Abstract: The improved process for producing a signature panel comprises the steps of forming on the writing surface of a panel substrate a printed graphic pattern that will change upon exposure to alcohols, organic solvents, bleaching agents and surfactants, and laminating the other surface of the panel substrate with a thermoplastic resin by extrusion or hot melt coating. According to this process, signature panels can be thermocompressed at comparatively low temperatures not only to roll mills of overprint cards using a polyvinyl chloride sheet as an oversheet base but also to card substrates such as PET sheets, metal sheets and glass sheets without causing any adverse effects on the graphic pattern printed on the writing surface of the panel which will change upon exposure to chemicals.