Patents by Inventor Hideaki Tokai

Hideaki Tokai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing optically active succinimide derivatives and intermediates thereof
    Patent number: 9434737
    Abstract: Provided is a process for producing (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1?H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone (compound A). The method includes converting an optically active succinimide derivative of formula (I) to compound A, in which the compound of formula (I) has been prepared by reacting a base with an optically active amide derivative of formula (VI).
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: September 6, 2016
    Assignees: Sumitomo Dainippon Pharma Co., Ltd., Kyowa Hakko Bio Co., Ltd.
    Inventors: Masaji Kasai, Shinji Kita, Tadashi Ogawa, Hideaki Tokai
  • PROCESS FOR PRODUCING OPTICALLY ACTIVE SUCCINIMIDE DERIVATIVES AND INTERMEDIATES THEREOF
    Publication number: 20140099681
    Abstract: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1?H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps.
    Type: Application
    Filed: December 12, 2013
    Publication date: April 10, 2014
    Applicants: Kyowa Hakko Bio Co., Ltd., Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Masaji KASAI, Shinji KITA, Tadashi OGAWA, Hideaki TOKAI
  • Process for producing optically active succinimide derivatives and intermediates thereof
    Patent number: 8633001
    Abstract: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1?H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: January 21, 2014
    Assignees: Dainippon Sumitomo Pharma Co., Ltd., Kyowa Hakko Bio Co., Ltd.
    Inventors: Masaji Kasai, Shinji Kita, Tadashi Ogawa, Hideaki Tokai
  • PROCESS FOR PRODUCING OPTICALLY ACTIVE SUCCINIMIDE DERIVATIVES AND INTERMEDIATES THEREOF
    Publication number: 20120034660
    Abstract: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2?-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4?(1H)-pyrrolo[1,2-a]pyrazine}-1?,2,3?,5(2?H)-tetraone, which comprises the following reaction steps.
    Type: Application
    Filed: February 5, 2010
    Publication date: February 9, 2012
    Applicants: KYOWA HAKKO BIO CO., LTD., DAINIPPON SUMITOMO PHARMA CO., LTD.
    Inventors: Masaji Kasai, Shinji Kita, Tadashi Ogawa, Hideaki Tokai