Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: Provided is a chimeric target factor receptor capable of activating an antigen-presenting cell such as a dendritic cell in a target-factor-specific manner. The chimeric target factor receptor contains a target factor-binding domain, a transmembrane domain, and an intracellular domain containing a TLR intracellular domain.

Abstract: Provided are a combination drug for treating a malignant tumor, a pharmaceutical composition for treating a malignant tumor, and a pharmaceutical composition for malignant tumor treatment that have an exceptional antitumor effect. A malignant tumor can be treated by a combination drug containing a first medicine that includes an oncolytic virus belonging to the herpes simplex viruses type 1 as an active ingredient, and a second medicine that includes an interferon gene stimulating factor agonist as an active ingredient.

Abstract: A speech segment to be analyzed is cut out with a window having a length of a plurality of pitch periods for RK model voicing source parameter estimation. GCIs are all estimated for a plurality of voicing source pulses. Based on such estimations, an RK model voicing source waveform is generated, its relationship with the speech segment is analyzed by ARX system identification, and then a glottal transform function is estimated. While this process repeated, when GCIs converge at a predetermined value, the identification is completed. Accordingly, a high quality analysis-synthesis system, which isolates voicing source parameters of speech signals from vocal tract parameters thereof with high accuracy, can be realized.

Abstract: An active vibration controller includes acceleration detectors for generating output signals on the basis of vibrations of a vehicle, speakers provided in a vehicle's cabin, microphones provided in the vehicle's cabin for receiving generated sounds from the speakers and road noises generated on the basis of running of the vehicle, and adaptive digital filters using output signals from the acceleration detectors as inputs for controlling filter factors on the basis of an RLS algorithm to minimize levels of output signals from the microphones in response to output signals from the microphones and output signals from the acceleration detectors through use of a transfer function matched to the transfer function of the vehicle's cabin in a sound field between the speakers and the microphones. The controller minimized levels of output signals from the microphones by developing an applied output signal to the speakers.

Abstract: A phoneme information extracting apparatus includes correlation data generators for successively generating correlation data representing the correlation between the acoustic power spectrum data corresponding to input voice and power spectrum data of various reference phonemes, selection circuits for successively transferring these correlation data when they detect that three or more successive correlation data have values greater than a predetermined value, maximum data hold circuits for holding the maximum correlation data among the correlation data transferred from the respective selection circuits, and a phoneme determination circuit for determining the optimum phoneme by detecting one of the data hold circuits that is holding the maximum correlation data among the correlation data held in the data hold circuits.