Patents by Inventor Hideki OOMIYA

Hideki OOMIYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240351978
    Abstract: The present invention provides a method for industrially producing a highly pure aromatic nitrile compound and a highly pure aromatic carboxylic acid compound safely and highly efficiently at low costs. Compound (2) is subjected to Willgerodt reaction in the presence of an additive as necessary, and the obtained amide compound (3) is hydrolyzed and neutralized to give carboxylic acid compound (4). Carboxylic acid compound (4) is reacted with a halogenating agent in the presence of a catalyst as necessary in an organic solvent, and further reacted with an amidating agent, and the obtained amide compound (5) or (6) is reacted with a dehydrating agent to give nitrile compound (1). Alternatively, carboxylic acid compound (4) is reacted with a halogenating agent and a compound represented by the formula R6SO2R7 in the presence of a catalyst as necessary in an organic solvent to give nitrile compound (1).
    Type: Application
    Filed: June 10, 2024
    Publication date: October 24, 2024
    Applicant: API CORPORATION
    Inventors: Masaki NAGAHAMA, Hideki OOMIYA, Daiki OKADO, Hirotsugu TANIIKE
  • Patent number: 12054448
    Abstract: The present invention provides a method for industrially producing a highly pure aromatic nitrile compound and a highly pure aromatic carboxylic acid compound safely and highly efficiently at low costs. Compound (2) is subjected to Willgerodt reaction in the presence of an additive as necessary, and the obtained amide compound (3) is hydrolyzed and neutralized to give carboxylic acid compound (4). Carboxylic acid compound (4) is reacted with a halogenating agent in the presence of a catalyst as necessary in an organic solvent, and further reacted with an amidating agent, and the obtained amide compound (5) or (6) is reacted with a dehydrating agent to give nitrile compound (1). Alternatively, carboxylic acid compound (4) is reacted with a halogenating agent and a compound represented by the formula R6SO2R7 in the presence of a catalyst as necessary in an organic solvent to give nitrile compound (1).
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: August 6, 2024
    Assignee: API CORPORATION
    Inventors: Masaki Nagahama, Hideki Oomiya, Daiki Okado, Hirotsugu Taniike
  • Publication number: 20210078940
    Abstract: The present invention provides a method for industrially producing a highly pure aromatic nitrile compound and a highly pure aromatic carboxylic acid compound safely and highly efficiently at low costs. Compound (2) is subjected to Willgerodt reaction in the presence of an additive as necessary, and the obtained amide compound (3) is hydrolyzed and neutralized to give carboxylic acid compound (4). Carboxylic acid compound (4) is reacted with a halogenating agent in the presence of a catalyst as necessary in an organic solvent, and further reacted with an amidating agent, and the obtained amide compound (5) or (6) is reacted with a dehydrating agent to give nitrile compound (1). Alternatively, carboxylic acid compound (4) is reacted with a halogenating agent and a compound represented by the formula R6SO2R7 in the presence of a catalyst as necessary in an organic solvent to give nitrile compound (1).
    Type: Application
    Filed: April 26, 2019
    Publication date: March 18, 2021
    Applicant: API CORPORATION
    Inventors: Masaki NAGAHAMA, Hideki OOMIYA, Daiki OKADO, Hirotsugu TANIIKE
  • Patent number: 10815201
    Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: October 27, 2020
    Assignee: API CORPORATION
    Inventors: Naoyuki Watanabe, Takanobu Iura, Hideki Oomiya, Masaki Nagahama
  • Publication number: 20200283390
    Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
    Type: Application
    Filed: April 17, 2020
    Publication date: September 10, 2020
    Applicant: API CORPORATION
    Inventors: Naoyuki WATANABE, Takanobu IURA, Hideki OOMIYA, Masaki NAGAHAMA
  • Patent number: 10676441
    Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: June 9, 2020
    Assignee: API CORPORATION
    Inventors: Naoyuki Watanabe, Takanobu Iura, Hideki Oomiya, Masaki Nagahama
  • Publication number: 20180222865
    Abstract: Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 9, 2018
    Applicant: API CORPORATION
    Inventors: Naoyuki WATANABE, Takanobu IURA, Hideki OOMIYA, Masaki NAGAHAMA