Patents by Inventor Hideo Akiyama

Hideo Akiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11851646
    Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: December 26, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
  • Patent number: 10647978
    Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: May 12, 2020
    Assignee: Toray Industries, Inc.
    Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
  • Publication number: 20180340166
    Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 29, 2018
    Applicant: Toray Industries, Inc.
    Inventors: MAKIKO YOSHIMOTO, Hideo Akiyama, Hitoshi Nobumasa
  • Publication number: 20170247681
    Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 31, 2017
    Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
  • Patent number: 8945849
    Abstract: This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: February 3, 2015
    Assignees: Toray Industries, Inc., Kyoto University
    Inventors: Akira Myomoto, Satoko Kozono, Hideo Akiyama, Hitoshi Nobumasa, Yutaka Shimada, Gozoh Tsujimoto
  • Publication number: 20130144049
    Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.
    Type: Application
    Filed: August 17, 2011
    Publication date: June 6, 2013
    Applicant: Toray Industries, Inc.
    Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
  • Patent number: 8198025
    Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: June 12, 2012
    Assignees: Toray Industries, Inc., Kyoto University
    Inventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
  • Publication number: 20110201520
    Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 18, 2011
    Applicants: TORAY INDUSTRIES, INC., Kyoto University
    Inventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
  • Publication number: 20110098185
    Abstract: This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.
    Type: Application
    Filed: May 21, 2009
    Publication date: April 28, 2011
    Inventors: Akira Myomoto, Satoko Kozono, Hideo Akiyama, Hitoshi Nobumasa, Yutaka Shimada, Gozoh Tsujimoto
  • Patent number: 7932032
    Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: April 26, 2011
    Assignees: Toray Industries, Inc., Kyoto University
    Inventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
  • Patent number: 7910316
    Abstract: This invention relates to a method for detecting in vitro a urothelial cancer, comprising measuring CXCL1 protein, or expression of a gene encoding the protein, in a biological sample from a subject, and to a kit for diagnosing a urothelial cancer comprising an antibody or nucleic acid probe, which is capable of binding specifically to the CXCL1 protein or a gene encoding the protein, respectively.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: March 22, 2011
    Assignees: Toray Industries, Inc., Kyoto University
    Inventors: Hideo Akiyama, Yoshinori Tanaka, Satoko Kozono, Hitoshi Nobumasa, Osamu Ogawa, Takeshi Takahashi
  • Publication number: 20100152055
    Abstract: This invention relates to a composition, kit, DNA chip, and use thereof for detecting, diagnosing, and predicting metastasis of kidney cancer and/or for predicting the prognosis for kidney cancer, comprising one or a plurality of polynucleotides selected from the group consisting of polynucleotides, mutants thereof or fragments thereof, the expression levels of which vary in kidney cancer cells from a patient with a poor prognosis when compared with that in kidney cancer cells from a patient with a good prognosis; or antibodies or fragments thereof that bind specifically to polypeptides, mutants thereof or fragments thereof, the expression levels of which vary in the similar manner.
    Type: Application
    Filed: September 1, 2006
    Publication date: June 17, 2010
    Inventors: Satoko Kozono, Hideo Akiyama, Akira Myomoto, Yoshinori Tanaka, Giman Jung, Hitoshi Nobumasa, Osamu Nomura, Osamu Ogawa, Eijiro Nakamura, Gozo Tsujimoto
  • Publication number: 20100009347
    Abstract: This invention relates to a method for detecting in vitro a urothelial cancer, comprising measuring CXCL1 protein, or expression of a gene encoding the protein, in a biological sample from a subject, and to a kit for diagnosing a urothelial cancer comprising an antibody or nucleic acid probe, which is capable of binding specifically to the CXCL1 protein or a gene encoding the protein, respectively.
    Type: Application
    Filed: September 1, 2006
    Publication date: January 14, 2010
    Inventors: Hideo Akiyama, Yoshinori Tanaka, Satoko Kozono, Hitoshi Nobumasa, Osamu Ogawa, Takeshi Takahashi
  • Publication number: 20090270267
    Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.
    Type: Application
    Filed: May 2, 2006
    Publication date: October 29, 2009
    Applicants: TORAY INDUSTRIES, INC., Kyoto University
    Inventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
  • Publication number: 20070218453
    Abstract: This invention relates to a hollow-nanoparticle-based biosensing tool, which comprises proteins capable of forming nanoparticles through the incorporation of a lipid bilayer and specific biorecognition molecules bound thereto and a biosensing method using such tool.
    Type: Application
    Filed: March 29, 2005
    Publication date: September 20, 2007
    Inventors: Katsuyuki Tanizawa, Shun'ichi Kuroda, Giman Jung, Hideo Akiyama, Hitoshi Nobumasa
  • Patent number: 5977490
    Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 /g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique.The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.
    Type: Grant
    Filed: January 8, 1997
    Date of Patent: November 2, 1999
    Assignees: Matsushita Electric Industrial Co., Ltd., Dai-Ichi Kogyo Seiyaku Co. Ltd., Dowa Mining Co., Ltd.
    Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
  • Patent number: 5914358
    Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 /g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.multidot.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.multidot.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique.The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: June 22, 1999
    Assignees: Matsushita Electric Industrial Co., Ltd., Dai-ichi Kogyo Seiyaku Co., Ltd., Dowa Mining Co., Ltd.
    Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
  • Patent number: 5733467
    Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 / g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique. The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: March 31, 1998
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
  • Patent number: 5652042
    Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 /g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.multidot.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.multidot.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique.The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: July 29, 1997
    Assignees: Matsushita Electric Industrial Co., Ltd., Dai-Ichi Kogyo Seiyaku Co., Ltd., Dowa Mining Co., Ltd.
    Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
  • Patent number: 4686328
    Abstract: A hermetically sealed connector for a glove box and a method for exchanging such connectors in which leakage of radioactive material from within the glove box is minimized and an auxiliary glove box is not needed to exchange the connectors. The connector is formed as a cylindrical member having a flange portion hermetically sealed to a packing provided in a through hole in the wall of the glove box. To exchange connectors, a nut is removed from the outer end of the old connector and a tube is screwed thereto. The other end of the tube is fitted to the inner end of the new connector. The tube is then shoved through the packing until the flange of the new connector aligns with the packing. The tube is then removed from the inner end of the new connector and a nut is screwed on in replacement for the tube.
    Type: Grant
    Filed: April 20, 1984
    Date of Patent: August 11, 1987
    Assignees: Doryokuro Kakunenryo Kaihatsu Jigyodan, Hitachi Cable Ltd.
    Inventors: Masahito Ui, Hideo Akiyama, Akio Todokoro, Yukio Natsui, Hiroshi Kogure, Yujiro Kato, Tsuneo Ozaki