Abstract: A mass spectrometry method in which a precursor ion is introduced into a reaction chamber (step 2), a radical is generated in a radical generation chamber, the precursor ion is irradiated with the radical to generate a product ion (step 15), and a mass of the product ion is measured (step 16) includes, when generating the radical, introducing a material gas into the radical generation chamber (steps 5 and 8), supplying radio-frequency power to the material gas simultaneously with or after introducing the precursor ion into the reaction chamber (steps 5 and 8), and supplying an electron to the material gas in a state where the radio-frequency power is supplied to generate plasma emission, and irradiating the material gas with the plasma emission to generate the radical (steps 6 and 9).

Abstract: To provide an information processing apparatus, an information processing method, and a computer-readable recording medium that can infer one or more diseases from a medical image. An image acquisition unit 225 that acquires a medical image, an image feature extraction unit 227 that extracts one or more image feature values from the medical image, an inference unit 226 that infers one or more diseases predicted from the medical image based on the one or more image feature values and a classification basis 233, the classification basis being a set of basis vectors that represent correlations between each of the diseases and other diseases by using a vector of a certain dimension, and an output unit 228 that outputs results inferred by the inference unit are included.

Abstract: An ion analyzer for analyzing product ions generated by irradiating precursor ions derived from a sample component with radicals, the ion analyzer including a reaction chamber 2, a radical supply unit 5, 6 configured to generate radicals and supply the radicals to the reaction chamber, a radical temperature acquisition unit 911, 912 configured to acquire a temperature of the radicals to be supplied to the reaction chamber, a standard substance supply unit 11 configured to supply a predetermined amount of predetermined precursor ions to the reaction chamber, the predetermined precursor ions being generated from a standard substance whose activation energy of a reaction in which the radicals attach to the standard substance is known, an ion measurement unit 92 configured to measure an amount of predetermined product ions generated from the precursor ions derived from the standard substance by the reaction with the radicals, a reactive radical amount calculation unit 93 configured to obtain an amount of reactive

Abstract: SPINK2 mutant peptide conjugates are provided that inhibit KLK5. The KLK5 inhibitory peptide conjugates are Fc fusion peptides in which, in certain embodiments, the Fc region of the fusion peptides are the Fc region of human IgG1 or a fragment thereof. The KLK5 inhibitory peptide conjugates include an amino acid sequence of one of SEQ ID NOs: 34, 36, 38, 40, 42, 44, 46, 48, 96, 50, 52, 54, 56, 58, or 60. Pharmaceutical compositions that include the KLK5 inhibitory peptide conjugates useful for treating KLK5-related diseases are also provided.

Abstract: In a method for analyzing isoaspartic acid by dissociating precursor ions derived from a sample component and generating and analyzing product ions, the method includes: generating product ions by irradiating the precursor ions with hydrogen radicals or radicals having oxidizing ability to dissociate the precursor ions; separating and detecting the product ions according to a mass-to-charge ratio; and specifying product ions derived from isoaspartic acid based on a mass-to-charge ratio of the product ions.

Abstract: The precursor ion is reacted with ammonia molecules or ammonia radicals to generate product ions, the product ions are separated according to a mass-to-charge ratio, and detected. It is estimated that whether or not an aldehyde group is included in a molecular structure of the precursor ion based on a difference between a mass-to-charge ratio of one of the detected product ion and a mass-to-charge ratio of the precursor ion. In addition, provided is a mass spectrometer (1) including: a reaction chamber (132) to which the precursor ions are introduced; an ammonia supply part (5) configured to supply ammonia molecules or ammonia radicals to the reaction chamber; and separation and detection parts (142, 143, 144, and 145) configured to separate product ions generated from the precursor ion by reaction with the ammonia molecules or ammonia radicals according to a mass-to-charge ratio, and to detect the product ions.

Abstract: A communication device includes: a switching unit connected to a transmission unit, a reception unit, a transmission port, and a reception port, the switching unit being set in a first state in which the transmission unit and the transmission port are connected and the reception unit and the reception port are connected or a second state in which the transmission unit and the reception port are connected and the reception unit and the transmission port are connected; a monitoring unit configured to monitor a light level of light input from the reception port or the transmission port; and a control unit configured to set the switching unit in the first state or the second state based on the light level monitored by the monitoring unit.

Abstract: First product ion spectrum data is acquired by dissociating a precursor ion derived from a sample component by collision between the precursor ion and an inert gas molecule to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; second product ion spectrum data is acquired by dissociating the precursor ion by a reaction of the precursor ion with hydrogen radicals to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; and a set of product ions having a predetermined mass difference is extracted in the first product ion spectrum data and the second product ion spectrum data.

Abstract: An ion analyzer includes a reaction chamber into which precursor ions derived from a sample component are introduced, a radical irradiation unit that generates and emits a predetermined type of radicals, a standard substance supply unit that individually supplies kinds of standard substances to the reaction chamber, where activation energy of radical addition reaction is known for each of the kinds of standard substances, and the activation energies are different in magnitude, an ion measurement unit that measures an amount of predetermined product ions generated from precursor ions derived from the standard substance by irradiation with the radicals, and a radical temperature calculation unit that obtains an amount of radicals that caused the radical addition reaction from the amount of the predetermined product ions and obtains a radical temperature based on a relationship between the amount of the radicals obtained for each kind of standard substance and activation energy.

