Patents by Inventor Hidenori Ohki

Hidenori Ohki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8603975
    Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: December 10, 2013
    Assignee: Astellas Pharma Inc.
    Inventors: Toshio Yamanaka, Hidenori Ohki, Junya Ishida, Ayako Toda, Yu Harayama, Takuya Makino, Shigeki Kunikawa, Hiroaki Mizuno, Hiroaki Ohtake
  • Publication number: 20100120672
    Abstract: The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
    Type: Application
    Filed: April 25, 2008
    Publication date: May 13, 2010
    Inventors: Toshio Yamanaka, Hidenori Ohki, Junya Ishida, Ayako Toda, Yu Harayama, Takuya Makino, Shigeki Kunikawa, Hiroaki Mizuno, Hiroaki Ohtake
  • Publication number: 20090012054
    Abstract: The present invention provides a compound of the formula [I]: wherein R1 is lower alkyl, etc. and R2 is hydrogen, etc., or R1 and R2 are bonded together to form lower alkylene; R3 is a group represented by wherein R6 and R7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R8 and R9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R8 and R9, together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R4 is lower alkyl, etc.; and R5 is amino, etc., or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 16, 2007
    Publication date: January 8, 2009
    Applicants: ASTELLAS PHARMA INC., WAKUNAGA PHARMACEUTICAL CO. LTD.
    Inventors: Toshio Yamanaka, Ayako Toda, Hidenori Ohki, Shinya Okuda, Kohji Kawabata, Kenji Murano, Kazuo Hatano, Shinobu Takeda, Toru Nakai, Masaru Oogaki, Satoshi Inoue, Keiji Misumi, Kenji Itoh
  • Patent number: 7192943
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: March 20, 2007
    Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
  • Patent number: 7179801
    Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: February 20, 2007
    Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Hitomi Ogino, legal representative, Tetsuya Ogino, legal representative, Tomomi Takezawa, legal representative, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Hisashi Akamatsu, Kenji Satoh, Takashi Ogino, deceased
  • Publication number: 20070037786
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: October 24, 2006
    Publication date: February 15, 2007
    Applicants: WAKUNAGA PHARMACEUTICAL CO., LTD., Astellas Pharma Inc.
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Patent number: 7129232
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: October 31, 2006
    Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Publication number: 20050096306
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 17, 2004
    Publication date: May 5, 2005
    Applicants: Fujisawa Pharmaceutical Co. Ltd., Wakunaga Pharmaceutical Co., Ltd.
    Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
  • Patent number: 6884868
    Abstract: This invention relates to new polypeptide compound represented by general formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on ?-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: April 26, 2005
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takashi Tojo, Hidenori Ohki, Nobuyuki Shiraishi, Takahiro Matsuya, Hiroshi Matsuda, Kenji Murano, David Barrett, Takashi Ogino, Keiji Matsuda, Masaharu Ichihara, Norio Hashimoto, Atsushi Kanda, Atsushi Ohigashi
  • Publication number: 20050004094
    Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl which may have suitable substituent(s), R2 is amino, protected amino or guanidino, R3 is carboxy or protected carboxy, R4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 28, 2004
    Publication date: January 6, 2005
    Applicants: Fujisawa Pharmaceutical Co., Ltd., WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Toshio Yamanaka, Hidenori Ohki, Masaru Ohgaki, Shinya Okuda, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Publication number: 20040248875
    Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 9, 2004
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Takashi Ogino, Hitomi Ogino, Tetsuya Ogino, Tomomi Takezawa, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Hisashi Akamatsu, Kenji Satoh
  • Publication number: 20040132994
    Abstract: The present invention relates to a compound of the formula [I]: 1
    Type: Application
    Filed: October 30, 2003
    Publication date: July 8, 2004
    Applicants: Fujisawa Pharmaceutical Co., Ltd, WAKUNAGA PHARMACEUTICAL CO., LTD.
    Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
  • Patent number: 6743776
    Abstract: This invention relates to new polypeptide compounds represented by general formula [I]: wherein R1 and R2 are as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: June 1, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hidenori Ohki, Masaki Tomishima, Akira Yamada, Hisashi Takasugi
  • Publication number: 20040082757
    Abstract: This invention relates to new polypeptide compound represented by the following formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are described in the specification, or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Application
    Filed: August 25, 2003
    Publication date: April 29, 2004
    Inventors: Katsuhiko Ito, Yutaka Nishihara, Mitsutaka Matsurura, Kazumi Kawai, Masayoshi Kinoshita, Tomoji Higaki, Shigehiro Takase, Hidenori Ohki
  • Publication number: 20020193560
    Abstract: This invention relates to new polypeptide compounds represented by general formula (I), wherein R 1 and R 2 are as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially antifungal activities), inhibitory activity on &bgr; -1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia in a human being or an animal.
    Type: Application
    Filed: May 21, 1999
    Publication date: December 19, 2002
    Inventors: HIDENORI OHKI, MASAKI TOMISHIMA, AKIRA YAMADA, HISASHI TAKASUGI
  • Patent number: 6399567
    Abstract: This invention relates to new polypeptide compounds represented by the following formula (I): wherein R1 is as defined in the description or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g., Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: June 4, 2002
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Ryuichi Kanasaki, Shigehiro Takase, Michizane Hashimoto, Hiroshi Hatanaka, Kazutoshi Sakamoto, Seiji Hashimoto, Nobuyuki Shiraishi, Hidenori Ohki, Kohji Kawabata
  • Patent number: 6331521
    Abstract: The invention relates to new polypeptide compounds represented by the following formula [I]: wherein R1 is hydrogen, etc, R2 is hydrogen, etc, R3 is hydrogen, etc, and R4 is hydrogen, etc, or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: December 18, 2001
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Yasuhiro Hori, Yasuhisa Tsurumi, Shigehiro Takase, Hiroshi Hatanaka, Kazutoshi Sakamoto, Seiji Hashimoto, Hidenori Ohki, Takashi Tojo, Keiji Matsuda, Kohji Kawabata
  • Patent number: 6265536
    Abstract: This invention relates to new polypeptide compounds represented by the following formula (I): wherein R1 is as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: July 24, 2001
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hidenori Ohki, Masaki Tomishima, Akira Yamada, Hisashi Takasugi
  • Patent number: 6232290
    Abstract: This invention relates to new polypeptide compounds represented by general formula (I), wherein R1, R2, R3 and R4 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: May 15, 2001
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hidenori Ohki, Kenji Murano, Takashi Tojo, Nobuyuki Shiraishi, Takahiro Matsuya, Hiroshi Matsuda, Hiroaki Mizuno, David Barrett, Keiji Matsuda, Kohji Kawabata
  • Patent number: 6107458
    Abstract: This invention relates to new polypeptide compounds represented by the following formula (I): ##STR1## wherein R.sup.1 is as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on .beta.-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: August 22, 2000
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hidenori Ohki, Masaki Tomishima, Akira Yamada, Hisashi Takasugi