Abstract: A kit for preparation of a sustained-release topically administered agent includes: a first agent comprising liquid containing a local anesthetic medication; a second agent comprising powder containing a crosslinking polysaccharide derivative for forming a biodegradable gel; and a third agent comprising liquid containing a pH adjuster, wherein the third agent adjusts a pH to a condition suitable for forming a biodegradable gel containing said local anesthetic medication when said first agent, said second agent, and said third agent are mixed. Said biodegradable gel containing said local anesthetic medication is formed when said first agent, said second agent, and said third agent are mixed. A pH of said biodegradable gel containing said local anesthetic medication that is formed when said first agent, said second agent, and said third agent are mixed is in a range of 6.4 to 12.

Abstract: A gel type local anesthetic agent of the present invention is a local anesthetic agent consisting of a local anesthetic having a tertiary amine and glycyrrhizic acid in which the local anesthetic and glycyrrhizic acid are gelated to form a gel type.

Abstract: A drug-filled synthetic resin ampule 1m includes an ampule main body 2m and a drug stored in the ampule main body. The ampule main body includes a distal end portion, a hollow portion having a drug storing portion, and an annular breakable portion provided between a lower portion of the distal end portion and an upper portion of the hollow portion. The ampule main body includes no inner lateral surface protrusion on an inner lateral portion thereof which is located on a side toward the distal end portion with respect to the annular breakable portion. The distal end portion is configured such that an inner top surface of the distal end portion is located near a plane defined by the annular breakable portion and an inner surface of the distal end portion is a low-drug-retention surface.

Abstract: A sustained-release topically administered agent includes a compound having a pharmacological action, a crosslinking polysaccharide derivative having at least one active ester group, introduced into a side chain of a polysaccharide, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked substance by a covalent bond between the active ester group and the active hydrogen-containing group; and a pH adjuster for adjusting a pH condition suitable for forming a biodegradable gel containing the compound when the sustained-release topically administered agent is mixed. The sustained-release topically administered agent forms the biodegradable gel containing the compound when the sustained-release topically administered agent is mixed. The pH of the biodegradable gel is not less than five.

Abstract: A gel type local anesthetic agent of the present invention is a local anesthetic agent consisting of a local anesthetic having a tertiary amine and glycyrrhizic acid in which the local anesthetic and glycyrrhizic acid are gelated to form a gel type.