Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.

Abstract: An aggregated cell evaluation apparatus includes a laser light source, a speckle image acquisition unit, an SC calculation unit, an evaluation unit, and a memory unit. The speckle image acquisition unit acquires a two-dimensional speckle image by forward scattered light generated in aggregated cells by irradiation of the aggregated cells with laser light output from the laser light source. The SC calculation unit calculates a speckle contrast value Kn of a speckle image In at each time tn, determines a maximum value Kmax among the speckle contrast values K1 to KN, and normalizes the speckle contrast value Kn at each time tn by the maximum value Kmax to obtain a normalized speckle contrast value Kn?. The evaluation unit evaluates motion of the aggregated cells, based on the normalized speckle contrast value Kn? at each time tn.

Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.

Abstract: The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.

Abstract: An imaging device includes an illumination unit that irradiates a moving object with light A, an optical system that focuses into an image of the object, a detection unit having a light receiving plane on which the image of the object by this optical system is formed, and an analysis unit. The detection unit includes a plurality of light receiving cells d1 to dN which are arrayed in an x direction on the light receiving plane, and is disposed such that the image moves in a y direction on the light receiving plane, the detection unit receives light or does not receive light according to pseudo noise code sequences along the y direction respectively on the plurality of light receiving cells.

Abstract: The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.

Abstract: An observation device is provided with a light source section, a detection section and an arithmetic operation section. The light source section emits light to a moving object from multiple directions. a detection section is disposed on a predetermined plane such that scattered light having an identical scattering angle enters at an identical position, outputs data temporally changing at a frequency corresponding to an amount of Doppler shift of light that reaches at each position on the predetermined plane. An arithmetic operation section performs a one-dimensional Fourier transform with respect to time variables, for data having a position in the first direction on the predetermined plane, a position in the second direction on the predetermined plane, and a time as variables, and extracts data having an identical incident angle relative to the object from the Fourier-transformed data, on the basis of Doppler Effect.

Abstract: The observation device 1 is a device capable of substantially simultaneously acquiring the fluorescence image and the interference image on the common observation plane in the observation object 90 mounted on slide glass 41, and has an excitation light source 11, a filter 12, a dichroic mirror 13, a lens 14, a dichroic mirror 15, an objective lens 16, a filter 17, a fluorescence imaging unit 18, an interference imaging light source 21, a filter 22, a dichroic mirror 23, a lens 24, a half mirror 25, an objective lens 26, a lens 27, a dichroic mirror 28, an interference imaging unit 29, a position detection light source 31, a light detection unit 32, the slide glass 41, an actuator 42, a reference mirror 43, an actuator 44, a control unit 51, and a display unit 52.

Abstract: An aggregated cell evaluation apparatus includes a laser light source, a speckle image acquisition unit, an SC calculation unit, an evaluation unit, and a memory unit. The speckle image acquisition unit acquires a two-dimensional speckle image by forward scattered light generated in aggregated cells by irradiation of the aggregated cells with laser light output from the laser light source. The SC calculation unit calculates a speckle contrast value Kn of a speckle image In at each time tn, determines a maximum value Kmax among the speckle contrast values K1 to KN, and normalizes the speckle contrast value Kn at each time tn by the maximum value Kmax to obtain a normalized speckle contrast value Kn?. The evaluation unit evaluates motion of the aggregated cells, based on the normalized speckle contrast value Kn? at each time tn.

Abstract: Provided is an observation device which can obtain a phase image of a moving object rapidly with high sensitivity even when using a photodetector having a slow read-out speed per pixel. The observation device 1 comprises a light source 10, a first modulator 20, a second modulator 30, a lens 40, a beam splitter 41, a photodetector 46, and an arithmetic unit 50. The lens 40 receives scattered light generated by a moving object 2 and forms a Fourier transform image of the object 2. The photodetector 46 outputs data representing a sum in a v direction of data temporally changing at a frequency corresponding to a Doppler shift frequency of the light having reached each position on a light-receiving surface through the lens 40 at each position in a u direction at each time. The arithmetic unit 50 obtains an image of the object 2 according to the output of the photodetector 46.

Abstract: Provided is an observation device which can obtain a phase image of a moving object rapidly with high sensitivity even when using a photodetector having a slow read-out speed per pixel. The observation device 1 comprises a light source 10, a first modulator 20, a second modulator 30, a lens 40, a beam splitter 41, a photodetector 46, and an arithmetic unit 50. The lens 40 receives scattered light generated by a moving object 2 and forms a Fourier transform image of the object 2. The photodetector 46 outputs data representing a sum in a v direction of data temporally changing at a frequency corresponding to a Doppler shift frequency of the light having reached each position on a light-receiving surface through the lens 40 at each position in a u direction at each time. The arithmetic unit 50 obtains an image of the object 2 according to the output of the photodetector 46.

