Patents by Inventor Hidehito Tochio

Hidehito Tochio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer, contrast agent for nuclear magnetic resonance analysis or magnetic resonance imaging using the polymer, compound and method of nuclear magnetic resonance analysis and method of magnetic resonance imaging using the polymer
    Patent number: 10029021
    Abstract: As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of a 1H—13C—15N, 1H—15N—13C or 1H—13C—13C bond, that is, a structure labeled with stable isotopes of 13C and 15N, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: July 24, 2018
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Hidehito Tochio, Yu Kimura, Masahiro Shirakawa, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando, Masato Minami, Fumio Yamauchi, Tetsuya Yano, Hidetoshi Tsuzuki
  • Aza metal complexes
    Patent number: 9115153
    Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: August 25, 2015
    Assignee: Canon Kabushiki Kaisha
    Inventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano
  • POLYMER, CONTRAST AGENT FOR NUCLEAR MAGNETIC RESONANCE ANALYSIS OR MAGNETIC RESONANCE IMAGING USING THE POLYMER, COMPOUND AND METHOD OF NUCLEAR MAGNETIC RESONANCE ANALYSIS AND METHOD OF MAGNETIC RESONANCE IMAGING USING THE POLYMER
    Publication number: 20150071861
    Abstract: As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of a 1H—13C—15N, 1H—15N—13C or 1H—13C—13C bond, that is, a structure labeled with stable isotopes of 13C and 15N, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.
    Type: Application
    Filed: May 22, 2013
    Publication date: March 12, 2015
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Hidehito Tochio, Yu Kimura, Masahiro Shirakawa, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando, Masato Minami, Fumio Yamauchi, Tetsuya Yano, Hidetoshi Tsuzuki
  • Aza metal complexes
    Publication number: 20140275521
    Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.
    Type: Application
    Filed: May 28, 2014
    Publication date: September 18, 2014
    Applicant: Canon Kabushiki Kaisha
    Inventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano
  • AZA compounds and production method thereof, and metal complexes as MRI contrast agents
    Patent number: 8772475
    Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: July 8, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano
  • AZA COMPOUNDS AND PRODUCTION METHOD THEREOF, AND METAL COMPLEXES AS MRI CONTRAST AGENTS
    Publication number: 20110028713
    Abstract: A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.
    Type: Application
    Filed: November 28, 2008
    Publication date: February 3, 2011
    Applicants: KYOTO UNIVERSITY, CANON KABUSHIKI KAISHA
    Inventors: Teruyuki Kondo, Hiroshi Tsujita, Zainul Abedin Siddique, Shingo Matsuki, Hiroki Miura, Hidehito Tochio, Tetsuya Matsuda, Michiko Narazaki, Hidetoshi Tsuzuki, Katsuaki Kuge, Yoshinori Tomida, Kimihiro Yoshimura, Tetsuya Yano