Abstract: Selective probes provide tandem activity-based sensing and labeling of reactive oxygen species (ROS), such as hydrogen peroxide, peroxynitrite, and organic peroxides.

Abstract: Disclosed is a pH-responsive fluorescent compound, represented by the general formula, which is a novel pH-responsive fluorescent compound capable of being specifically localized in mitochondria within cells, which exhibits strong fluorescence under weakly acidic pH environments in lysosomes, and which is not readily subject to interference from autofluorescence and background fluorescence due to other fluorescent substances within cells. Also disclosed are a composition for detecting mitophagy using the pH-responsive fluorescent compound, and a method for detecting mitophagy within cells. In the general formula, L represents a linker, X represents a pharmaceutically acceptable anion, and Y represents a reactive group that may react with a functional group on a mitochondrial protein to form a covalent bond.

Abstract: A fluorescent compound or a salt thereof represented by General Formulae (I) or (II) shown below: In the General Formulae (1) and (II) shown above, R1 and R11 represent an alkyl group or an ?-aminoalkyl group, R2 and R12 represent a hydrogen atom or a alkyl group, R3 and R13 represent an atomic group represented by a formula —(CH2)m— (m is a natural number of 10 or less), R4 and R14 represent an atomic group represented by a formula —CH2— or —NR6— (—NR16—) (R6 and R16 represent an alkyl group), R5 and R15 represent an atomic group represented by a formula —(CH2)n— (n is a natural number of or less), R represents an atomic group represented by any one of formulae —NH2, —NHR7—, NR7R8 and —NR7R8R9 (—NHR17, —NR17R18 and —N+R17R18R19) (R7, R8, R9, R17, R18 and R19 independently represents an alkyl group, respectively) and when R2 and R12 are alkyl groups and R4 (R14) is an atomic group represented by the formula —NR6—(—NR16—), R2 and R6 and R12 and R16 may bind with each other to form a ring.

Abstract: Disclosed is a pH-responsive fluorescent compound, represented by the general formula, which is a novel pH-responsive fluorescent compound capable of being specifically localized in mitochondria within cells, which exhibits strong fluorescence under weakly acidic pH environments in lysosomes, and which is not readily subject to interference from autofluorescence and background fluorescence due to other fluorescent substances within cells. Also disclosed are a composition for detecting mitophagy using the pH-responsive fluorescent compound, and a method for detecting mitophagy within cells. In the general formula, L represents a linker, X represents a pharmaceutically acceptable anion, and Y represents a reactive group that may react with a functional group on a mitochondrial protein to form a covalent bond.