Abstract: A bypass line (35) having one end side connected to a pilot delivery line (23) between a pilot pump (16) and a throttle (32) and the other end side connected to the pilot delivery line (23) between a check valve (33) and a pressure reducing valve type pilot valve (25) so as to bypass the throttle (32), a gate lock valve (27), and the check valve (33) provided in order from a pilot pump (16) is provided in the pilot delivery line (23). A lock switching valve (36) shutting down a flow of a pilot pressure oil from the pilot pump (16) through the bypass line (35) at a normal time and allowing the flow of the pilot pressure oil through the bypass line (35) when a pressure generated in the pilot delivery line (23) exceeds a predetermined pressure between the gate lock valve (27) and the check valve (33) is provided in the bypass line (35).

Abstract: A bypass line (35) having one end side connected to a pilot delivery line (23) between a pilot pump (16) and a throttle (32) and the other end side connected to the pilot delivery line (23) between a check valve (33) and a pressure reducing valve type pilot valve (25) so as to bypass the throttle (32), a gate lock valve (27), and the check valve (33) provided in order from a pilot pump (16) is provided in the pilot delivery line (23). A lock switching valve (36) shutting down a flow of a pilot pressure oil from the pilot pump (16) through the bypass line (35) at a normal time and allowing the flow of the pilot pressure oil through the bypass line (35) when a pressure generated in the pilot delivery line (23) exceeds a predetermined pressure between the gate lock valve (27) and the check valve (33) is provided in the bypass line (35).

Abstract: A working mechanism (4) takes a traveling stance by a way that left and right boom cylinders (9, 10) are expanded to rotate a tip end of a first boom (5) to the rear side and a positioning cylinder (11) is compressed to rotate a tip end of a second boom (6) to the lower side. In the traveling stance of the working mechanism (4), a front surface plate (23A) of a right front housing cover (23) is inclined along a tilting angle (?) of the left and right boom cylinders (9, 10), and the front surface plate (23A) of the right front housing cover (23) is arranged in a position of lining with front ends (9A1, 10A1) of tubes (9A, 10A) in the left-right direction forming the respective boom cylinders (9, 10).

Abstract: A right front housing cover is arranged in the right side of a working mechanism, and a first control valve is arranged in a front portion side of a valve accommodation room that is covered with the right front housing cover. Further, a signal control valve block is arranged in the back side of the first control valve and in the upper side of the first control valve, and a solenoid valve is arranged in the back side of the signal control valve block. A front surface plate forming part of the right front housing cover has a lower side is inclined in an oblique downward direction toward the forward side, and is arranged along a virtual line that extends in an oblique downward direction through a front end portion of the first control valve and a front end portion of the signal control valve block.

Abstract: A right front housing cover is arranged in the right side of a working mechanism, and a first control valve is arranged in a front portion side of a valve accommodation room that is covered with the right front housing cover. Further, a signal control valve block is arranged in the back side of the first control valve and in the upper side of the first control valve, and a solenoid valve is arranged in the back side of the signal control valve block. A front surface plate forming part of the right front housing cover has a lower side is inclined in an oblique downward direction toward the forward side, and is arranged along a virtual line that extends in an oblique downward direction through a front end portion of the first control valve and a front end portion of the signal control valve block.

Abstract: A working mechanism (4) takes a traveling stance by a way that left and right boom cylinders (9, 10) are expanded to rotate a tip end of a first boom (5) to the rear side and a positioning cylinder (11) is compressed to rotate a tip end of a second boom (6) to the lower side. In the traveling stance of the working mechanism (4), a front surface plate (23A) of a right front housing cover (23) is inclined along a tilting angle (?) of the left and right boom cylinders (9, 10), and the front surface plate (23A) of the right front housing cover (23) is arranged in a position of lining with front ends (9A1, 10A1) of tubes (9A, 10A) in the left-right direction forming the respective boom cylinders (9, 10).

Abstract: There is disclosed herein composition, methods and uses relating to miR-126 as a measure of engraftment potential of a population of hematopoietic stem cells (HSCs), as a method of purifying HSCs and in the monitoring or treatment of acute myeloid leukemia.

Abstract: A muffler draining apparatus for a working machine is provided which allows a drain line having excellent heat resistance to be reliably installed, even when a device or equipment is present at the position below a muffler. In a muffler draining apparatus that is provided to a muffler equipped to a hydraulic excavator, and includes a drain line that discharges water accumulated in the muffler to the outside of a vehicle body, the above-described drain line includes a single metal tubing whose one end is connected to the muffler, and whose intermediate portion provided continuous to the one end is extended into the space formed between the muffler and a hydraulic pump located below the muffler. The intermediate portion of the metal tubing includes a single linear portion and plural bent portions. Also, the muffler draining apparatus includes, for example, a single support bracket that is fixed to the muffler, and supports the intermediate portion of the metal tubing.