Patents by Inventor Hideko Otake

Hideko Otake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-acetylmannosamine dehydrogenase gene and novel recombinant DNA as well as a method for production of N-acetylmannosamine dehydrogenase
    Patent number: 5942427
    Abstract: N-acetylmannosamine dehydrogenase gene derived from a microorganism belonging to the genus Flavobacterium, e.g., Flavobacterium sp. No. 141-8 strain and defined by a specific restriction enzyme map which encodes 271 amino acid sequence. Using the recombinant DNA, N-acetylmannosamine dehydrogenase can be produced in a simpler manner in an industrial scale. The enzyme is useful for quantitative determination of sialic acid.
    Type: Grant
    Filed: December 27, 1990
    Date of Patent: August 24, 1999
    Assignees: Noda Institute for Scientific Research, Kikkoman Corporation
    Inventors: Hideko Otake, Yasuji Koyama, Tatsuo Horiuchi, Eiichi Nakano
  • Variant E1 protein gene for pyruvate dehydrogenase complex and variant E1 protein of pyruvate dehydrogenase complex
    Patent number: 5432071
    Abstract: The present invention relates to variant E.sub.1 protein of pyruvate dehydrogenase complex of high activity in which arginine at the 146-position is replaced by proline in the amino acid sequence of wild-type E.sub.1 protein of pyruvate dehydrogenase complex, a gene coding for said variant E.sub.1 protein, a novel recombinant DNA comprising said variant E.sub.1 protein-encoding gene inserted in a vector DNA, and a process for producing variant E.sub.1 protein by said recombinant DNA. The present invention provides the variant E.sub.1 protein of pyruvate dehydrogenase complex of high activity.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: July 11, 1995
    Assignee: Kikkoman Corporation
    Inventors: Toshio Ichikawa, Yasuji Koyama, Hideko Otake, Eiichi Nakano