Abstract: Provided is a mass spectrometer including: a reaction chamber (132) into which a precursor ion is introduced; a radical generation part (54) configured to generate a known radical; a radical supply part (5) configured to react the precursor ion with the radical to generate fragment ions and an adduct ion; a measurement control part (63) configured to measure ions including the precursor ion, the fragment ions, and the adduct ion to obtain a mass spectrum; and an accurate mass estimation part (64) configured to specify a peak of the adduct ion by searching a predetermined mass range centered on a mass value obtained by adding a mass of an atom or molecule derived from the radical to a mass obtained from a peak of the precursor ion, and estimate an accurate mass of the precursor ion by subtracting an accurate mass of the atom or molecule from an accurate mass of the peak.

Abstract: A mass spectrometer including: a reaction chamber into which a precursor ion derived from a sample molecule is introduced; a collision gas supply part configured to supply collision gas to the reaction chamber; a radical supply part configured to supply hydrogen radicals, oxygen radicals, nitrogen radicals, or hydroxyl radicals to the reaction chamber; a dissociation operation control part configured to control operations of the collision gas supply part and the radical supply part to generate the product ions by collision-induced dissociation and radical attachment dissociation of the precursor ion inside the reaction chamber, an ion detection part configured to mass-separate and detect ions ejected from the reaction chamber, and a spectrum data generation part configured to generate spectrum data based on a detection result by the ion detection part.

Abstract: Provided is an ion analysis device (10) that irradiates sample component-derived precursor ions with radicals so as to generate product ions and analyzes the product ions, said device comprising: a reaction chamber (142) into which the precursor ions are introduced; a radical generation unit (151) which generates radicals; and a radical transport pipe (152) which connects the radical generation unit (151) and the reaction chamber (142), wherein at least part of the inner wall surface of the radical transport pipe (152) is made of a material having a lesser amount of or lower strength of radical adherence to the inner wall surface of the radical transport pipe (152) in comparison with alumina or quartz. One end (1523) of the radical transport pipe (152) is disposed inside the reaction chamber (142) and preferably faces toward a prescribed region (1424) where ions are localized in the reaction chamber (142).

Abstract: A mass spectrometer 1, which is for generating a product ion from a precursor ion derived from a sample component having a hydrocarbon chain to analyze a mass, includes a reaction chamber 2 into which the precursor ion is introduced, radical generating units 51, 52, and 53 that generate a radical having an oxidizing ability or/and a radical other than a hydrogen radical having a reducing ability, a radical irradiation unit 54 that irradiates the inside of the reaction chamber 2 with the generated radical, a separation detection unit 3 that separates and detects the product ion generated from the precursor ion by a reaction with the radical according to a mass-to-charge ratio, and a structure estimation unit 14 that estimates the structure of the sample component based on the mass-to-charge ratio of the detected product ions and the information on the structure or the structure candidate.

Abstract: A prognosis determination device including an acquisition unit that acquires a medical image and a biological parameter that are related to a disease of a subject; and an output unit that inputs, to a discriminator, information on the medical image, information on the biological parameter, and information on treatment to be performed, and causes the discriminator to output information on a prognosis for a case where the treatment is performed, in which the discriminator has been generated through a machine learning process based on actual treatment data and interpolation treatment data, the actual treatment data is data on the treatment that has been actually performed, the actual treatment data including a pretreatment medical image as well as a pretreatment biological parameter of a patient, information on the treatment performed on the patient, and information on a prognosis for the patient after the treatment, and the interpolation treatment data is information for interpolating a posttreatment prognosis

Abstract: Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.

Abstract: An ion analyzer that generates and analyzes product ions by irradiating precursor ions derived from a sample component with radicals, the ion analyzer including: a reaction chamber (2; 833) into which the precursor ions are introduced; a radical generation unit (5) configured to generate radicals from a first material gas; a metastable particle generation unit (5) configured to generate metastable particles from a second material gas; a radical introduction unit (5) configured to mix the radical and the metastable particles and introduce the mixture into the reaction chamber (2; 833); and an ion detection unit (4; 835) configured to detect product ions generated from the precursor ions by a reaction with the radicals.

Abstract: Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.

Abstract: A connector that connects a first multi-core optical fiber to which a first plug is provided and a second multi-core optical fiber to which a second plug is provided to one another, includes: a first jack for inserting the first plug; and a second jack for inserting the second plug, wherein the first jack is configured so that the first plug in a first state and the first plug in a second state can at least be inserted thereinto, and the first plug in the second state is obtained by rotating the first plug in the first state by 180 degrees about an insertion direction as the axis of rotation, the insertion direction being the direction in which the first plug is inserted into the first jack.

Abstract: Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.

Abstract: The invention related to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R2, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.