Abstract: A relationship index value computation unit 100A that extracts n words from m texts representing contents of free conversations conducted by m patients whose severity of dementia is known, and computes a relationship index value reflecting a relationship between the m texts and the n words, a prediction model generation unit 14A that generates a prediction model for predicting severity of dementia based on a text index value group including n relationship index values for one text, and a dementia prediction unit 21A that predicts severity of dementia of a patient from a text subjected to prediction by applying the relationship index value computed by the relationship index value computation unit 100A from a text input by a prediction data input unit 20 to a prediction model are included, and severity of dementia can be predicted without performing a mini-mental state examination.

Abstract: Included are a learning data input unit 10 that inputs m texts included in the medical information of patient, a similarity index value computation unit 100 that extracts n words from m texts and computes a similarity index value reflecting a relationship between the m texts and the n words, a classification model generation unit 14 that generates a classification model for classifying m texts into a plurality of phenomena based on a text index value group including n similarity index values for one text, and an unsafe incident prediction unit 21 that predicts a possibility of occurrence of falling from a text to be predicted by applying a similarity index value computed by the similarity index value computation unit 100 from a text input by a prediction data input unit 20 to a classification model, and a highly accurate classification model is generated using a similarity index value that represents which word contributes to which text and to what extent.

Abstract: The present invention provides a diagnostic agent for endometriosis for measuring the concentration of at least one miRNA selected from the group consisting of hsa-miR-708, hsa-miR-127-3p and hsa-miR-518d-3p in a sample derived from the blood of a subject, the agent containing an amplification primer for the miRNA as a main component. The present invention also provides a method of detecting endometriosis, including a step of measuring the concentration of at least one miRNA selected, from the group consisting of hsa-miR-708, hsa-miR-127-3p and hsa-miR-518d-3p in a sample derived from the blood of the subject. The diagnostic agent for endometriosis of the present invention and the diagnostic method using the agent are simple and low invasive and have high sensitivity and specificity.

Abstract: The present invention provides a prophylactic or therapeutic drug for diabetes, which contains a polynucleotide such as miR-199b* and the like. Moreover, the present invention provides a method for screening for a prophylactic or therapeutic drug for diabetes, which includes measuring an expression level of a polynucleotide such as miR-199b* and the like. Furthermore, the present invention provides a method for determining the susceptibility to a prophylactic or therapeutic drug for diabetes, which includes measuring an expression level of a polynucleotide such as miR-199b* and the like.

Abstract: The present invention relates to novel benzodiazepine compounds exhibiting RXR-antagonist efficacy, to the manufacture and to the use thereof.

Abstract: The present invention relates to novel benzodiazepine compounds exhibiting RXR-antagonist efficacy, for delaying progression of, preventing or treating a condition or disease being associated with RXR-antagonism, in particular selected from diabetes, complication of diabetes such as retinopathy, nephropathy, neuropathy, and hyperlipidemia, obesity, dyslipidemia, and osteoporosis.

Abstract: The present invention relates to novel benzodiazepine compounds exhibiting RXR-antagonist efficacy, for delaying progression of, preventing or treating a condition or disease being associated with RXR-antagonism, in particular selected from diabetes, complication of diabetes such as retinopathy, nephropathy, neuropathy, and hyperlipidemia, obesity, dyslipidemia, and osteoporosis.