Abstract: The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.

Abstract: The observation device 1 is a device capable of substantially simultaneously acquiring the fluorescence image and the interference image on the common observation plane in the observation object 90 mounted on slide glass 41, and has an excitation light source 11, a filter 12, a dichroic mirror 13, a lens 14, a dichroic mirror 15, an objective lens 16, a filter 17, a fluorescence imaging unit 18, an interference imaging light source 21, a filter 22, a dichroic mirror 23, a lens 24, a half mirror 25, an objective lens 26, a lens 27, a dichroic mirror 28, an interference imaging unit 29, a position detection light source 31, a light detection unit 32, the slide glass 41, an actuator 42, a reference mirror 43, an actuator 44, a control unit 51, and a display unit 52.

Abstract: The observation device 1 is to observe the surface or the inside of an observation object 9, that has light sources 11 and 12, lenses 21 to 25, an aperture 31, an optical multiplexer 41, an optical demultiplexer 42, a half mirror 43, an image pickup unit 51, an analyzing unit 52, a display unit 53, a light receiving unit 61, a displacement detecting unit 62, a piezoelectric actuator 71, a drive unit 72, a mirror 73, a stage 81, a drive unit 82, and a control unit 90. The analyzing unit 52 determines a complex amplitude of an interference light figure taken as an image by the image pickup unit 51 with a phase shift technique after an optical path difference is set to each target value in sequence, and determines an amount of change per certain time of a phase component of a reflected light generated on the surface or the inside of the observation object 9 on the basis of an absolute value of an amount of change per certain time of the determined complex amplitude and an absolute value of the complex amplitude.

Abstract: An observation device is provided with a light source section, a detection section and an arithmetic operation section. The light source section emits light to a moving object from multiple directions. a detection section is disposed on a predetermined plane such that scattered light having an identical scattering angle enters at an identical position, outputs data temporally changing at a frequency corresponding to an amount of Doppler shift of light that reaches at each position on the predetermined plane. An arithmetic operation section performs a one-dimensional Fourier transform with respect to time variables, for data having a position in the first direction on the predetermined plane, a position in the second direction on the predetermined plane, and a time as variables, and extracts data having an identical incident angle relative to the object from the Fourier-transformed data, on the basis of Doppler Effect.

Abstract: A cell stethoscope 1 comprises a sample image input section 31 for inputting image information of a cell, an image display part 50 for displaying the image information to an observer, an area designation part 40 for designating a fixed area included in the image information in response to an operation carried out by the observer according to the image information displayed by the image display part 50, a frequency conversion section 32 for frequency-converting vibration information of the cell in the fixed area designated by the area designation part 40 into sound information, and a sound output part 60 for outputting the sound information frequency-converted by the frequency conversion section 32 to the observer.

Abstract: An imaging device includes an illumination unit that irradiates a moving object with light A, an optical system that focuses into an image of the object, a detection unit having a light receiving plane on which the image of the object by this optical system is formed, and an analysis unit. The detection unit includes a plurality of light receiving cells d1 to dN which are arrayed in an x direction on the light receiving plane, and is disposed such that the image moves in a y direction on the light receiving plane, the detection unit receives light or does not receive light according to pseudo noise code sequences along the y direction respectively on the plurality of light receiving cells.

Abstract: The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.

Abstract: This blood examination apparatus examines cancer cells mixed in an examination object which is flowing blood, and includes: a flow cell through which the examination object is made to flow; an imaging optical system which light output from the examination object in an examination region in the flow cell enters, the imaging optical system forming an image of the light on a first image plane; a first Fourier transformation optical system which optically two-dimensionally Fourier-transforms the image formed on the first image plane by the imaging optical system to form the Fourier-transformed image on a second image plane; a spatial light filter which selectively allows a portion in a certain range around an optical axis of the first Fourier transformation optical system of the image formed on the second image plane by the first Fourier transformation optical system to pass through; and a second Fourier transformation optical system which optically two-dimensionally Fourier-transforms the portion which has passe

Abstract: Provided is an observation device which can obtain a phase image of a moving object rapidly with high sensitivity even when using a photodetector having a slow read-out speed per pixel. The observation device 1 comprises a light source 10, a first modulator 20, a second modulator 30, a lens 40, a beam splitter 41, a photodetector 46, and an arithmetic unit 50. The lens 40 receives scattered light generated by a moving object 2 and forms a Fourier transform image of the object 2. The photodetector 46 outputs data representing a sum in a v direction of data temporally changing at a frequency corresponding to a Doppler shift frequency of the light having reached each position on a light-receiving surface through the lens 40 at each position in a u direction at each time. The arithmetic unit 50 obtains an image of the object 2 according to the output of the photodetector 46.