Abstract: Provided is a valve device and a shock absorber that can prevent them from being in a failure state at the normal time and can freely set a passive valve even when both pressure control and passage opening/closing are performed by a solenoid valve. For this reason, the valve device includes a first passage and a second passage connected downstream of the pressure introducing passage, a solenoid valve that opens the first passage to control the upstream pressure and closes the second passage when energized, and that closes the first passage and opens the second passage when not energized, and a passive valve provided downstream of the solenoid valve in the second passage.

Abstract: Provided is a method for producing transformed cells, comprising an introduction step of contacting an introduction liquid comprising a molecule of interest with a target cell to introduce the molecule of interest into the target cell, wherein, in the introduction step, the molecule of interest is introduced via endocytosis into the target cell, a trait is conferred, deleted, or maintained by the introduction of the molecule of interest, and the molecule of interest such as a vector added exogenously does not then remain in an established cell.

Abstract: Provided is a valve device and a shock absorber that can prevent them from being in a failure state at the normal time and can freely set a passive valve even when both pressure control and passage opening/closing are performed by a solenoid valve. For this reason, the valve device includes a first passage and a second passage connected downstream of the pressure introducing passage, a solenoid valve that opens the first passage to control the upstream pressure and closes the second passage when energized, and that closes the first passage and opens the second passage when not energized, and a passive valve provided downstream of the solenoid valve in the second passage.

Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore, upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.

Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore, upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.

Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.

Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.

Abstract: In one aspect of an embodiment, a computer determines an identity of the cells with a cell shape data, and also determines a correspondence relationship of identification data between a plurality of cell analyzing tables at a different observing times. Also, the computer, based on the correspondence relationship of the identification data, records a plurality of cell analyzing tables at the different observing times in a storage medium by making into a database which can be searched in a direction of a time axis for each of the cells having commonality.

Abstract: Disclosed is a method for producing an iPS cell having a very similar gene expression pattern to that of an ES cell with high efficiency. Specifically disclosed is a method for producing an artificial pluripotent stem cell (an iPS cell), which comprises the steps of: introducing a pluripotency-inducing factor comprising at least an Myc family gene or an Myc family protein into a somatic cell; and culturing the somatic cell in the presence of a sirtuin inhibitor and/or a poly-ADP ribose polymerase (PARP) inhibitor.

Abstract: In one aspect of an embodiment, a computer determines an identity of the cells with a cell shape data, and also determines a correspondence relationship of identification data between a plurality of cell analyzing tables at a different observing times. Also, the computer, based on the correspondence relationship of the identification data, records a plurality of cell analyzing tables at the different observing times in a storage medium by making into a database which can be searched in a direction of a time axis for each of the cells having commonality.