Patents by Inventor Hidenao YAMADA
Hidenao YAMADA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230324296Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.Type: ApplicationFiled: January 21, 2021Publication date: October 12, 2023Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Osamu YASUHIKO, Kozo TAKEUCHI, Hidenao YAMADA
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Publication number: 20230245478Abstract: A discrimination device is a device that discriminates whether or not a discrimination target object is a blood cell based on an image of the discrimination target object, and includes a blood cell feature extraction unit that acquires an image of a blood cell and extracts a feature of the blood cell from the acquired image, a discrimination target object feature extraction unit that acquires the image of the discrimination target object and extracts a feature of the discrimination target object from the acquired image, and a discrimination unit that discriminates whether or not the discrimination target object is a blood cell through anomaly detection based on the extracted feature of the blood cell and the feature of the discrimination target object.Type: ApplicationFiled: June 11, 2021Publication date: August 3, 2023Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Fumio HASHIMOTO, Kibo OTE, Hidenao YAMADA, Hirotoshi KIKUCHI, Amane HIROTSU, Shigetoshi OKAZAKI
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Publication number: 20230213432Abstract: An observation apparatus includes a light source unit, an irradiation optical system, an imaging optical system, a modulation unit, an imaging unit, an analysis unit, beam splitters and, and mirrors. The analysis unit obtains a real part of a function ?(t)=log [1+Uobj(t)/Uref(t)], defined by time series data Uobj(t) of a complex amplitude image of object light on an imaging plane and time series data Uref(t) of a complex amplitude image of reference light on the imaging plane, based on time series data I(t) of an intensity image of interference light on the imaging plane and time series data Iref(t) of an intensity image of the reference light on the imaging plane. Further, the analysis unit obtains an imaginary part of ?(t) from the real part of ?(t) using the Kramers-Kronig relations, and further obtains Uobj(t).Type: ApplicationFiled: May 26, 2021Publication date: July 6, 2023Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Osamu YASUHIKO, Hidenao YAMADA
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Patent number: 11630059Abstract: An interference image acquisition apparatus includes a light source, a beam splitter, a second reflection mirror, an imager, and a first reflection mirror. A cell is placed on one side of a transparent material, and the first reflection mirror is placed on the other side of the transparent material. In a two-beam interferometer, an optical path difference between an optical path length of a first light beam reflected by the first reflection mirror and an optical path length of a second light beam reflected by the second reflection mirror is set to a coherence length of light output from the light source or less. The imager acquires an interference image in a state in which the cell is placed at a position conjugate to an imaging plane in a first optical system between the imaging plane and the first reflection mirror.Type: GrantFiled: November 22, 2018Date of Patent: April 18, 2023Assignees: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Toyohiko Yamauchi, Kentaro Goto, Hisayuki Matsui, Satoshi Hirakawa, Hidenao Yamada
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Publication number: 20230078077Abstract: An ocular fundus image processing device acquires a first image generated by irradiating an ocular fundus of a subject with excitation light of a blue wavelength and a second image generated by irradiating the ocular fundus with excitation light of a green wavelength, generates three trained models for predicting a correction factor for calculating a quantity of macular pigment of the subject from input images including the first image and the second image through training using three different initial values, predicts three correction factors by inputting the input images including the first image and the second image to the three trained models, calculates a statistical value of the three correction factors and derives the statistical value as the correction factor of the subject, and calculates a quantity of macular pigment of the subject on the basis of the first image and the correction factor of the subject.Type: ApplicationFiled: January 5, 2021Publication date: March 16, 2023Applicants: HAMAMATSU PHOTONICS K.K., Social Welfare Corporation Seirei Social Welfare CommunityInventors: Kibo OTE, Fumio HASHIMOTO, Hidenao YAMADA, Akira OBANA
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Patent number: 11530434Abstract: An evaluation method is a method for evaluating a cell mass containing a plurality of aggregated cells, and includes an imaging step of capturing an image of light obtained from the cell mass by irradiating the cell mass with light, an analysis step of setting a reference point for the cell mass included in image data obtained by the imaging step, setting sampling circles centered on the reference point, and determining a parameter for a state of the cell mass based on image data included in regions on the sampling circles, and an evaluation step of evaluating the cell mass based on the parameter.Type: GrantFiled: March 13, 2018Date of Patent: December 20, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Kentaro Goto, Toyohiko Yamauchi, Hidenao Yamada
