Patents by Inventor Hideki Kawasome

Hideki Kawasome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-?, and IL-4
    Patent number: 8450352
    Abstract: Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i)-(iii): (i) —CH(OH)—B— wherein B is a C1-6 alkylene group; (ii) —COCH(COOR3)-Bb- wherein R3 is a C1-6 alkyl group and Bb is a C1-6 alkylene group; and (iii) -Bc- wherein Bc is a C2-6 alkylene group, and include optical isomers and salts of the compounds.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: May 28, 2013
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki
  • Thiazole Compound and Use Thereof
    Publication number: 20100094002
    Abstract: Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i)-(iii): (i) —CH(OH)-B- wherein B is a C1-6 alkylene group; (ii) —COCH(COOR3)-Bb- wherein R3 is a C1-6 alkyl group and Bb is a C1-6 alkylene group; and (iii) -Bc- wherein Bc is a C2-6 alkylene group, and include optical isomers and salts of the compounds.
    Type: Application
    Filed: December 15, 2009
    Publication date: April 15, 2010
    Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki
  • Thiazole compound and use thereof
    Patent number: 7655680
    Abstract: Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) —CO—B— wherein B is a C1-6 alkylene group and (ii) —CO—Ba— wherein Ba is a C2-6 alkenylene group, and include optical isomers and salts of the compounds.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: February 2, 2010
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki
  • Thiazole Compound and Use Thereof
    Publication number: 20080039511
    Abstract: An object of the present invention is to provide a novel thiazole compound with specific inhibitory activity against phosphodiesterase 4.
    Type: Application
    Filed: May 16, 2005
    Publication date: February 14, 2008
    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
    Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki