Patents by Inventor Hidenori Takahashi

Hidenori Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11908671
    Abstract: An ion analyzer includes a reaction chamber into which precursor ions derived from a sample component are introduced, a radical irradiation unit that generates and emits a predetermined type of radicals, a standard substance supply unit that individually supplies kinds of standard substances to the reaction chamber, where activation energy of radical addition reaction is known for each of the kinds of standard substances, and the activation energies are different in magnitude, an ion measurement unit that measures an amount of predetermined product ions generated from precursor ions derived from the standard substance by irradiation with the radicals, and a radical temperature calculation unit that obtains an amount of radicals that caused the radical addition reaction from the amount of the predetermined product ions and obtains a radical temperature based on a relationship between the amount of the radicals obtained for each kind of standard substance and activation energy.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: February 20, 2024
    Assignees: SHIMADZU CORPORATION, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hidenori Takahashi, Daiki Asakawa
  • Publication number: 20240038515
    Abstract: Provided is a mass spectrometer including: a reaction chamber (132) into which a precursor ion is introduced; a radical generation part (54) configured to generate a known radical; a radical supply part (5) configured to react the precursor ion with the radical to generate fragment ions and an adduct ion; a measurement control part (63) configured to measure ions including the precursor ion, the fragment ions, and the adduct ion to obtain a mass spectrum; and an accurate mass estimation part (64) configured to specify a peak of the adduct ion by searching a predetermined mass range centered on a mass value obtained by adding a mass of an atom or molecule derived from the radical to a mass obtained from a peak of the precursor ion, and estimate an accurate mass of the precursor ion by subtracting an accurate mass of the atom or molecule from an accurate mass of the peak.
    Type: Application
    Filed: December 23, 2021
    Publication date: February 1, 2024
    Applicant: SHIMADZU CORPORATION
    Inventors: Kazutaka MITSUI, Hidenori TAKAHASHI
  • Publication number: 20240030016
    Abstract: A mass spectrometer including: a reaction chamber into which a precursor ion derived from a sample molecule is introduced; a collision gas supply part configured to supply collision gas to the reaction chamber; a radical supply part configured to supply hydrogen radicals, oxygen radicals, nitrogen radicals, or hydroxyl radicals to the reaction chamber; a dissociation operation control part configured to control operations of the collision gas supply part and the radical supply part to generate the product ions by collision-induced dissociation and radical attachment dissociation of the precursor ion inside the reaction chamber, an ion detection part configured to mass-separate and detect ions ejected from the reaction chamber, and a spectrum data generation part configured to generate spectrum data based on a detection result by the ion detection part.
    Type: Application
    Filed: July 30, 2021
    Publication date: January 25, 2024
    Applicant: SHIMADZU CORPORATION
    Inventors: Hidenori TAKAHASHI, Shinichi YAMAGUCHI
  • Publication number: 20230386814
    Abstract: Provided is an ion analysis device (10) that irradiates sample component-derived precursor ions with radicals so as to generate product ions and analyzes the product ions, said device comprising: a reaction chamber (142) into which the precursor ions are introduced; a radical generation unit (151) which generates radicals; and a radical transport pipe (152) which connects the radical generation unit (151) and the reaction chamber (142), wherein at least part of the inner wall surface of the radical transport pipe (152) is made of a material having a lesser amount of or lower strength of radical adherence to the inner wall surface of the radical transport pipe (152) in comparison with alumina or quartz. One end (1523) of the radical transport pipe (152) is disposed inside the reaction chamber (142) and preferably faces toward a prescribed region (1424) where ions are localized in the reaction chamber (142).
    Type: Application
    Filed: September 28, 2021
    Publication date: November 30, 2023
    Applicant: SHIMADZU CORPORATION
    Inventors: Masaji FURUTA, Hidenori TAKAHASHI
  • Patent number: 11804369
    Abstract: A mass spectrometer 1, which is for generating a product ion from a precursor ion derived from a sample component having a hydrocarbon chain to analyze a mass, includes a reaction chamber 2 into which the precursor ion is introduced, radical generating units 51, 52, and 53 that generate a radical having an oxidizing ability or/and a radical other than a hydrogen radical having a reducing ability, a radical irradiation unit 54 that irradiates the inside of the reaction chamber 2 with the generated radical, a separation detection unit 3 that separates and detects the product ion generated from the precursor ion by a reaction with the radical according to a mass-to-charge ratio, and a structure estimation unit 14 that estimates the structure of the sample component based on the mass-to-charge ratio of the detected product ions and the information on the structure or the structure candidate.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: October 31, 2023
    Assignee: SHIMADZU CORPORATION
    Inventor: Hidenori Takahashi
  • Publication number: 20230317283
    Abstract: A prognosis determination device including an acquisition unit that acquires a medical image and a biological parameter that are related to a disease of a subject; and an output unit that inputs, to a discriminator, information on the medical image, information on the biological parameter, and information on treatment to be performed, and causes the discriminator to output information on a prognosis for a case where the treatment is performed, in which the discriminator has been generated through a machine learning process based on actual treatment data and interpolation treatment data, the actual treatment data is data on the treatment that has been actually performed, the actual treatment data including a pretreatment medical image as well as a pretreatment biological parameter of a patient, information on the treatment performed on the patient, and information on a prognosis for the patient after the treatment, and the interpolation treatment data is information for interpolating a posttreatment prognosis
    Type: Application
    Filed: July 15, 2021
    Publication date: October 5, 2023
    Inventor: Hidenori TAKAHASHI
  • Publication number: 20230271952
    Abstract: Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.
    Type: Application
    Filed: May 5, 2023
    Publication date: August 31, 2023
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Akito KAKUUCHI, Shuhei UMEMURA, Masaki ASADA, Anatoly RUVINSKY, Yan ZHANG, Hidenori TAKAHASHI, Goran KRILOV, Daigo INOYAMA, Kyle KONZE, Mats SVENSSON
  • Patent number: 11735408
    Abstract: An ion analyzer that generates and analyzes product ions by irradiating precursor ions derived from a sample component with radicals, the ion analyzer including: a reaction chamber (2; 833) into which the precursor ions are introduced; a radical generation unit (5) configured to generate radicals from a first material gas; a metastable particle generation unit (5) configured to generate metastable particles from a second material gas; a radical introduction unit (5) configured to mix the radical and the metastable particles and introduce the mixture into the reaction chamber (2; 833); and an ion detection unit (4; 835) configured to detect product ions generated from the precursor ions by a reaction with the radicals.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 22, 2023
    Assignee: SHIMADZU CORPORATION
    Inventor: Hidenori Takahashi
  • Patent number: 11691968
    Abstract: Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: July 4, 2023
    Assignee: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Akito Kakuuchi, Shuhei Umemura, Masaki Asada, Anatoly Ruvinsky, Yan Zhang, Hidenori Takahashi, Goran Krilov, Daigo Inoyama, Kyle Konze, Mats Svensson
  • Publication number: 20230204871
    Abstract: A connector that connects a first multi-core optical fiber to which a first plug is provided and a second multi-core optical fiber to which a second plug is provided to one another, includes: a first jack for inserting the first plug; and a second jack for inserting the second plug, wherein the first jack is configured so that the first plug in a first state and the first plug in a second state can at least be inserted thereinto, and the first plug in the second state is obtained by rotating the first plug in the first state by 180 degrees about an insertion direction as the axis of rotation, the insertion direction being the direction in which the first plug is inserted into the first jack.
    Type: Application
    Filed: February 28, 2023
    Publication date: June 29, 2023
    Inventors: Hidenori TAKAHASHI, Daiki SOMA, Noboru YOSHIKANE, Takehiro TSURITANI
  • Publication number: 20230109293
    Abstract: Disclosed are compounds of following formula (I): in which all symbols have the same meanings as the definitions described in the specification; or a salt thereof. The compounds or a salt thereof are useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, Alzheimer's disease and the like.
    Type: Application
    Filed: October 24, 2022
    Publication date: April 6, 2023
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Akito KAKUUCHI, Shuhei UMEMURA, Masaki ASADA, Anatoly RUVINSKY, Yan ZHANG, Hidenori TAKAHASHI, Goran KRILOV, Daigo INOYAMA, Kyle KONZE, Mats SVENSSON
  • Patent number: 11597009
    Abstract: Provided are an alloy powder having excellent environmental resistance even in an environment where corrosion and wear are active simultaneously, and an alloy coating using the powder. A Ni—Fe base alloy powder comprising Cr of 15% by mass or more and 35% by mass or less, Fe of 10% by mass or more and 50% by mass or less, Mo of 0% by mass or more and 5% by mass or less, Si of 0.3% by mass or more and 2% by mass or less, C of 0.3% by mass or more and 0.9% by mass or less, B of 4% by mass or more and 7% by mass or less, and a balance of Ni and incidental impurities.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: March 7, 2023
    Assignees: Ebara Corporation, Ebara Environmental Plant Co., Ltd., Dai-Ichi High Frequency Co., Ltd.
    Inventors: Manabu Noguchi, Eiji Ishikawa, Eichi Tanaka, Shigenari Hayashi, Takashi Kogin, Nobuhiro Takasaki, Kenichiro Okutsu, Masaya Kanazawa, Yasuki Miyakoshi, Hidenori Takahashi, Suzue Yoneda, Takayuki Saitou
  • Publication number: 20230048972
    Abstract: An ion analysis device 1 configured to generate and analyze product ions from precursor ions derived from a sample component includes: a reaction chamber 132 into which the precursor ions are introduced; a radical emitter 134 made of a predetermined kind of metal and disposed in the reaction chamber or a space communicating with the reaction chamber, at least a part of a surface of the radical emitter being oxidized or nitrided; a heating unit 20 configured to heat the radical emitter to a predetermined temperature; and separation detection units 135 and 136 configured to separate and detect, according to at least one of a mass-to-charge ratio and an ion mobility, product ions generated from the precursor ions by a reaction with radicals emitted from the radical emitter heated to the predetermined temperature.
    Type: Application
    Filed: March 12, 2020
    Publication date: February 16, 2023
    Applicant: SHIMADZU CORPORATION
    Inventor: Hidenori TAKAHASHI
  • Publication number: 20230038133
    Abstract: An optical fiber amplification. system includes: a first optical fiber amplifier including a first optical amplifying fiber including a core portion doped with a first rare-earth. element, a first input unit configured to receive first signal light, an excitation-light source configured to output pump light, a pump light combiner configured to input the pump light to the first optical amplifying fiber, and a residual pump light recovery device configured to recover residual pump light; and a second optical fiber amplifier including a second optical amplifying fiber including a core portion doped with a second rare-earth. element, a second input unit configured to receive second signal light, and a residual pump light combiner configured to input, to the second optical amplifying fiber, the residual pump light recovered by the residual pump light recovery device.
    Type: Application
    Filed: September 29, 2022
    Publication date: February 9, 2023
    Applicants: FURUKAWA ELECTRIC CO., LTD., KDDI CORPORATION
    Inventors: Shigehiro TAKASAKA, Koichi MAEDA, Ryuichi SUGIZAKI, Takehiro TSURITANI, Hidenori TAKAHASHI, Itsuro MORITA
  • Patent number: 11532737
    Abstract: A semiconductor device is provided, wherein a semiconductor substrate includes: a first trench portion provided from a front surface of the semiconductor substrate to a predetermined depth, and having a longer portion and a shorter portion as seen from above; and a first conductivity-type floating semiconductor region at least partially exposed on the front surface and surrounded by the first trench portion, an interlayer insulating film has openings to electrically connect an emitter electrode and the floating semiconductor region, the openings include: a first opening closest to an outer end of the floating semiconductor region in a direction parallel to the longer portion; and a second opening second closest to the outer end in the direction parallel to the longer portion, and a distance between the first opening and the second opening is shorter than a distance between any adjacent two of the openings other than the first opening.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: December 20, 2022
    Assignee: FUJI ELECTRIC CO., LTD.
