Patents by Inventor Hideo Akiyama
Hideo Akiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11851646Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.Type: GrantFiled: July 30, 2018Date of Patent: December 26, 2023Assignee: Toray Industries, Inc.Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
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Patent number: 10647978Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.Type: GrantFiled: April 28, 2017Date of Patent: May 12, 2020Assignee: Toray Industries, Inc.Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
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Publication number: 20180340166Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.Type: ApplicationFiled: July 30, 2018Publication date: November 29, 2018Applicant: Toray Industries, Inc.Inventors: MAKIKO YOSHIMOTO, Hideo Akiyama, Hitoshi Nobumasa
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Publication number: 20170247681Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.Type: ApplicationFiled: April 28, 2017Publication date: August 31, 2017Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
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Patent number: 8945849Abstract: This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.Type: GrantFiled: May 21, 2009Date of Patent: February 3, 2015Assignees: Toray Industries, Inc., Kyoto UniversityInventors: Akira Myomoto, Satoko Kozono, Hideo Akiyama, Hitoshi Nobumasa, Yutaka Shimada, Gozoh Tsujimoto
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Publication number: 20130144049Abstract: A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises: (a) phenol in an amount of more than 50% by volume based on the total amount of the solution; (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution; (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution; (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and (e) a buffer for maintaining the pH of the solution at 4 to 6.Type: ApplicationFiled: August 17, 2011Publication date: June 6, 2013Applicant: Toray Industries, Inc.Inventors: Makiko Yoshimoto, Hideo Akiyama, Hitoshi Nobumasa
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Patent number: 8198025Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.Type: GrantFiled: April 6, 2011Date of Patent: June 12, 2012Assignees: Toray Industries, Inc., Kyoto UniversityInventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
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Publication number: 20110201520Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.Type: ApplicationFiled: April 6, 2011Publication date: August 18, 2011Applicants: TORAY INDUSTRIES, INC., Kyoto UniversityInventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
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Publication number: 20110098185Abstract: This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.Type: ApplicationFiled: May 21, 2009Publication date: April 28, 2011Inventors: Akira Myomoto, Satoko Kozono, Hideo Akiyama, Hitoshi Nobumasa, Yutaka Shimada, Gozoh Tsujimoto
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Patent number: 7932032Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.Type: GrantFiled: May 2, 2006Date of Patent: April 26, 2011Assignees: Toray Industries, Inc., Kyoto UniversityInventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
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Patent number: 7910316Abstract: This invention relates to a method for detecting in vitro a urothelial cancer, comprising measuring CXCL1 protein, or expression of a gene encoding the protein, in a biological sample from a subject, and to a kit for diagnosing a urothelial cancer comprising an antibody or nucleic acid probe, which is capable of binding specifically to the CXCL1 protein or a gene encoding the protein, respectively.Type: GrantFiled: September 1, 2006Date of Patent: March 22, 2011Assignees: Toray Industries, Inc., Kyoto UniversityInventors: Hideo Akiyama, Yoshinori Tanaka, Satoko Kozono, Hitoshi Nobumasa, Osamu Ogawa, Takeshi Takahashi
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Publication number: 20100152055Abstract: This invention relates to a composition, kit, DNA chip, and use thereof for detecting, diagnosing, and predicting metastasis of kidney cancer and/or for predicting the prognosis for kidney cancer, comprising one or a plurality of polynucleotides selected from the group consisting of polynucleotides, mutants thereof or fragments thereof, the expression levels of which vary in kidney cancer cells from a patient with a poor prognosis when compared with that in kidney cancer cells from a patient with a good prognosis; or antibodies or fragments thereof that bind specifically to polypeptides, mutants thereof or fragments thereof, the expression levels of which vary in the similar manner.Type: ApplicationFiled: September 1, 2006Publication date: June 17, 2010Inventors: Satoko Kozono, Hideo Akiyama, Akira Myomoto, Yoshinori Tanaka, Giman Jung, Hitoshi Nobumasa, Osamu Nomura, Osamu Ogawa, Eijiro Nakamura, Gozo Tsujimoto
