Abstract: The present invention provides an amine derivative having a DYRK-inhibiting activity and represented by formula (1): wherein A1, A2, L1, L2, X, Z, R1 and R4 are as defined in the description, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a compound that has an inhibitory effect on DYRK and that is represented by general formula (I): wherein Q, R1, R2 and R3 are as defined in the description.

Abstract: A jewelry item includes a thin piece member formed from a gold alloy containing gold (Au) as a first metal element and a second metal element other than gold (Au), a frame member including a third metal element other than the first metal element and the second metal element and a fourth metal element as a metal for an alloy of the third metal, forming a bond with and surrounding a peripheral edge of the thin piece member, and a compound layer containing the first metal element, the second metal element, the third metal element and the fourth metal element is interposed between the thin piece member and the frame member.

Abstract: The present invention provides a quinazoline derivative represented by the following formula (I): wherein R1 and R2 represent a hydrogen atom, a halogen atom, or a lower alkyl group optionally having a substituent; Z represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent; and Q represents a bicyclic heteroaryl group optionally having a substituent, or a pharmaceutically acceptable salt thereof. Since the compound has an inhibitory effect on the Wnt/?-catenin signaling pathway and exhibits an antitumor effect, it is useful as a medicine.

Abstract: The present invention provides a quinazoline derivative represented by the following formula (I): wherein R1 and R2 represent a hydrogen atom, a halogen atom, or a lower alkyl group optionally having a substituent; Z represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent; and Q represents a bicyclic heteroaryl group optionally having a substituent, or a pharmaceutically acceptable salt thereof. Since the compound has an inhibitory effect on the Wnt/?-catenin signaling pathway and exhibits an antitumor effect, it is useful as a medicine.

Abstract: The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a retardation film using polyester having a photoelastic coefficient of ?40×10?12 Pa?1 to 40×10?12 Pa?1. The present invention also relates to a polyester resin for optical use which contains a phosphorus compound, and an alicyclic component and a fluorene derivative component as constituents, and satisfies the following equations (6) and (7): 100° C.?glass transition temperature?150° C.??(6) and 1.0?(Ma/2+Mb+Mc)/P?5.0??(7), wherein Ma is the number of moles of an alkali metal element contained in 1 ton of the polyester resin, Mb is the number of moles of an alkaline earth metal element contained in 1 ton of the polyester resin, Mc is the sum of the number of moles of a zinc element (Zn), a cobalt element (Co) and a manganese element (Mn) contained in 1 ton of the polyester resin, and P is the number of moles of a phosphorus element contained in 1 ton of the polyester resin.

Abstract: The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.

Abstract: A polyamide having at least an alicyclic or aromatic group exhibiting a light transmittance of 80% or more in the wavelength region of 450 to 700 nm is produced by using an aramide polymer comprising specific structural units at an amount of 50 mol % or more. Colorless transparent alicyclic or aromatic polyamide films having high rigidity and high thermal resistance are provided by using the polyamide. Further, the invention provides various optical members made by using the polyamide or the polyamide films, and polyamide copolymers.

Abstract: A compound having an oxadiazole structure which is obtained by dehydration-cyclization of a compound having a carbohydrazide structure using a chemical agent selected from acids and bases. The dehydration-cyclization of the compound having a carbohydrazide structure can be conducted under mild conditions at low cost.

Abstract: An object of the present invention is to provide compounds which are useful as protein kinase inhibitors.

Abstract: The present invention relates to Traf2- and Nck-interacting kinase (TNIK) inhibitors, pharmaceutical compositions, and methods for the treatment of cancer patients with TNIK inhibitors. And the present invention relates to a novel aminothiazole derivatives. The TNIK inhibitors are showed by a next formula (I). Wherein R1, R2, R3, R4, R5 and R6 represent independently a hydrogen atom or a substituent group.

Abstract: The present invention relates to compositions and methods for the treatment of cancer patients with Traf2- and Nck-interacting kinase (TNIK) inhibitors. More particularly, the present invention relates to pharmaceutical compositions comprising TNIK inhibitor and a pharmaceutically acceptable carrier, and to methods for treating the TNIK inhibitor administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. And the present invention relates to a novel aminothiazole derivatives.

Abstract: A compound having an oxadiazole structure which is obtained by dehydration-cyclization of a compound having a carbohydrazide structure using a chemical agent selected from acids and bases. The dehydration-cyclization of the compound having a carbohydrazide structure can be conducted under mild conditions at low cost.

Abstract: The present invention relates to a retardation film using polyester having a photoelastic coefficient of ?40×10?12 Pa?1 to 40×10?12 Pa?1. The present invention also relates to a polyester resin for optical use which contains a phosphorus compound, and an alicyclic component and a fluorene derivative component as constituents, and satisfies the following equations (6) and (7): 100° C.?glass transition temperature?150° C.??(6) and 1.0?(Ma/2+Mb+Mc)/P?5.0??(7), wherein Ma is the number of moles of an alkali metal element contained in 1 ton of the polyester resin, Mb is the number of moles of an alkaline earth metal element contained in 1 ton of the polyester resin, Mc is the sum of the number of moles of a zinc element (Zn), a cobalt element (Co) and a manganese element (Mn) contained in 1 ton of the polyester resin, and P is the number of moles of a phosphorus element contained in 1 ton of the polyester resin.

Abstract: A compound having an oxadiazole structure which is obtained by dehydration-cyclization of a compound having a carbohydrazide structure using a chemical agent selected from acids and bases. The dehydration-cyclization of the compound having a carbohydrazide structure can be conducted under mild conditions at low cost.

Abstract: An aromatic polymer containing aromatic polyamide structural units and aromatic carbohydrazide structural units at a specific ratio is disclosed. A film having a high Young's modulus, high elongation at break and low moisture absorption can be formed from such an aromatic polymer. Dehydration cyclization of a compound having a carbohydrazide structure can be conducted under mild conditions at low cost by causing the chemical reaction using a chemical which is selected from the acids and bases.

Abstract: An acrylic resin film, in which acrylic elastic particles are mixed with an acrylic resin containing glutaric anhydride units, has a total light transmittance of 91% or more, a haze value of 1.5% or less, a folding endurance value (times) of 20 or more, and a heat shrinkage rate of less than 5% at least in either the machine direction or the transverse direction in a heat shrinkage test.

Abstract: This invention is directed to polyimide films having a carbon nanotube filler to provide a surface resistivity in a range from 50 ohm/square to 1.0×1015 ohms/square. The electrically conductive polyimides of the present invention have an excellent balance of properties relative to conventional polyimides having a conductive filler, due at least in part to the film's water content, degree of imidization and polymer orientation.