Abstract: Provided is an electrostimulation device that outputs an electrical signal, the electrical signal obtained by repeatedly outputting a fifth electrical signal comprising a first electrical signal whose amplitude in a first time becomes larger from a first amplitude, a second electrical signal whose amplitude in a second time is maintained to a second amplitude, a third electrical signal whose amplitude in a third time becomes smaller to a third amplitude, and a fourth electrical signal whose amplitude in a fourth time is maintained to a fourth amplitude; and the first electrical signal output in a sixth time, that is obtained by repeatedly outputting an eighth electrical signal comprising a sixth electrical signal having a first frequency, the sixth electrical signal that is off in a seventh time, wherein the first frequency is controlled via first frequency control of changing from a second frequency to a third frequency.

Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].

Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].

Abstract: The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

Abstract: An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

Abstract: An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH?, R1 represents a group -Z-R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH?; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

Abstract: A coaxial connector, in which control of impedance is facilitated, and in which fluctuations in impedance are extremely small. The coaxial connector includes an inner contact, having a crimp connection portion which is crimped onto an inner conductor of a coaxial cable, an outer contact, which is crimped onto an outer conductor of the coaxial cable and an insulator (dielectric), which is provided between the inner contact and the outer contract. Concavities are formed in the outer surface of the dielectric at positions corresponding to the crimp connection portion of the inner contact The concavities control the characteristic impedance of the coaxial connector.

Abstract: A high frequency switch is provided with an input terminal, an output terminal, a first diode, a second diode, a first resistor, a third diode and a second resistor. The first diode is provided in a signal line, which connects the input terminal to the output terminal. The first diode has an input end and an output end. The second diode has one end, which is connected to the input end side of the first diode. The first resistor is provided in a terminated line, which is connected to another end of the second diode. The third diode has one end, which is connected to the output end side of the first diode. The second resistor is provided in a terminated line, which is connected to another end of the third diode.

Abstract: A phase shifter according to this invention includes a circuit board having a semi-insulating layer. An active layer is formed in a transmission line forming portion on one surface side of the semi-insulating layer, a first ground conductive layer is formed on the other surface side, a transmission line is formed on the upper side of the active layer, and a second ground conductive layer is formed on the transmission line forming surface of the semi-insulating layer in close proximity to one side of the transmission line. If a bias voltage of negative polarity is applied to the transmission line, reverse bias is applied to the active layer to form a depletion layer and capacitance is equivalently connected to the transmission line having inductance. A phase shift amount can be freely controlled by changing the value of the capacitance according to the bias voltage.

Abstract: A phase shifter according to this invention includes a circuit board having a semi-insulating layer. An active layer is formed in a transmission line forming portion on one surface side of the semi-insulating layer, a first ground conductive layer is formed on the other surface side, a transmission line is formed on the upper side of the active layer, and a second ground conductive layer is formed on the transmission line forming surface of the semi-insulating layer in close proximity to one side of the transmission line. If a bias voltage of negative polarity is applied to the transmission line, reverse bias is applied to the active layer to form a depletion layer and capacitance is equivalently connected to the transmission line having inductance. A phase shift amount can be freely controlled by changing the value of the capacitance according to the bias voltage.

Abstract: A coaxial connector, in which control of impedance is facilitated, and in which fluctuations in impedance are extremely small. The coaxial connector includes an inner contact, having a crimp connection portion which is crimped onto an inner conductor of a coaxial cable, an outer contact, which is crimped onto an outer conductor of the coaxial cable and an insulator (dielectric), which is provided between the inner contact and the outer contract. Concavities are formed in the outer surface of the dielectric at positions corresponding to the crimp connection portion of the inner contact The concavities control the characteristic impedance of the coaxial connector.

Abstract: A high frequency switch is provided with an input terminal, an output terminal, a first diode, a second diode, a first resistor, a third diode and a second resistor. The first diode is provided in a signal line, which connects the input terminal to the output terminal. The first diode has an input end and an output end. The second diode has one end, which is connected to the input end side of the first diode. The first resistor is provided in a terminated line, which is connected to another end of the second diode. The third diode has one end, which is connected to the output end side of the first diode. The second resistor is provided in a terminated line, which is connected to another end of the third diode.

Abstract: A casing for an electronic control device, by which a cover and a casing body are reliably sealed up while preventing the cover from warping or from being distorted, although the cover is made of a thin sheet material. The electronic control device casing comprises: a casing body having an opening in its upper face portion for casing a printed circuit board; a cover made of a sheet material for closing the opening of the casing body; a groove portion formed in the open edge portion of the casing body; a liquid sealing material fitted in the groove portion for sealing the open edge portion of the casing body and the flange portion of the cover; and a ridge portion having a generally U-shaped section and formed on the flange portion of the cover for being fitted in the groove portion of the casing body.

Abstract: A phase shifter according to this invention includes a circuit board having a semi-insulating layer. An active layer is formed in a transmission line forming portion on one surface side of the semi-insulating layer, a first ground conductive layer is formed on the other surface side, a transmission line is formed on the upper side of the active layer, and a second ground conductive layer is formed on the transmission line forming surface of the semi-insulating layer in close proximity to one side of the transmission line. If a bias voltage of negative polarity is applied to the transmission line, reverse bias is applied to the active layer to form a depletion layer and capacitance is equivalently connected to the transmission line having inductance. A phase shift amount can be freely controlled by changing the value of the capacitance according to the bias voltage.

Abstract: A casing for an electronic control device, by which a cover and a casing body are reliably sealed up while preventing the cover from warping or from being distorted, although the cover is made of a thin sheet material. The electronic control device casing comprises: a casing body having an opening in its upper face portion for casing a printed circuit board; a cover made of a sheet material for closing the opening of the casing body; a groove portion formed in the open edge portion of the casing body; a liquid sealing material fitted in the groove portion for sealing the open edge portion of the casing body and the flange portion of the cover; and a ridge portion having a generally U-shaped section and formed on the flange portion of the cover for being fitted in the groove portion of the casing body.

Abstract: A casing for an electronic control device, by which a cover and a casing body are reliably sealed up while preventing the cover from warping or from being distorted, although the cover is made of a thin sheet material. The electronic control device casing comprises: a casing body having an opening in its upper face portion for casing a printed circuit board; a cover made of a sheet material for closing the opening of the casing body; a groove portion formed in the open edge portion of the casing body; a liquid sealing material fitted in the groove portion for sealing the open edge portion of the casing body and the flange portion of the cover; and a ridge portion having a generally U-shaped section and formed on the flange portion of the cover for being fitted in the groove portion of the casing body.