulic pressure, in the case where the hydraulic pressure supply system is placed in a first unsupplied state where the hydraulic pressure supply system cannot supply the hydraulic servo of the predetermined friction engagement element with hydraulic pressure.

Abstract: Apparatus for controlling a vehicle drive system including a drive power source, a fluid-operated power transmitting device connected to the drive power source, and an automatic transmission for transmitting a rotary motion of the fluid-operated power transmitting device to vehicle drive wheels such that a speed ratio of the automatic transmission is variable, the apparatus being arranged to increase an output of the drive power source for increasing its speed upon a shift-down action of the automatic transmission so as to increase its speed ratio during a coasting run of the vehicle, and including an output controlling element operable to control the output of the drive power source, and a gradually output increasing device operable upon the shift-down action during the coasting run, for controlling the output controlling element so as to gradually increase the speed of the drive power source at a predetermined rate.

Abstract: A shift control apparatus of an automatic transmission of a motor vehicle to which torque is transmitted from an engine via a fluid coupling device is provided. In the automatic transmission including a plurality of hydraulically operated friction elements, a clutch-to-clutch downshift is carried out during coasting of the vehicle by releasing one of the friction elements and engaging another friction element. A controller of the shift control apparatus detects a difference between input and output rotation speeds of the fluid coupling device, and increases an engine speed by a controlled amount based on the difference between the input and output rotation speeds when the clutch-to-clutch downshift is carried out during coasting of the vehicle, so that the vehicle is brought into a minimal driving state in which the engine speed is slightly higher than the output rotation speed of the fluid coupling device.

Abstract: Apparatus for controlling a vehicle drive system including an automatic transmission, including a feedback controller operable upon a shift-down action of the transmission effected by concurrent releasing and engaging actions of first and second frictional coupling devices during an operation of a manually operable vehicle accelerating member to drive the vehicle with the drive power soruce, for controlling an engaging force of the first frictional coupling device, and a learning compensator operable upon detection of an abnormality of the shift-down action, for learning compensation of an initial value of the engaging force at which a feedback control of the engaging force is initiated, or an output reducing device for reducing an output of a drive power source when input speed of the transmission has been increased to a value close to a synchronization value, and/or upon racing of the drive power source during the shift-down action.

Abstract: Apparatus for controlling a vehicle automatic transmission having a hydraulically operated frictional coupling device operable to effect a shifting action of the automatic transmission, a switching valve operable according to a shifting command to effect the shifting action, and a pressure regulating valve operable to control a pressure of a working fluid to be supplied to the frictional coupling device through the switching valve to effect the shifting action, the apparatus including (a) a fluid temperature detector operable to detect a temperature of the working fluid, and (b) a delaying device operable to delay a moment of initiation of an operation of the pressure regulating valve to control the pressure of the working fluid to be supplied to the frictional coupling device for effecting the shifting action, such that the moment of initiation is delayed depending upon the detected working fluid temperature, to reduce a shifting shock of the automatic transmission.