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Publication number: 20100009347Abstract: This invention relates to a method for detecting in vitro a urothelial cancer, comprising measuring CXCL1 protein, or expression of a gene encoding the protein, in a biological sample from a subject, and to a kit for diagnosing a urothelial cancer comprising an antibody or nucleic acid probe, which is capable of binding specifically to the CXCL1 protein or a gene encoding the protein, respectively.Type: ApplicationFiled: September 1, 2006Publication date: January 14, 2010Inventors: Hideo Akiyama, Yoshinori Tanaka, Satoko Kozono, Hitoshi Nobumasa, Osamu Ogawa, Takeshi Takahashi
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Publication number: 20090270267Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.Type: ApplicationFiled: May 2, 2006Publication date: October 29, 2009Applicants: TORAY INDUSTRIES, INC., Kyoto UniversityInventors: Hideo Akiyama, Satoko Kozono, Akira Myomoto, Osamu Nomura, Hitoshi Nobumasa, Yoshinori Tanaka, Shiori Tomoda, Yutaka Shimada, Gozoh Tsujimoto
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Publication number: 20070218453Abstract: This invention relates to a hollow-nanoparticle-based biosensing tool, which comprises proteins capable of forming nanoparticles through the incorporation of a lipid bilayer and specific biorecognition molecules bound thereto and a biosensing method using such tool.Type: ApplicationFiled: March 29, 2005Publication date: September 20, 2007Inventors: Katsuyuki Tanizawa, Shun'ichi Kuroda, Giman Jung, Hideo Akiyama, Hitoshi Nobumasa
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Patent number: 5977490Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 /g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique.The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.Type: GrantFiled: January 8, 1997Date of Patent: November 2, 1999Assignees: Matsushita Electric Industrial Co., Ltd., Dai-Ichi Kogyo Seiyaku Co. Ltd., Dowa Mining Co., Ltd.Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
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Patent number: 5914358Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 /g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.multidot.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.multidot.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique.The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.Type: GrantFiled: May 17, 1996Date of Patent: June 22, 1999Assignees: Matsushita Electric Industrial Co., Ltd., Dai-ichi Kogyo Seiyaku Co., Ltd., Dowa Mining Co., Ltd.Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
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Patent number: 5733467Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 / g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique. The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.Type: GrantFiled: March 10, 1997Date of Patent: March 31, 1998Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
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Patent number: 5652042Abstract: A conductive paste compound for via hole filling includes a conductive filler at 80 to 92 weight percent with an average particle size of from 0.5 to 20 .mu.m and specific surface of from 0.1 to 1.5 m.sup.2 /g, a liquid epoxy resin at 4.5 to 20 weight percent containing 2 or more epoxy groups with room temperature viscosity of 15 Pa.multidot.sec or less, and a hardener at 0.5 to 5 weight percent, wherein the viscosity is 2,000 Pa.multidot.sec or less and the volatile amount is 2.0 weight percent or less. A filling paste and a printed circuit board with use thereof are provided which can conduct an inner-via-hole connection between electrode layers without using a through-hole plating technique.The conductive paste comprises a metallic particle such as copper, an epoxy resin, a hardener, and if necessary, a dispersant. The paste having low viscosity and low volatility under high shear is used to fill holes disposed in a laminated substrate.Type: GrantFiled: October 28, 1994Date of Patent: July 29, 1997Assignees: Matsushita Electric Industrial Co., Ltd., Dai-Ichi Kogyo Seiyaku Co., Ltd., Dowa Mining Co., Ltd.Inventors: Kouji Kawakita, Seiichi Nakatani, Tatsuo Ogawa, Masatoshi Suehiro, Kouichi Iwaisako, Hideo Akiyama
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Patent number: 4686328Abstract: A hermetically sealed connector for a glove box and a method for exchanging such connectors in which leakage of radioactive material from within the glove box is minimized and an auxiliary glove box is not needed to exchange the connectors. The connector is formed as a cylindrical member having a flange portion hermetically sealed to a packing provided in a through hole in the wall of the glove box. To exchange connectors, a nut is removed from the outer end of the old connector and a tube is screwed thereto. The other end of the tube is fitted to the inner end of the new connector. The tube is then shoved through the packing until the flange of the new connector aligns with the packing. The tube is then removed from the inner end of the new connector and a nut is screwed on in replacement for the tube.Type: GrantFiled: April 20, 1984Date of Patent: August 11, 1987Assignees: Doryokuro Kakunenryo Kaihatsu Jigyodan, Hitachi Cable Ltd.Inventors: Masahito Ui, Hideo Akiyama, Akio Todokoro, Yukio Natsui, Hiroshi Kogure, Yujiro Kato, Tsuneo Ozaki