Abstract: An artificial olfactory sensing system includes a sensor unit. The sensor unit includes a semiconductor device equipped with a transistor and a sensor cell in which an olfactory receptor is manifested on a lipid film. A proton adsorption film is formed on a gate electrode of the transistor. A physiological aqueous solution is disposed on the proton adsorption film. Then, the sensor cell is disposed in the physiological aqueous solution. A proton is adsorbed onto the proton adsorption film. When the olfactory receptor recognizes an odor molecule, the positive ions in the physiological aqueous solution flow from an ion channel of the olfactory receptor into the sensor cell. As a result, the proton is dissociated from the proton adsorption film into the physiological aqueous solution, and the potential of the gate electrode is changed.