Patents by Inventor Hidekuni Yamakawa

Hidekuni Yamakawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A HISTONE DEACETYLASE INHIBITOR HAVING A NITROGEN-CONTAINING AROMATIC HETEROCYCLYL GROUP
    Publication number: 20230119479
    Abstract: A novel compound having HDAC2 inhibitory activity is provided. A compound represented by Formula (I): wherein the group represented by Formula: is a group represented by Formula: or the like, wherein R3 is each independently amino or the like, and n is an integer of 0 to 4, X1 is N or the like, X2 is N or the like, R4 and R5 are each independently a hydrogen atom or the like, R1 is substituted with Substituent group C or unsubstituted non-aromatic carbocyclyl or the like, Substituent group C is halogen or the like, and R2 is a hydrogen atom, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 9, 2020
    Publication date: April 20, 2023
    Inventors: Kosuke ANAN, Hidekuni YAMAKAWA, Ken YOSHIHARA, Kenji NAKAHARA, Kenji TAKAYA, Keisuke MIZOTE, Hiroyuki KAI
  • TARGETING THE HDAC2-SP3 COMPLEX TO ENHANCE SYNAPTIC FUNCATION
    Publication number: 20190015473
    Abstract: The present disclosure provides, in some embodiments, methods for treating a neurodegenerative disease in a subject using a histone deacetylase 2 (HDAC2)/Sp3 inhibitor, which may be a peptide inhibitor comprising the carboxyl-terminus of HDAC2, and related compositions.
    Type: Application
    Filed: July 12, 2018
    Publication date: January 17, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Li-Huei Tsai, Hidekuni Yamakawa, Jemmie Cheng, Fan Gao, Jay Penney
  • Anti-sAPP? antibody
    Patent number: 9222947
    Abstract: Provided are a monoclonal antibody capable of specifically recognizing a specific region of sAPP ? or a fragment of said antibody and an assay method and an assay kit using the same, in order to accurately assay sAPP? contained in a biological sample.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: December 29, 2015
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Tatsuya Takahashi, Junji Onoda, Yasunobu Yoshida, Shoji Yamane, Kouhei Nishitomi, Hidekuni Yamakawa, Akira Yamauchi, Atsushi Morita, Isao Fukuda
  • ANTI-sAPPbeta ANTIBODY
    Publication number: 20150111231
    Abstract: Provided are a monoclonal antibody capable of specifically recognizing a specific region of sAPP ? or a fragment of said antibody and an assay method and an assay kit using the same, in order to accurately assay sAPP? contained in a biological sample.
    Type: Application
    Filed: February 1, 2013
    Publication date: April 23, 2015
    Inventors: Tatsuya Takahashi, Junji Onoda, Yasunobu Yoshida, Shoji Yamane, Kouhei Nishitomi, Hidekuni Yamakawa, Akira Yamauchi, Atsushi Morita, Isao Fukuda