Abstract: A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.

Abstract: A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.

Abstract: A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.

Abstract: There is provided a technique for reducing a burden on a patient during an examination and presenting an objective examination result. An ophthalmological diagnosis device (102) for providing information to assist in making a diagnosis on a cornea includes: an input unit that receives an input of video image data from an external device (101); an output unit that outputs image data; a storage unit that stores an evaluation criterion for an injury of the cornea; and a processing unit that processes data.

Abstract: A method for changing a condition of an eyelid of a hairless animal, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Abstract: A method for suppressing obstruction of meibomian gland in a mammalian subject, the method comprising administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to an eye of the mammalian subject 1 to 2 times per day.

Abstract: A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Abstract: A method for changing a condition of an eyelid of a hairless animal, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Abstract: A method for treatment of meibomian gland dysfunction in a mammalian subject, the method involving administering to the mammalian subject an eye drop comprising 0.01 to 0.5% (w/v) of sirolimus or a pharmaceutically acceptable salt thereof as a sole active ingredient, wherein the eye drop is administered to the eyes of the mammalian subject 1 to 2 times per day.

Abstract: With a method of storing meat stored in a refrigerator or a freezer after a lump of meat is prepared into small portions, which includes irradiating the meat with positive ions and negative ions before storage in the refrigerator or the freezer, a method of extending a durable life of food requiring storage by refrigeration, a method of suppressing growth of fungi developed at a surface of food requiring storage by refrigeration, and an ion irradiation apparatus which can suitably be used for these methods, a method allowing suppression of growth of fungi adhering to food (in particular, meat) requiring storage by refrigeration, a method of thereby extending a durable life of food requiring storage by refrigeration, and an apparatus which can suitably be used for these methods are provided.

Abstract: A compound represented by the formula (1): wherein R1 represents a hydroxyl group, a dimethylphosphynoyloxy group, etc.; and R2 and R3 represent a methoxy group, etc., or a pharmaceutically acceptable salt thereof can reduce a score of telangiectasia around the meibomian gland orifices and a number of obstruction at the orifices, so that it is useful as a prophylactic and/or therapeutic agent for meibomian gland dysfunction.

Abstract: A method for changing a condition of an eyelid of a hairless animal, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Abstract: A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

Abstract: One circuit generates a constant positive potential, another circuit generates a constant negative potential. The positive potential and the negative potential are applied to a magneto-resistive head that reads data from and writes data to a magnetic disk. The positive potential is generated using a positive voltage source, an operational amplifier, and an NMOS transistor. The negative potential is generated using a negative voltage source, an operational amplifier, and a PMOS transistor.

Abstract: An electronic device including a vibration generator having an eccentric weight member attached to the output of a motor. The motor is accommodated into a bracket made from elastic material, and the bracket is held in a casing. The bracket has a prism-shaped body, and has a through hole in which the motor is tightly fitted formed the central portion of the body, and the peripheral wall defining the through hole is formed with a slit cut from one end face of the body to a central portion of the body in a specified depth. Accordingly, the vibration generator is accommodated into the bracket with great ease. Moreover, the motor of the vibration generator is unlikely to change easily its rotating angle posture in the interior of the bracket while the bracket is assembled into a casing.

Abstract: One circuit generates a constant positive potential, other circuit generates a constant negative potential. The positive potential and the negative potential are applied to a magneto-resistive head that reads or writes data from/to a magnetic disk. The positive potential is generated using a positive voltage source, an operational amplifier, and an NMOS transistor. The negative potential is generated using of a negative voltage source, an operational amplifier, and a PMOS transistor.

Abstract: A portable electronic device comprises a casing 1, a first circuit board 3 provided in the interior of the casing 1, and a circuit module 5 attached to the first circuit board 3. The circuit module 5 comprises a chassis 51 engaged with the first circuit board 3 and a second circuit board 32 fixed to the chassis 51. A male connector 61 attached to one circuit board and a female connector 62 attached to the other circuit board are engaged with each other to have the both circuit boards electrically connected. The chassis 51 is formed with a pair of arms 52, 52 holding and supporting the respective end faces of the first circuit board 3 on respective end portions of the chassis 51. The pair of arms 52, 52 extends to the first circuit board 3 on respective end portions of the chassis 51, and an end portion of each arm 52 is held between an end face of the first circuit board 3 and the inner face of the casing 1.

Abstract: An object of the invention is to provide a communication apparatus which commonly uses a function circuit required both for a voice communication and an image communication so that the number of parts of the apparatus is reduced and the apparatus is realized at a low cost; therefore the communication apparatus 1 using a telephone line according to the invention includes a speech circuit 6 for use in a telephone set, wherein the speech circuit 6 is connected to the telephone line for selectively transmitting and receiving a voice signal and an image signal via the telephone line and responds to an output of an operation panel 7 for instructing a start of transmitting the voice signal and the image signal so that the telephone line L is closed by controlling a circuit control circuit 3 for closing and opening the telephone line thereby separating a modem 11 connected to the circuit control circuit 3 for transmitting and receiving an image signal via the telephone line L upon an instruction being given to start

Abstract: A semiconductor device includes a power transistor group and a signal circuit on the same substrate. The substrate is grounded at an isolation region at an end of the substrate adjacent to the power transistor group so that the grounded portion of the substrate is distant from the signal circuit.

Abstract: An alarm tag releasing device is provided for a theft monitoring device. The theft monitoring device has a gate installed in a desired position and producing a theft monitoring region of a predetermined range by transmitting radio waves at a predetermined wavelength. A buzzer tag is attached to a protected item by a built-in lock mechanism so as not to be detached, and an alarm circuit operated by a built-in battery to sound an alarm when the radio waves at the predetermined wavelength are received when the buzzer tags enters the monitoring region, said alarm tag releasing device comprising: an insertion part having a shape corresponding to the outer diameter of the buzzer tag and into which the buzzer tag can be inserted, such that the lock mechanism provided in the buzzer tag is unlocked when the buzzer tag is inserted into the insertion part.