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Publication number: 20220120660Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first imaging apparatus, a second imaging apparatus, and a control device. The first imaging apparatus includes a first optical system and a first imaging element, and captures an image of the cell at a first position in a moving direction. The second imaging apparatus includes a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, and captures an image of the cell at a second position downstream of the first position. The control device obtains a passing position of the cell in a cross section of the flow path based on the image obtained by the first imaging element, generates the focus adjustment signal, and provides the signal to the second optical system.Type: ApplicationFiled: February 14, 2020Publication date: April 21, 2022Applicants: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.Inventors: Hirotoshi KIKUCHI, Hidenao YAMADA, Amane HIROTSU, Daisuke YAMASHITA, Shigetoshi OKAZAKI
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Patent number: 11285483Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.Type: GrantFiled: September 5, 2018Date of Patent: March 29, 2022Assignees: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Hirotoshi Kikuchi, Shigetoshi Okazaki, Hidenao Yamada, Yusuke Ozaki, Amane Hirotsu, Daisuke Yamashita
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Publication number: 20220067332Abstract: The method includes an acquisition step for model generation of acquiring a hologram for model generation in which an image of a cell is captured and which is used to generate a learning model, a generation step for model generation of generating a new hologram for model generation having a different focal position from the acquired hologram for model generation and increasing the number of holograms for model generation, and a learning model generation step of generating a learning model by performing machine learning using the increased holograms for model generation.Type: ApplicationFiled: August 24, 2021Publication date: March 3, 2022Applicant: Hamamatsu Photonics k.k.Inventors: Kibo OTE, Fumio HASHIMOTO, Osamu YASUHIKO, Hidenao YAMADA
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Patent number: 11204324Abstract: A fluorescence measurement apparatus includes a fluorescence image acquisition unit that acquires a fluorescence image containing an object, an interference image acquisition unit that acquires an interference image containing the object, and an operation unit. The operation unit determines an optical thickness image based on the interference image acquired by the interference image acquisition unit, and determines, in a region of interest set in common in both of the fluorescence image acquired by the fluorescence image acquisition unit and the optical thickness image, a fluorescence expression rate of the object based on an integrated value of a fluorescence intensity in the fluorescence image and an integrated value of an optical thickness in the optical thickness image.Type: GrantFiled: October 30, 2018Date of Patent: December 21, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko Yamauchi, Hidenao Yamada
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Patent number: 11156448Abstract: An interference observation apparatus includes a light source, a splitting beam splitter, a combining beam splitter, a mirror, a beam splitter, a mirror, a piezo element, a stage, a photodetector, an image acquisition unit, and a current control unit. An interference optical system from the splitting beam splitter to the combining beam splitter forms a Mach-Zehnder interferometer. The current control unit controls a wavelength of laser light output from the light source to adjust a phase difference between two split light components at the combining by the combining beam splitter.Type: GrantFiled: December 7, 2016Date of Patent: October 26, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko Yamauchi, Hidenao Yamada
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Publication number: 20210102235Abstract: An evaluation method is a method for evaluating a cell mass containing a plurality of aggregated cells, and includes an imaging step of capturing an image of light obtained from the cell mass by irradiating the cell mass with light, an analysis step of setting a reference point for the cell mass included in image data obtained by the imaging step, setting sampling circles centered on the reference point, and determining a parameter for a state of the cell mass based on image data included in regions on the sampling circles, and an evaluation step of evaluating the cell mass based on the parameter.Type: ApplicationFiled: March 13, 2018Publication date: April 8, 2021Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kentaro GOTO, Toyohiko YAMAUCHI, Hidenao YAMADA