    Inventors: Yoshiharu Kato, Hidenori Takahashi, Tatsuya Naito
  • Publication number: 20220344140
    Abstract: An ion analyzer includes: a reaction chamber 2 into which precursor ions derived from a sample component are introduced; a radical generation unit including an insulating tube 551, and a discharge unit 54, 552 configured to generate a discharge inside the insulating tube; a gas supply unit 52, 53 capable of supplying a first gas which is a radical raw material gas, and a second gas which is any of an oxygen gas, an ozone gas, a nitrogen gas, a gas of a compound containing an oxygen atom or a nitrogen atom, and a rare gas to an inside of the insulating tube; an evacuation unit 57 configured to evacuate the inside of the insulating tube; a radical introduction unit 55 configured to introduce radicals into an inside of the reaction chamber; and a control unit 93 configured to perform a first operation of introducing the first gas into the inside of the insulating tube, generating radicals by generating a discharge, and introducing the radicals into the inside of the reaction chamber, and a second operation of in
    Type: Application
    Filed: April 13, 2020
    Publication date: October 27, 2022
    Applicant: SHIMADZU CORPORATION
    Inventors: Hidenori TAKAHASHI, Koichi TANAKA
  • Publication number: 20220306725
    Abstract: SPINK2 mutant peptide conjugates are provided that inhibit KLK5. The KLK5 inhibitory peptide conjugates are Fc fusion peptides in which, in certain embodiments, the Fc region of the fusion peptides are the Fc region of human IgG1 or a fragment thereof. The KLK5 inhibitory peptide conjugates include an amino acid sequence of one of SEQ ID NOs: 34, 36, 38, 40, 42, 44, 46, 48, 96, 50, 52, 54, 56, 58, or 60. Pharmaceutical compositions that include the KLK5 inhibitory peptide conjugates useful for treating KLK5-related diseases are also provided.
    Type: Application
    Filed: March 29, 2022
    Publication date: September 29, 2022
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Daisuke Nishimiya, Hidenori Yano, Hidenori Takahashi, Shinji Yamaguchi, Shiho Ofuchi
  • Publication number: 20220289751
    Abstract: The compound disclosed is a KDM5 inhibitor represented by the general formula (Z): wherein all symbols have the same meanings as the definitions described in the specification, or a salt thereof, and is useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, or Alzheimer's disease and the like.
    Type: Application
    Filed: July 16, 2020
    Publication date: September 15, 2022
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Akito KAKUUCHI, Shuhei UMEMURA, Mats SVENSSON, Anatoly RUVINSKY, Daigo INOYAMA, Goran KRILOV, Hidenori TAKAHASHI, Kyle KONZE, Andreas VERRAS, Simon CRUMPLER, Maelle VALLADE, Calum MACLEOD, James N. SANDERSON, Richard J. BULL, Simon GAINES
  • Publication number: 20220260527
    Abstract: An ion analyzer for analyzing product ions generated by irradiating precursor ions derived from a sample component with radicals, the ion analyzer including a reaction chamber 2, a radical supply unit 5, 6 configured to generate radicals and supply the radicals to the reaction chamber, a radical temperature acquisition unit 911, 912 configured to acquire a temperature of the radicals to be supplied to the reaction chamber, a standard substance supply unit 11 configured to supply a predetermined amount of predetermined precursor ions to the reaction chamber, the predetermined precursor ions being generated from a standard substance whose activation energy of a reaction in which the radicals attach to the standard substance is known, an ion measurement unit 92 configured to measure an amount of predetermined product ions generated from the precursor ions derived from the standard substance by the reaction with the radicals, a reactive radical amount calculation unit 93 configured to obtain an amount of reactive
    Type: Application
    Filed: July 19, 2019
    Publication date: August 18, 2022
    Applicants: Shimadzu Corporation, National Institute of Advanced Industrial Science and Technology
    Inventors: Hidenori TAKAHASHI, Daiki ASAKAWA
  • Patent number: RE49699
    Abstract: The invention related to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R2, A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 17, 2023
    Assignees: Boehringer Ingelheim International GmbH, Hydra Biosciences, LLC
    Inventors: Thierry Bouyssou, Dirk Gottschling, Niklas Heine, Lana Louise Smith Keenan, Michael D. Lowe, Hossein Razavi, Christopher Ronald Sarko, Simon Surprenant, Hidenori Takahashi, Michael Robert Turner, Xinyuan Wu