Abstract: A new human polypeptide, a cDNA encoding the same and a pharmaceutical use of it.

Abstract: A polypeptide comprising 295 amino acids which is produced by mouse bone marrow stromal cells, a method of producing the polypeptide, a DNA encoding the polypeptide, a fragment which selectively hybridized the DNA sequence, a replication or expression vector comprising the DNA, a host cell transfected with the vector, an antibody of the peptide, a pharmaceutical composition containing the polypeptide or the antibody.

Abstract: A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.

Abstract: A polypeptide prepared from mouse ES cell strains by the SST method and a homologous polypeptide obtained from mouse kidney, human uterus, mouse fetus, human fetal liver and pancreas libraries; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an antibody against the polypeptide; and a pharmaceutical composition containing the polypeptide or the antibody.

Abstract: The polypeptides of the present invention are produced and secreted in pro-B cells, so they may be used for diseases relating to undergrown or abnormal proliferation of hematopoietic cells, neuronal enhancement or depression, immunological enhancement and depression, for example, inflammatory diseases (rheumatoid arthritis, ulcerative colitis etc.), hematopoietic stemcytopenia after bone marrow transplantation, leukocytopenia, thrombocytopenia, B lymphopenia and T lymphopenia after chemotherapy, anemia, infectious diseases, cancer, leukocytosis, AIDS, neurodegenerative diseases (Alzheimer, multiple sclerosis etc.), prevention of treatment of neuronal injury, prevention of treatment of disorder of bone metabolism (osteoporosis etc.) or tissue repair. The DNA of the present invention may be utilized as an important and essential template in preparing the polypeptides of the present invention which are expected to possess various use or for diagnosis of an in the treatment of gene diseases.

Abstract: The Stromal Derived Factor-1.alpha. (SDF-1.alpha.) and Stromal Derived Factor-1.beta. (SDF-1.beta.) polypeptides of the present invention are produced and secreted in pro-B cells, so they may be used for diseases relating to undergrown or abnormal proliferation of hematopoietic cells, neuronal enhancement or depression, immunological enhancement and depression, for example, inflammatory diseases (rheumatoid arthritis, ulcerative colitis etc.), hematopoietic stemcytopenia after bone marrow transplantation, leukocytopenia, thrombocytopenia, B lymphopenia and T lymphopenia after chemotherapy, anemia, infectious diseases, cancer, leukocytosis, AIDS, neurodegenerative diseases (Alzheimer, multiple sclerosis etc.), prevention or treatment of neuronal injury, prevention or treatment of disorder of bone metabolism (osteoporosis etc.) or tissue repair.

Abstract: The present invention relates to (1) a process for constructing a cDNA library which has a selectivity for signal peptides, that makes it possible to efficiently find out an unknown and useful polypeptide and a high efficiency; and relates to (2) a novel polypeptide consisting of 89 amino acids (including a signal peptide) produced by a stroma cell line, which is useful as an agent for preventing or treating, for example, anemia, leukopenia or infections and the like, and DNAs encoding for said polypeptide.

Abstract: A display signal generator device which allows the pulse width of a digital signal to be constant and the pulse repetition period to be proportional to the analog amount of an input signal so as to produce a signal to be displayed even by an analog or digital display unit 7 or 6, thereby obtaining a digital/analog common signal of average value proportional to the frequency even with the pulse signal. In order to maintain the pulse width constant, only a monostable multivibrator is, for example, added, thereby providing an inexpensive display signal generator device.

Abstract: An inverter controlling method comprising corresponding DC bus voltage after power inversion relating to commercial power supply voltage, and in a comparator, comparing both voltages, detecting the DC bus voltage at the time point when the both voltages are the same to discriminate and store the level of the commercial AC power supply voltage, and making correction of the output voltage at the next operational start of the inverter on the basis of the stored information.

Abstract: A boron-treated steel comprises a carbon steel, or a low alloy steel containing 0.15 to 0.85% C, 0.15 to 2.0% Si, 0.3 to 1.5% Mn, not more than 1.0% Cr, not more than 0.020% of P and S each, and unavoidable quantities of Al and Ti not exceeding 0.008% and 0.010%, respectively, and further contains 6 to 30 ppm of acid-soluble boron. The steel produced is less likely to develop cracks and can be produced at substantially reduced costs.