Abstract: A target value for a gap between a developer bearing member supported by a developing frame member and a regulating blade that is fixed to the developing frame member is determined based on input information about a local maximum peak value of magnetic flux density of a predetermined magnetic pole which is located closest to the regulating blade when the regulating blade is fixed to the developing frame member among a plurality of magnetic poles included in a magnet fixedly located inside the developer bearing member and configured to generate a magnetic field for causing a developer to be borne by the developer bearing member.

Abstract: Provided are: an acquisition unit that acquires physical state information indicating physical states of the people from one or more sensors that detect at least the people; a physical function analysis unit that analyzes a change in physical functions of the people based on a time-series change of the physical state information acquired by the acquisition unit; and a physical function improvement proposing unit that generates and outputs physical function improvement proposal information indicating an improvement proposal of the physical function with respect to the change in the physical functions of the people based on an analysis result of the physical function analysis unit.

Abstract: A highly reliable horizontal rotary compressor is provided with a sealed housing, an electric motor, a compression mechanism, a frame which divides the inside of the sealed housing into an electric-motor chamber and a compression-mechanism chamber, and a plurality of bolts that fasten the compression mechanism to the frame. The compression mechanism includes a main bearing fasten to the end surface of a cylinder. A bearing contact-surface of the end surface of the cylinder is in contact with the main bearing, is located closer to the electric motor than a frame contact-surface which is in contact with the frame. The surface roughness of the frame contact-surface is greater than the surface roughness of the bearing contact-surface. The contact-surface of the frame is a single continuous flat surface located above the bolt located at the lowest position among the plurality of bolts.

Abstract: Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.

Abstract: A diagnosis model component reuse support apparatus includes a case characteristic storage part, a diagnosis model storage part, a diagnosis module storage part, and an operational device that supports reuse of a diagnosis model component of a past diagnosis case when a diagnosis model for a new diagnosis case is constructed. The operational device includes a reusability calculator that, by using case characteristics in the case characteristic storage part, a diagnosis model in the diagnosis model storage part, and diagnosis modules in the diagnosis module storage part, calculates, for each of the case characteristics, the reusability of each of the diagnosis modules or the reusability of a coupling relationship of the diagnosis modules, and extracts a diagnosis module or a coupling relationship having high reusability as a diagnosis model component. The operational device also includes a coupling relationship extension part that adds another diagnosis module to the diagnosis model component.

Abstract: A medicament effective for prophylactic and/or therapeutic treatment of a peripheral neuropathic pain such as allodynia caused by a treatment with an anticancer agent, which comprises thrombomodulin as an active ingredient.

Abstract: The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27.

Abstract: This invention provides a method for detecting cognitive disfunction diseases including mild cognitive impairment and Alzheimer's disease using a protein and a peptide of the protein different in the presence level in subjects having a normal cognitive function and patients suffering from cognitive disfunction diseases and a biomarker for detecting cognitive disfunction diseases including mild cognitive impairment and Alzheimer's disease containing the protein and the peptide.

Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.

Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.

Abstract: To associate condition information, such as (a) a location in a movement section at which fatigue occurred, (b) a type of work or operation during which fatigue occurred, and (c) a type of natural phenomenon experienced when fatigue occurred, a device for displaying the material fatigue of a machine is configured to observe stress variation in a time series using a sensor correlated with the stress variation or stress of a machine. Stress variation in a single cycle and the time when the stress variation occurred are detected, and the stress variation value and time of occurrence are output and displayed.

Abstract: Methods are provided that detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence. Novel biomarkers are also provided for cognitive impairment and non-psychiatric disease, as well as methods for detecting cognitive impairment using such biomarkers. Specifically, a biomarker for diagnosis is provided that comprises a protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of an amino acid sequence expressed by SEQ ID NO: 1, 3, 6, 8, 10, 13, 15, 18, or 20 and selected from the group of partial peptide in these proteins consisting of an amino acid sequence expressed by SEQ ID NO: 2, 4, 5, 7, 9, 11, 12, 14, 16, 17, 19, or 21.

Abstract: A conveyance device includes: a holder to hold a paper roll and rotate along with rotation of the paper roll; a conveyor to convey a sheet located at an entry of a sheet conveyance path; a motor to apply a conveyance force to the conveyor; a first power supply circuit to output power both in a sleep mode and a ready mode; a second power supply circuit to output power in the ready mode but not in the sleep mode; a signal output unit supplied with the power from the first power supply circuit and to output a rotation detection signal when the holder rotates in the sleep mode or the ready mode; and a controller to, when the rotation detection signal is received in the sleep mode, turn on the second power supply circuit to supply the power to at least the motor to convey the sheet.

