Patents by Inventor Hidefumi Ozawa
Hidefumi Ozawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7919509Abstract: To provide a novel LXR? agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: February 27, 2009Date of Patent: April 5, 2011Assignee: Kowa Company, Ltd.Inventors: Ayumu Okuda, Takayuki Matsuda, Toru Miura, Hidefumi Ozawa, Ayako Tosaka, Koichi Yamazaki, Yuki Yamaguchi, Sayaka Kurobuchi, Yuichiro Watanabe, Kimiyuki Shibuya
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Publication number: 20090286780Abstract: To provide a novel LXR? agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: February 27, 2009Publication date: November 19, 2009Applicant: KOWA COMPANY, LTD.Inventors: Ayumu OKUDA, Takayuki MATSUDA, Toru MIURA, Hidefumi OZAWA, Ayako TOSAKA, Koichi YAMAZAKI, Yuki YAMAGUCHI, Sayaka KUROBUCHI, Yuuichirou WATANABE, Kimiyuki SHIBUYA
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Patent number: 7301033Abstract: The present invention provides a compound selectively activating PPAR?, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): wherein A represents an oxygen atom, a nitrogen atom, or a sulfur atom; R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkyl-alkyl group, an aryl group, an aryl-alkyl group an aryl-oxy-alkyl group, a pyridyl-alkyl group, an alkoxycarbonyl-alkyl group, or a carboxy-alkyl group; X represents an oxygen atom, an NH group, or an S(O)n group (wherein n represents an integer of 0, 1, or 2); and m represents an integer from 2 to 8; or a salt thereof. The present invention also provides a medicament comprising the benzoic acid derivative or the salt thereof as an active ingredient.Type: GrantFiled: January 20, 2006Date of Patent: November 27, 2007Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hajime Yamada, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe
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Patent number: 7183295Abstract: A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)l (l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosuType: GrantFiled: April 20, 2006Date of Patent: February 27, 2007Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Patent number: 7109226Abstract: A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR?.Type: GrantFiled: September 3, 2004Date of Patent: September 19, 2006Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Publication number: 20060189667Abstract: A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)l (l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosType: ApplicationFiled: April 20, 2006Publication date: August 24, 2006Applicant: KOWA CO., LTD.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Publication number: 20060167058Abstract: The present invention provides a compound selectively activating PPAR?, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): wherein A represents an oxygen atom, a nitrogen atom, or a sulfur atom; R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkyl-alkyl group, an aryl group, an aryl-alkyl group an aryl-oxy-alkyl group, a pyridyl-alkyl group, an alkoxycarbonyl-alkyl group, or a carboxy-alkyl group; X represents an oxygen atom, an NH group, or an S(O)n group (wherein n represents an integer of 0, 1, or 2); and m represents an integer from 2 to 8; or a salt thereof. The present invention also provides a medicament comprising the benzoic acid derivative or the salt thereof as an active ingredient.Type: ApplicationFiled: January 20, 2006Publication date: July 27, 2006Applicant: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hajime Yamada, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe
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Publication number: 20050101636Abstract: A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR?.Type: ApplicationFiled: September 3, 2004Publication date: May 12, 2005Applicant: KOWA CO., LTD.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Patent number: 6653334Abstract: The present invention is directed to a benzoxazole compound represented by the following formula (1): (wherein R1 represents an alkyl group, a C6-10 aryl-C1-8 alkyl group, etc.; each of R2 and R3, which are identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; and n represents a number of 1 to 3) or a salt thereof and to a pharmaceutical compound containing the same. These compounds electively activate PPAR&agr;.Type: GrantFiled: December 27, 2002Date of Patent: November 25, 2003Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe, Soichi Oda