Abstract: The purpose of the present invention is to provide a novel therapeutic agent for liver disease. The present invention is a mesenchymal stem cell characterized by high expression of the Tissue Factor Pathway Inhibitor (TFPI). It is preferable that the mesenchymal stem cell is allogeneic and is derived from a fatty tissue. Moreover, the present invention includes a therapeutic agent for liver disease containing the mesenchymal stem cell.

Abstract: The purpose of the present invention is to provide a mesenchymal stem cell that is highly safe when used as a medicine. The present invention is a mesenchymal stem cell characterized in that the Tissue Factor (TF) is expressed at low levels. Furthermore, the present invention includes a mesenchymal stem cell characterized in that at least one integrin gene selected from the group consisting of ITGA11, ITGA1, ITGB5, ITGBL1, ITGB1 and ITGAV is expressed at low levels. Furthermore, the present invention includes a mesenchymal stem cell characterized in that at least one integrin gene selected from the group consisting of ITGA4, ITGA9, ITGA7, and ITGA10 is expressed at high levels. It is preferable that the mesenchymal stem cell is allogeneic and is derived from a fatty tissue. The present invention also includes a pharmaceutical composition containing the mesenchymal stem cell.

Abstract: The purpose of the present invention is to provide a novel therapeutic agent for liver disease. The present invention is a mesenchymal stem cell characterized by high expression of the Tissue Factor Pathway Inhibitor (TFPI). It is preferable that the mesenchymal stem cell is allogeneic and is derived from a fatty tissue. Moreover, the present invention includes a therapeutic agent for liver disease containing the mesenchymal stem cell.

Abstract: An object of the present invention is to provide a method for producing a therapeutic agent for liver diseases containing stromal cells derived from adipose tissue, which is excellent in convenience in preparation of a therapeutic agent while maintaining an excellent therapeutic effect on the stromal cells derived from adipose tissue against liver diseases, and a therapeutic agent for liver diseases obtained by such a producing method. The present invention is directed to a therapeutic agent for liver diseases containing stromal cells derived from adipose tissue which has been subjected to both cryopreservation and thawing at least twice.

Abstract: The present invention provides a solution increasing illuminance of the irradiation surface in a vicinity of the optical axis and suppressing the generation of the yellow ring phenomenon. The present invention is for a light emitting device 1 having a light emitting element 2 and a light control member 3, the light control member has a light incident surface 31 and light emitting surface 32, when the intersection point of the optical axis and a light emitting surface of the light emitting element 2 is defined as a base point, an angle formed by the optical axis and a line connecting the base point and an optional point is defined as ?1, and distance between the optional point of the light incident surface and the base point is defined as D1, for the light incident surface, the distance D1 is increasing as increasing the angle ?1 if the angle ?1 is 0??1<?1 (radian), and the distance D1 is decreasing as increasing the angle ?1 if ?1?2?1<(p/2) (radian).

Abstract: An optical lens having an incident surface on which the light emitted from a light emitting diode is incident and having a concave portion into which the light is received and an emitting surface emitting the light incident on the incident surface therethrough, the optical lens including: a plurality of refraction prevention portions protruded unitarily from the emitting surface to allow the light around a light axis emitted through the emitting surface to travel straight, without having any refraction, each refraction prevention portion having an orthogonal surface formed thereon to the advancing direction of the light incident through the incident surface.

Abstract: The present invention provides a solution increasing illuminance of the irradiation surface in a vicinity of the optical axis and suppressing the generation of the yellow ring phenomenon. The present invention is for a light emitting device 1 having a light emitting element 2 and a light control member 3, the light control member has a light incident surface 31 and light emitting surface 32, when the intersection point of the optical axis and a light emitting surface of the light emitting element 2 is defined as a base point, an angle formed by the optical axis and a line connecting the base point and an optional point is defined as ?1, and distance between the optional point of the light incident surface and the base point is defined as D1, for the light incident surface, the distance D1 is increasing as increasing the angle ?1 if the angle ?1 is 0??1<?1 (radian), and the distance D1 is decreasing as increasing the angle ?1 if ?1?2 ?1<(p/2) (radian).

Abstract: Disclosed is an optical lens having an incident surface on which the light emitted from a light emitting diode is incident and having a concave portion into which the light is received and an emitting surface emitting the light incident on the incident surface therethrough, the optical lens including: a plurality of refraction prevention portions protruded unitarily from the emitting surface to allow the light around a light axis emitted through the emitting surface to travel straight, without having any refraction, each refraction prevention portion having an orthogonal surface formed thereon to the advancing direction of the light incident through the incident surface.