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Publication number: 20200400562Abstract: An interference image acquisition apparatus includes a light source, a beam splitter, a second reflection mirror, an imager, and a first reflection mirror. A cell is placed on one side of a transparent material, and the first reflection mirror is placed on the other side of the transparent material. In a two-beam interferometer, an optical path difference between an optical path length of a first light beam reflected by the first reflection mirror and an optical path length of a second light beam reflected by the second reflection mirror is set to a coherence length of light output from the light source or less. The imager acquires an interference image in a state in which the cell is placed at a position conjugate to an imaging plane in a first optical system between the imaging plane and the first reflection mirror.Type: ApplicationFiled: November 22, 2018Publication date: December 24, 2020Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Toyohiko YAMAUCHI, Kentaro GOTO, Hisayuki MATSUI, Satoshi HIRAKAWA, Hidenao YAMADA
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Patent number: 10816319Abstract: A measurement apparatus includes an interference image acquisition unit, a fluorescence image acquisition unit, an operation unit, and a timing control circuit. The operation unit generates an optical thickness image based on an interference image acquired by the interference image acquisition unit, generates a mask image showing a region in which pixel values in a fluorescence image acquired by the fluorescence image acquisition unit are larger than a threshold value, and determines an integrated value of an optical thickness in the region shown by the mask image in the optical thickness image.Type: GrantFiled: September 5, 2019Date of Patent: October 27, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko Yamauchi, Osamu Yasuhiko, Hidenao Yamada, Hisayuki Matsui
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Publication number: 20200333250Abstract: A fluorescence measurement apparatus includes a fluorescence image acquisition unit that acquires a fluorescence image containing an object, an interference image acquisition unit that acquires an interference image containing the object, and an operation unit. The operation unit determines an optical thickness image based on the interference image acquired by the interference image acquisition unit, and determines, in a region of interest set in common in both of the fluorescence image acquired by the fluorescence image acquisition unit and the optical thickness image, a fluorescence expression rate of the object based on an integrated value of a fluorescence intensity in the fluorescence image and an integrated value of an optical thickness in the optical thickness image.Type: ApplicationFiled: October 30, 2018Publication date: October 22, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko YAMAUCHI, Hidenao YAMADA
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Publication number: 20200318942Abstract: Provided is an observation target cover for interference observation using first light and second light having a coherent length longer than that of the first light so as to acquire an interference light image of an observation target by the first light while adjusting an optical path length difference based on an interference result of the second light, the observation target cover including: a transmission reflection portion that transmits the first light and reflects the second light; and a support portion for supporting the transmission reflection portion so that a placement surface on which the observation target is placed and the transmission reflection portion face each other with a predetermined gap therebetween.Type: ApplicationFiled: October 11, 2018Publication date: October 8, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko YAMAUCHI, Hidenao YAMADA, Kentaro GOTO
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Publication number: 20200263972Abstract: An interference observation apparatus includes a light source, a splitting beam splitter, a combining beam splitter, a mirror, a beam splitter, a mirror, a piezo element, a stage, a photodetector, an image acquisition unit, and a current control unit. An interference optical system from the splitting beam splitter to the combining beam splitter forms a Mach-Zehnder interferometer. The current control unit controls a wavelength of laser light output from the light source to adjust a phase difference between two split light components at the combining by the combining beam splitter.Type: ApplicationFiled: December 7, 2016Publication date: August 20, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko YAMAUCHI, Hidenao YAMADA
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Publication number: 20200080833Abstract: A measurement apparatus includes an interference image acquisition unit, a fluorescence image acquisition unit, an operation unit, and a timing control circuit. The operation unit generates an optical thickness image based on an interference image acquired by the interference image acquisition unit, generates a mask image showing a region in which pixel values in a fluorescence image acquired by the fluorescence image acquisition unit are larger than a threshold value, and determines an integrated value of an optical thickness in the region shown by the mask image in the optical thickness image.Type: ApplicationFiled: September 5, 2019Publication date: March 12, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko YAMAUCHI, Osamu YASUHIKO, Hidenao YAMADA, Hisayuki MATSUI
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Patent number: D901714Type: GrantFiled: June 4, 2018Date of Patent: November 10, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko Yamauchi, Hidenao Yamada
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Patent number: D960389Type: GrantFiled: March 20, 2020Date of Patent: August 9, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Toyohiko Yamauchi, Hidenao Yamada