Abstract: A developing apparatus includes a developer carrier configured to carry developer, a developer container having a first chamber and a second chamber, a first conveying member provided in the first chamber, and including a first conveying unit and, on a downstream side in a first direction, a reverse conveying unit, a second conveying member, a discharge unit configured to discharge the developer, and a partition wall having a first communication port and a second communication port and configured to partition the first chamber and the second chamber. In addition, a plurality of protruding portions are provided so as to oppose the first conveying member at a position above a region between the first conveying unit and the reverse conveying unit in a vertical direction, each of the protruding portions extending along the first direction, wherein the plurality of protruding portions are arranged in a row in a direction orthogonal to the first direction.

Abstract: A maintenance management system includes: a failure information DB that stores at least a failure mode for each of diagnosis target assets; an automatic diagnosis definition DB that stores diagnostic criteria for diagnosing failure modes of the diagnosis target assets; an automatic diagnosis unit that detects or predicts occurrence of a failure mode of a diagnosis target asset, based on a measurement value representing a state of the diagnosis target asset measured by a sensor and the diagnostic criteria; a maintenance method DB that stores in advance a maintenance method corresponding to a failure mode; an automatic diagnosis result log storage unit that records at least a diagnosis result by the automatic diagnosis unit and information regarding an alarm issued; and a maintenance work log storage unit that records at least a maintenance work content performed on the diagnosis target asset and includes a task performance analysis unit.

Abstract: A robot system includes a fixed camera that obtains first measurement data by detecting a plurality of features positioned within a detection range, the detection range including at least part of a range in which a robot arm is movable, a hand camera movable with the robot arm, and a control apparatus that controls the robot arm. A calibration function that relates a value obtained as part of the first measurement data to a command value provided to the robot arm at each of a plurality of positions and orientations at which the hand camera obtains second measurement data by detecting each mark.

Abstract: An analysis device for time series data from an apparatus to be diagnosed is provided with an accumulation device which accumulates sensor data, operation data, or control data, obtained from the apparatus, while accumulating time information, an algorithm accumulation unit which accumulates algorithms for recognizing behavior of the apparatus, a behavior recognition unit which recognizes behavior of the apparatus by using a recognition algorithm, and a specification unit which specifies a behavioral item to be recognized. A behavior recognition algorithm corresponding to the specified behavioral item is selected from the algorithm accumulation unit; sensor data, operation data, or control data is selected from the accumulation device; start and end times of a selected behavior are recognized by the behavior recognition unit; and the recognized start and end times are associated with time information about data accumulated in the accumulation device.

Abstract: A sealing structure includes a main body, a lid that seals an opening of the main body, a slide unit provided in the lid and slidable along the main body, and a plurality of protrusions provided along the sliding direction of the slide unit at the opening of the main body. The slide unit includes a plurality of lock levers provided to correspond to the plurality of protrusions, and claws that engage with the plurality of protrusions at the time when the slide unit slides in a predetermined direction.

Abstract: A target value for a gap between a developer bearing member supported by a developing frame member and a regulating blade that is fixed to the developing frame member is determined based on input information about a local maximum peak value of magnetic flux density of a predetermined magnetic pole which is located closest to the regulating blade when the regulating blade is fixed to the developing frame member among a plurality of magnetic poles included in a magnet fixedly located inside the developer bearing member and configured to generate a magnetic field for causing a developer to be borne by the developer bearing member.

Abstract: A polyamide resin composition includes: 100 parts by mass of (A) a polyamide having a melting point of 280 to 330° C.; 0.5 to 80 parts by mass of (B) aluminum diethylphosphinate; 0.2 to 2 parts by mass of (C) at least one phosphorous acid ester represented by formula (6) or (7); and (E) at least one reinforcing material. A mass ratio of the at least one phosphinic acid salt (B) to the at least one phosphorous acid ester (C) ((B)/(C)) is in a range of from 10 to 100. An average particle diameter of the phosphinic acid salt (B) is 0.1 to 100 ?m. The polyamide resin composition does not comprise a metallic soap-based lubricant.